Outpatient weekly 24‐hour infusional adjuvant chemotherapy of cisplatin, 5‐fluorouracil, and leucovorin for high‐risk nasopharyngeal carcinoma

Abstract

Outpatient weekly 24-hour continuous infusion PFL adjuvant chemotherapy is a well-tolerated regimen with promising results in high-risk NPC patients and merits investigation in phase III studies.

Long-term result of management of otitis media with effusion in patients with post-irradiated nasopharyngeal carcinoma

“…There were 24 females and 61 males. III and IV Neoadjuvant Cisplatin (60 mg/m 2 ) alternating with 5-Xuorouracil (2,500 mg/m 2 ) weekly for ten cycles [10] The mean age was 46.1 years with a range from 17 to 79 years. The mean RT dose over nasopharynx was 7,031.4 § 216.5 cGy.…”

“…The standard treatment protocol for NPC in our hospital has been built up and is summarized in Table 1 [9,10]. The diagnosis of OME was based on clinical symptoms of aural fullness, hearing impairment or tinnitus and otoscopic or microscopic Wndings.…”

Another way to estimate outcome of advanced nasopharyngeal carcinoma—is concurrent chemoradiotherapy adequate?

“…This strategy could be of benefit to high-risk patients. A nonrandomized study conducted by our group in which we administered 18 weekly doses of outpatient adjuvant chemotherapy consisting of cisplatin, 5-FU, and leucovorin showed significant reduction in distant failure rates and improvement in overall survival for high-risk patients (25). A Phase III randomized trial has also confirmed that adjuvant chemotherapy can significantly reduce distant metastasis rates for 1992 AJCC Stage IV patients (21).…”

Plasma epstein‐barr virus DNA concentration and clearance rate as novel prognostic factors for metastatic nasopharyngeal carcinoma

“…Nasopharyngeal carcinoma (NPC) is associated with Epstein‐Barr virus (EBV) infection. Although radiotherapy is the major therapy, studies have supported the use of combined chemotherapy and radiotherapy for patients with advanced disease 1–3. Although advances in radiation oncology including intensity‐modulated radiotherapy have improved the local control, distant metastasis becomes the main cause of treatment failure 1–4.…”