Editorial on the Research TopicFundamentals and Applications of AI: An Interdisciplinary Perspective Machines, computers, and algorithms appear recurrently in the future imagined in science fiction pieces. Terminator's Skynet, Space Odyssey's HAL 9000, Psychohistory of Asimov's Foundation, and Westworld's Dolores are just a few examples of our collective imaginary of a (days) topic future. Interestingly, the year 2019 has represented the future in some works. Toronto Star in 1983 asked Asimov to predict the future, the world of 2019. This is also the case for Blade Runner, where the action runs in a dystopic LA, in 2019, with replicants having "almost" human cognitive capabilities. Although we have not reached most of the utopian pictures, the growth of Big Data and Artificial Intelligence algorithms is unquestionable (Figure 1). Thus, celebrating the unstoppable advance of AI, we collect in this RT several studies addressing fundaments and applications from a physics perspective.In 2020, AI has continued its penetration into classical fields and emerging technologies. Fueled by deep learning and the automatic generation of data, the techniques developed in AI are being applied to predict and control physical, biological, engineering, and even commercial systems. Given the two-way interaction between AI and different fields and including how these fields inspire novel methods and theory in AI, we had envisioned a volume illustrating such an interdisciplinary perspective. Contributions include quantum annealers and quantum neural networks, echo state networks, machine learning (reinforcement learning and graph-based methods), and applications to optimization, classification of heartbeats, animal collective movement, and climate forecast, and the use of AI to discover physical laws.A fast machine learning model for ECG-based heartbeat classification and arrhythmia detection was developed, based on echo state networks [1]. The classifier requires a small number of features and a single ECG signal suffices. The possibility of using a combination of ensembles allows them to exploit parallelism to train the classifier with remarkable speed. The sensitivity and predictive values are comparable with those of the state of the art in fully automatic ECG classifiers and even outperform other ECG classifiers that follow more complex feature selection approaches.Reservoir computers are investigated in two contributions. First, a coherent all-optical fiber-ring reservoir computer with distributed Kerr nonlinearity is investigated numerically and experimentally [2]. The system is based on a passive coherent optical fiber-ring cavity where part of the nonlinearity is due to the Kerr effect. They compare the nonlinear transformations of information in the reservoir's input layer, the reservoir itself, and the readout layer. They find that the Kerr effect enhances the computational capability of the reservoir, in particular, its nonlinear computational capacity. Second, the trade-off