Ovarian activity in dairy Saanen goats subjected to a short-term ovulation induction protocol and a single injection of lecirelin (GnRH analog) given 28 h or 34 h after progestin pre-treatment

Cosentino, Isabel Oliveira; Balaro, M. F. A.; Leal, Felipe Seabra Cardoso; Bade, Ana Luiza Cunha; Barbosa, Lucas de Figueiredo Cardoso; Gonçalves, Fernanda; Souza, Paula Renata Cortat de; Pereira, Pratibha; Bartlewski, Pawel M.; Brandão, Felipe Zandonadi

doi:10.1016/j.smallrumres.2020.106214

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…In ewes, when using 200UI of eCG at the sponge removal and GnRH 36h after sponge removal, females ovulated earlier on 56.2±3.8h after second sponge withdrawal (Cosentino et al, 2019). In goats, GnRH administration at 28 and 34h after the first sponge removal induced ovulation around 48 to 58h after sponge withdrawal (Cosentino et al, 2020a). For that matter, even if not tested in the present study, GnRH could also be administered in does 50h after removing the intravaginal device, to induce and reduce the ovulation window around 70h after MAP removal and enhance the protocol response allowing an FTAI with greater outcomes.…”

Section: Discussionmentioning

confidence: 98%

“…Ovarian US was conducted every 12h from sponge withdrawal (Day 21) until 108h after sponge withdrawal (Day 25) to evaluate follicular dynamics. Follicles were classified in small-sized (<3.0mm), mediumsized (3-6mm) and large-sized (>6.0mm), and were considered ovulated when the large-sized dominant follicle disappeared (Cosentino et al, 2020a;Castro et al, 1999;Ginther and Kot, 1994;Gonzalez de Bulnes et al, 1999). Another US scan was conducted at 240h (day 31) to assess ovulation by the presence of an active CL.…”

Section: Ultrasound Evaluation and Pregnancy Diagnosismentioning

confidence: 99%

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Influence of eCG and reproductive management in the resynchronization of ovulation in dairy goats

et al. 2022

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Resynchronization protocols have been proposed as a way of shortening females' unproductive time in the flock, with good results in cattle and sheep. In goats, initial studies have shown that a second progestogen device inserted before luteolysis and pregnancy diagnosis does not interfere with the corpus luteum lifespan or functionality. This study aimed to evaluate the follicular growth, ovulation pattern and pregnancy rate after insertion of a second and new progestogen device for resynchronizing, with or without equine Chorionic Gonadotrophin (eCG), submitted to natural mating (NM) or artificial insemination (AI) to propose a viable resynchronization protocol for dairy goats. A total of 38 multiparous Saanen goats underwent a short-term progesterone protocol [six days exposed to medroxyprogesterone acetate (MAP) intravaginal sponges + 200 IU eCG and 0.12 mg of cloprostenol sodium on the 5 th day + 0.025 mg of lecirelin 34 hours after sponge withdrawal] and, on day 16th after the ovulation, received a new MAP device which was retained until day 21. At this moment females were split into four groups: G eCG+NM -100 IU eCG with NM; G Sal+NM -saline solution with NM; G eCG+AI -100 IU eCG with AI; and G Sal+AI -saline solution with AI. Ultrasound scans were performed every 12 h from sponge withdrawal (day 21) until 108 h after sponge withdrawal (day 25) for follicular dynamics evaluation, at 240 h (day 31) for assessing the presence of active corpus luteum, and on day 60 for pregnancy diagnosis. No differences were found regarding ovulation time, synchronization and follicle size. However, G eCG+NM presented a greater estrus manifestation rate (100%) and pregnancy rate (62.5%) when compared to G Sal+AI . In conclusion, resynchronization protocols in dairy goats may present satisfactory results.

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Section: Discussionmentioning

confidence: 98%

Section: Ultrasound Evaluation and Pregnancy Diagnosismentioning

confidence: 99%

Influence of eCG and reproductive management in the resynchronization of ovulation in dairy goats

et al. 2022

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“…31 In other countries, 25 μg lecirelin is used for synchronizing ovulation in does. 32 The reported dosage for buserelin is even lower at 4 μg per doe. 33,34 In lactating dairy cows, both 450 μg (~ 0.7 μg/kg) and 750 μg (~ 1.2 μg/kg) deslorelin dosages have been investigated, with the larger dose causing a decrease in pregnancy rates, but both doses causing subsequent ovarian suppression.…”

Section: Discussionmentioning

confidence: 99%

Use of deslorelin acetate to advance ovulation in goats for timed artificial insemination

Stewart

Helms

Clark

et al. 2023

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The objective of this study was to determine the efficacy of deslorelin in advancing ovulation for timed artificial insemination (AI) protocols in goats. We hypothesized that deslorelin treatment advances the onset of ovulation and improves AI pregnancy rates. Does were synchronized using a 5-day CIDR (controlled internal drug releasing insert) protocol with prostaglandin treatment at CIDR insertion. For Experiment 1, does received 0.2 mg of intramuscular deslorelin (n = 9) or saline (control, n = 10) at CIDR removal. Serial blood collections and transrectal ultrasonography were performed to assess ovarian dynamics and identify ovulation. For Experiment 2, does received 0.2 mg of intramuscular deslorelin (n = 42), 5 ml of PMSG (pregnant mare serum gonadotropin)/hCG (human chorionic gonadotropin) (n = 42), or were left untreated (control, n = 42) at CIDR removal, and were subsequently bred by transcervical AI with fresh semen after 48 to 56 hours. Pregnancy diagnosis was performed at 50 and 90 days after AI. In Experiment 1, compared to control does, deslorelin-treated does had an increased (p < 0.01) number of ovulations and increased (p < 0.01) serum estradiol concentrations from 48 to 72 hours after CIDR removal. Serum progesterone concentrations did not differ between treatments. In Experiment 2, there was a main effect (p = 0.02) of treatment on pregnancy rates, with control does tending (p = 0.06) to have greater pregnancy rates than those treated with deslorelin or PMSG/hCG. Deslorelin treatment also resulted in decreased (p = 0.04) breeding season pregnancy rates and increased (p = 0.05) number of cycles to achieve pregnancy compared to control does. These results demonstrated that deslorelin not only has a super-ovulatory effect but also, at the dose given, can negatively impact does’ subsequent ovarian function and ability to achieve pregnancy.

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“…Intramuscular administration of PGF 2α or its analogues either in single dose or in two doses 10–11 days apart has been commonly used to synchronizing estrus during the breeding season (Duque‐Bonisoli et al, 2012; Mellado et al, 1994; Romano, 1998; Romano et al, 2017). Combination protocols of progestagens, PGF 2α , and equine chorionic gonadotropin or human chorionic gonadotropin have been increasingly used for improving synchronization rate of estrus and fertility after TAI (Abecia et al, 2012; Cosentino et al, 2020; Menchaca et al, 2007). However, these protocols involving multiple hormonal treatments require repeated tasks, such as holding and treating animals.…”

Section: Introductionmentioning

confidence: 99%

Effects of intravaginal administration of prostaglandin F_2α on luteolysis and subsequent estrus in Shiba goats (Capra hircus)

Akamatsu,

Tanaka,

Endo

2023

Animal Science Journal

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This study examined the effects of intravaginal administration of prostaglandin F2α (PGF2α) on luteolysis and subsequent estrus in cycling goats. Goats with functional corpus lutea received one of five treatments: 2 mg of PG intramuscularly (IM2 × 1; n = 6), 2 mg of PGF2α intravaginally (IVG2 × 1; n = 7), 4 mg of PGF2α intravaginally (IVG4 × 1; n = 7), and 1 or 2 mg of PGF2α intravaginally 8 h apart (IVG1 × 2 group; n = 6 and IVG2 × 2; n = 8). Blood samples were collected at 24‐h intervals from 0 to 7 days after PGF2α administration. Estrus was checked twice daily during the experiment. The proportion of goats with complete luteolysis (reduction of progesterone concentrations to <1 ng/mL until 48 h after treatment) in the IVG2 × 1 group (28.6%) was significantly lower than in the other groups (IM2 × 1; 100%, IVG4 × 1; 57.1%, IVG1 × 2; 87.5%, IVG2 × 2; 100%, respectively). For goats completing luteolysis, there was no significant difference in the onset and duration of estrus among the groups. These results suggest that intravaginal administration of PGF2α can be applied as an alternative to intramuscular administration.

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Ovarian activity in dairy Saanen goats subjected to a short-term ovulation induction protocol and a single injection of lecirelin (GnRH analog) given 28 h or 34 h after progestin pre-treatment

Cited by 4 publications

References 34 publications

Influence of eCG and reproductive management in the resynchronization of ovulation in dairy goats

Influence of eCG and reproductive management in the resynchronization of ovulation in dairy goats

Use of deslorelin acetate to advance ovulation in goats for timed artificial insemination

Effects of intravaginal administration of prostaglandin F_2α on luteolysis and subsequent estrus in Shiba goats (Capra hircus)

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Ovarian activity in dairy Saanen goats subjected to a short-term ovulation induction protocol and a single injection of lecirelin (GnRH analog) given 28 h or 34 h after progestin pre-treatment

Cited by 4 publications

References 34 publications

Influence of eCG and reproductive management in the resynchronization of ovulation in dairy goats

Influence of eCG and reproductive management in the resynchronization of ovulation in dairy goats

Use of deslorelin acetate to advance ovulation in goats for timed artificial insemination

Effects of intravaginal administration of prostaglandin F2α on luteolysis and subsequent estrus in Shiba goats (Capra hircus)

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Product

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Effects of intravaginal administration of prostaglandin F_2α on luteolysis and subsequent estrus in Shiba goats (Capra hircus)