Outdoor light at night, genetic predisposition and type 2 diabetes mellitus: A prospective cohort study

Xu, Zhihu; Jin, Jianbo; Yang, Teng; Wang, Yuxin; Huang, Jing; Pan, Xiaochuan; Frank, Kelly; Li, Guoxing

doi:10.1016/j.envres.2022.115157

Cited by 19 publications

(10 citation statements)

References 48 publications

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“…Our findings were consistent with these studies, 11,12 for outdoor LAN in every IQR increase, the HRs were 1.17 (95% CI, 1.06-1.29) for risk of CeVD in the singleexposure models and the associations persisted in the multiple-exposure models. For ischemic stroke, the association was attenuated to null after further adjusted for air pollution, which may be limited by statistical power, so large prospective studies are still needed to explore the association between outdoor LAN and stroke subtypes.…”

Section: Discussionsupporting

confidence: 92%

“…Growing evidence has indicated potential adverse effects of outdoor LAN. [10][11][12] In a cohort study based on UK Biobank, 12 every IQR increase in outdoor LAN was associated with a 5% elevated risk of type 2 diabetes and a cohort study from Hong Kong 11 suggested that per IQR increase for outdoor LAN was associated with 11% elevated risk of coronary heart disease hospitalizations.…”

Section: Discussionmentioning

confidence: 99%

“…Growing evidence has indicated potential adverse effects of outdoor LAN. 10–12 In a cohort study based on UK Biobank, 12 every IQR increase in outdoor LAN was associated with a 5% elevated risk of type 2 diabetes and a cohort study from Hong Kong 11 suggested that per IQR increase for outdoor LAN was associated with 11% elevated risk of coronary heart disease hospitalizations. Our findings were consistent with these studies, 11,12 for outdoor LAN in every IQR increase, the HRs were 1.17 (95% CI, 1.06–1.29) for risk of CeVD in the single-exposure models and the associations persisted in the multiple-exposure models.…”

Section: Discussionmentioning

confidence: 99%

“…10–12 In a cohort study based on UK Biobank, 12 every IQR increase in outdoor LAN was associated with a 5% elevated risk of type 2 diabetes and a cohort study from Hong Kong 11 suggested that per IQR increase for outdoor LAN was associated with 11% elevated risk of coronary heart disease hospitalizations. Our findings were consistent with these studies, 11,12 for outdoor LAN in every IQR increase, the HRs were 1.17 (95% CI, 1.06–1.29) for risk of CeVD in the single-exposure models and the associations persisted in the multiple-exposure models. For ischemic stroke, the association was attenuated to null after further adjusted for air pollution, which may be limited by statistical power, so large prospective studies are still needed to explore the association between outdoor LAN and stroke subtypes.…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence suggested that outdoor LAN may have adverse effects on health outcomes. [10][11][12] Despite the biological plausibility that circadian rhythm disturbances might cause CeVD, 13 little evidence can be available for the association between outdoor LAN and the risk of CeVD.…”

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confidence: 99%

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Outdoor Light at Night, Air Pollution, and Risk of Cerebrovascular Disease: A Cohort Study in China

Wu,

Shen,

Yang

et al. 2024

Stroke

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BACKGROUND: We sought to explore the associations of outdoor light at night (LAN) and air pollution with the risk of cerebrovascular disease (CeVD). METHODS: We included a total of 28 302 participants enrolled in Ningbo, China from 2015 to 2018. Outdoor LAN and air pollution were assessed by Satellite-derived images and land-use regression models. CeVD cases were confirmed by medical records and death certificates and further subdivided into ischemic and hemorrhagic stroke. Cox proportional hazard models were used to estimate hazard ratios and 95% CIs. RESULTS: A total of 1278 CeVD cases (including 777 ischemic and 133 hemorrhagic stroke cases) were identified during 127 877 person-years of follow-up. In the single-exposure models, the hazard ratios for CeVD were 1.17 (95% CI, 1.06–1.29) for outdoor LAN, 1.25 (1.12–1.39) for particulate matter with an aerodynamic diameter ≤2.5 µm, 1.14 (1.06–1.22) for particulate matter with aerodynamic diameter ≤10 μm, and 1.21 (1.06–1.38) for NO 2 in every interquartile range increase. The results were similar for ischemic stroke, whereas no association was observed for hemorrhagic stroke. In the multiple-exposure models, the associations of outdoor LAN and PM with CeVD persisted but not for ischemic stroke. Furthermore, no interaction was observed between outdoor LAN and air pollution. CONCLUSIONS: Levels of exposure to outdoor LAN and air pollution were positively associated with the risk of CeVD. Furthermore, the detrimental effects of outdoor LAN and air pollution might be mutually independent.

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Section: Discussionsupporting

confidence: 92%