Outpatient Renal Needle Biopsy of the Transplanted Kidney: Safety Profile

Petrone, H.; Frapiccini, M.G.; Skare, R.; Barán, Marcelo

doi:10.1016/j.transproceed.2011.09.086

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…After the removal of duplicates, 5004 unique records were identified, of which 4814 records were excluded after the screening of titles and abstracts. Of the 190 remaining studies, 72 studies (40 082 biopsies) 2,3,9,14,25-92 were included in the systematic review and meta-analysis after full-text review (Figure 1) including 4 single-center randomized controlled trials, 3 multicenter cohort studies (1 mixed retrospective-prospective and 2 retrospective), and 65 single-center cohort studies (10 prospective, 1 mixed retrospective-prospective, 46 retrospective, and 8 unreported). Details of the included studies are presented in Table S1, SDC, http://links.lww.com/TP/C332.…”

Section: Resultsmentioning

confidence: 99%

Complications of Percutaneous Kidney Allograft Biopsy: Systematic Review and Meta-analysis

Lim

Tan

et al. 2022

Transplantation

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Background. Kidney biopsy is important to guide the management of allograft dysfunction but has a risk of complications. This review aimed to determine the incidence and risk factors of complications after kidney allograft biopsy. Methods. This is a systematic review and meta-analysis of randomized controlled trials, cohort studies, or case-control studies indexed on PubMed, Embase, Cochrane Central Register of Controlled Trials, World Health Organization International Clinical Trials Registry, and ClinicalTrials.gov, limited to the English language, from January 2000 to December 2020, including adult and pediatric kidney allograft biopsies. Primary outcomes were gross hematuria, bleeding requiring transfusion, and major complications (requiring interventions such as blood transfusion or surgical or radiological interventions). Results. The review included 72 studies (40 082 biopsies). The quality of included studies was suboptimal. Pooled rates of gross hematuria, bleeding requiring transfusion, and major complications were 3.18% [95% confidence interval (95% CI), 2.31-4.19], 0.31% (95% CI, 0.15-0.52) and 0.89% (95% CI, 0.61-1.22), respectively. Gross hematuria rates were lower in high-income compared with middle-income countries (2.59% versus 6.44%, P < 0.01) and biopsies performed by radiology as compared with nephrology departments (1.25% versus 3.71%, P < 0.01). Blood transfusion rates were lower in pediatrics than adults (0.0% versus 0.65%, P < 0.01). Major complications were lower in biopsies performed by specialists as compared with trainees (0.02% versus 3.64%, P < 0.01). Graft loss and mortality were extremely rare. Limitations included missing data, few randomized controlled trials, and possible publication bias. Conclusions. The risk of complications after kidney allograft biopsy was low. Given the low quality of included studies, risk factors for complications should be further examined in future studies.

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Section: Resultsmentioning

confidence: 99%

Complications of Percutaneous Kidney Allograft Biopsy: Systematic Review and Meta-analysis

Lim

Tan

et al. 2022

Transplantation

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“…However, while gross hematuria is the most frequent problem, this does not compromise the patient or graft survival showing it to be a safe outpatient procedure [2]. Having demonstrated that this training model is easy to use providing haptic feedback as well as realistic ultrasound images, further studies are underway to determine its educational value.…”

Section: Discussionmentioning

confidence: 99%

“…There may be less time to learn allograft biopsies due to less frequent hemorrhagic complications than native kidney biopsies [2]. However, there is a reported 10% complication rate for outpatient needle biopsy of transplanted kidneys, resulting in re-hospitalization [3].…”

Section: Introductionmentioning

confidence: 99%

Cryo-preserved porcine kidneys are feasible for teaching and training renal biopsy: “the bento kidney”

et al. 2012

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BackgroundThe use of patients as the primary teaching modality for learning procedures is being questioned. While there have been advancements in the technology used for performing needle biopsies in both native and transplanted kidneys, there has been little advancement in teaching and training tools. We have developed a portable ex-vivo kidney, the Bento Kidney, using cryo-preserved porcine kidneys for teaching this procedure.MethodsThe kidney is thawed, perfused by a pump, covered with skin for realistic haptic feedback, and then used with existing biopsy technology to teach the technique.ResultsThirty porcine kidneys were used in this pilot research, and nine were shipped to physicians at a distant facility. Renal biopsy was then performed using a core biopsy needle and ultrasound guidance. There was some leakage of fluid from all kidneys noted. All trainees felt that the model was realistic, and judged at a mean score of 8.7 (SD 0.8) on a scale of 1 (not useful) to 10 (very useful).ConclusionsThis feasibility study demonstrates that cryo-preserved porcine kidneys can be successfully used to teach and train renal biopsy techniques, and provides haptic feedback as well as realistic real-time ultrasound images. Further large scale studies are needed to demonstrate value from the educational point of view for nephrology and transplantation.

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Outpatient Renal Needle Biopsy of the Transplanted Kidney: Safety Profile

Cited by 2 publications

References 6 publications

Complications of Percutaneous Kidney Allograft Biopsy: Systematic Review and Meta-analysis

Complications of Percutaneous Kidney Allograft Biopsy: Systematic Review and Meta-analysis

Cryo-preserved porcine kidneys are feasible for teaching and training renal biopsy: “the bento kidney”

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