2023
DOI: 10.1101/2023.09.16.557957
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Outer membrane proteins inMycobacterium tuberculosisand its potential role in small molecule permeation

Aseem Palande,
Saniya Patil,
Anjali Veeram
et al.

Abstract: Increased resistance to current anti-mycobacterial and a potential bias towards relatively hydrophobic chemical entities highlight an urgent need to understand how current anti-TB drugs enter the tubercle bacilli. While inner membrane proteins are well-studied, how small molecules cross the impenetrable outer membrane remains unknown. Here we employed mass spectrometry-based proteomics to show that octyl-β-glucopyranoside selectively extracts the outer membrane proteins ofMycobacterium tuberculosis. Differenti… Show more

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