Outdoor activities in childhood: a protective factor for cutaneous melanoma? Results of a case-control study in 271 matched pairs

Kaskel, Peter; Sander, Silvia; Kron, Martina; Kind, Peter; Peter, R. U.; Krähn, Gertraud

doi:10.1046/j.1365-2133.2001.04432.x

Cited by 68 publications

(68 citation statements)

References 31 publications

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“…There was no association between lifetime UV exposure and melanoma risk among men who only mildly burn or tan. White et al [16] reported a protective effect for melanoma of high sun exposure during young ages among those who have a low sensitivity to the sun and Kaskal et al [31] reported a similar protective affect for outdoor activities during childhood. Additionally, Weinstock et al [32] showed a protective effect for melanoma among sunresistant women who had a high frequency of swimsuit use during their teen years.…”

Section: Discussionmentioning

confidence: 95%

Melanoma and lifetime UV radiation

Solomon

White

Kristal

et al. 2004

Cancer Causes Control

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Section: Discussionmentioning

confidence: 95%

Melanoma and lifetime UV radiation

Solomon

White

Kristal

et al. 2004

Cancer Causes Control

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“…In the United States alone studies show that the lifetime risk of developing malignant melanoma is 1 in 90 with a mortality rate of 1 in 400, and that the melanoma incidence rose 132% during the period 1979-1998 (Howe et al, 2001;Jemal et al, 2001). Statistics from a number of other countries have also demonstrated a rise in the incidence of melanoma (Armstrong and Kricker, 1994;Bennett and Hall, 1994;Parker et al, 1997;Bardeesy et al, 2000;Marks, 2000;Insinga et al, 2001;Kaskel et al, 2001).…”

Section: Clinical and Epidemiological Backgroundmentioning

confidence: 99%

Ultraviolet radiation and cutaneous malignant melanoma

2003

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Recent years have seen a steady rise in the incidence of cutaneous malignant melanoma worldwide. Although it is now appreciated that the key to understanding the process by which melanocytes are transformed into malignant melanoma lies in the interplay between genetic factors and the ultraviolet (UV) spectrum of sunlight, the nature of this relation has remained obscure. Recently, prospects for elucidating the molecular mechanisms underlying such gene-environment interactions have brightened considerably through the development of UV-responsive experimental animal models of melanoma. Genetically engineered mice and human skin xenografts constitute novel platforms upon which to build studies designed to elucidate the pathogenesis of UV-induced melanomagenesis. The future refinement of these in vivo models should provide a wealth of information on the cellular and genetic targets of UV, the pathways responsible for the repair of UV-induced DNA damage, and the molecular interactions between melanocytes and other skin cells in response to UV. It is anticipated that exploitation of these model systems will contribute significantly toward the development of effective approaches to the prevention and treatment of melanoma.

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“…4 In Germany, outdoor activities during childhood, in the absence of sunburn, were associated with a lower risk of melanoma. 25 Chronic, repeated sun exposure may allow the skin to accommodate to UV radiation by increasing melanin production, thereby reducing the risk of sunburn. 26 An English study published in 2011 showed that regular weekend sun exposure had a protective effect against CMM, and the researchers postulated that this may be mediated by photo-adaptation or higher vitamin D levels.…”

Section: How Sunscreen Can Contribute To Increased Melanoma Incidencementioning

confidence: 99%