Introduction: To compare the effectiveness of Vacuum Assisted Closure (VAC) dressing over Conventional Dressing in case of Diabetic Foot Ulcers. In view of this, the present study was planned to weigh between Vacuum Assisted Closure (VAC) and the conventional dressing methods in case of Diabetic Foot Ulcer in factors like rate of granulation tissue formation, Bacterial clearance in the end of the therapy and duration of wound healing. Patients and Methods: This was a randomized comparative study conducted in the department of General Surgery, Indira Gandhi Institute of Medical Sciences, Patna from January 21 to December 22.50 patients with lower limb diabetic ulcers were included who were randomized into two groups-Conventional Dressing was done(n = 31); Vacuum Assisted Closure (VAC) dressing was done(n = 19). Patients were compared for outcomes after dressing. Statistical Analysis was done by SPSS software and P value < 0.05 were considered statistically significant. Result: Compared to Conventional Dressing,Vacuum Assisted Closure (VAC) Dressing group had comparable age,gender and associated comorbidities (p value > 0.05), took less but comparable duration for granulation tissue to appear (6.94SD2.61 vs. 9.03SD2.30, p value-0.29) took significantly lesser duration for wound culture to be negative (11.36SD4.47 vs. 14.83SD3.89, p value-0.037), took significantly lesser duration for wound healing (36.84SD9.34 vs. 43.16SD9.22, p value-0.033). Conclusion: Vacuum Assisted Closure (VAC) dressing was advantageous over Conventional Dressing for Dressing of lower limb diabetic ulcers in terms of time taken for formation of granulation tissue, time taken for wound culture to be negative and on long term follow ups, also in duration of healing of wounds.Vacuum Assisted Closure (VAC) dressing for chronic wounds or ulcers seemed to be a promising option to conventional dressing and the short-term results were good.