Outward Transport of Fluorescein From the Vitreous in Normal Human Subjects

Computer Modeling of Drug Delivery to the Posterior Eye: Effect of Active Transport and Loss to Choroidal Blood Flow

“…Active pumping of fluorescein from the vitreous to the blood was first observed by Cunha-Vaz and Maurice (13). Since then, a number of investigators (23)(24)(25)27) have calculated the resistance to the movement of fluorescein and FG from the vitreous to the blood and vice versa. These studies, however, did not differentiate between transport across the RPE layer and diffusion through the walls of the blood vessels.…”

“…The blood-vitreous barrier is comprised of the retinal pigment epithelium and the retinal and choroidal capillaries. The barrier has been shown to be asymmetric with respect to the transport of fluorescein (23)(24)(25)(26)(27). The outward permeability (vitreous to blood) of fluorescein is roughly 100 times higher than the inward permeability (28).…”

Ocular Fluorophotometric and Angiographic Findings in Toxemia of Pregnancy

“…For angiography and fluorophotometry, 14 mg/kg of 20% fluorescein sodium was injected intravenously, and angiography was performed immediately. One hour lat¬ er, the patient underwent topical anesthe¬ sia, and a corneal contact lens was fitted for fluorophotometry measurements.…”

Effect of Argon Laser Photocoagulation on the Permeability of the Blood-Retinal Barrier

“…The outward permeability coefficient (Pout) was calculated by using Blair's formula [5] on the assump tion that a rabbit eye had the hemispherical retina having a radius of 8 mm and a vitreous volume of about 1 ml [12], Vitreous fluorophotometry was also performed 7 and 14 days after photocoagulation.…”