Depending on the trading modes, the effect of Outward Foreign Direct Investment (OFDI) on the manufacturing industry’s position within the global value chain (GVC) may differ considerably. This paper examines the GVC position of China’s manufacturing industry from 2003 to 2018, specifically focusing on the general trade and processing trade. Drawing upon this premise, this paper analyzes the effect and mechanism by which OFDI influences the GVC position of China’s manufacturing industry. The result demonstrates that: (1) China’s processing trade manufacturing industry has a much lower GVC position than general trade manufacturing industry. The GVC position of China’s general trade manufacturing industry rose from 2.76 to 2.90 from 2003 to 2018, while processing trade manufacturing industry remained around 1.93. (2) OFDI boosts the GVC position of general trade manufacturing industry through facilitating reverse technology spillover, inducing industry structure upgrading, and enabling export scale expansion. (3) OFDI hinders the GVC position growth of processing trade manufacturing industry. The research findings offer theoretical backing for China to develop OFDI strategies that are tailored to different trading modes within the new framework of dual circulation. These strategies aim to facilitate the transformation and advancement of the manufacturing industry, as well as the growth of the GVC position.