Ovarian aging and bone metabolism in menstruating women aged 35–50 years

Vural, Fisun; Yücesoy, İzzet; Badur, Selim

doi:10.1016/j.maturitas.2005.01.009

Cited by 27 publications

(29 citation statements)

References 30 publications

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“…Our research has confirmed that serum FSH and LH levels in Chinese women are positively correlated with both bone formation indicators (BAP and OC) and bone resorption indicators (sNTX, sCTX, uNTX, uCTX, and uDPD), suggesting that the bone turnover speed becomes more rapid in women with increasing FSH and LH levels in circulation; this finding is similar to those of other studies [10,[27][28][29]. In contrast, however, Vural et al [15] found that serum FSH and LH levels are not correlated with the bone formation marker OC. Our results also demonstrate that bone turnover markers in quartile groups with high serum FSH and LH levels (Q3 and Q4) are higher than those in quartile groups with lower serum FSH and LH g sNTX=15.169+0.051×(LH), R 2 =0.018 (P=0.001).…”

Section: Discussionsupporting

confidence: 91%

“…However, from a physiopathological perspective, increased bone loss and bone resorption caused by early menopause and gonadal dysfunction should be attributed not just to a decrease in sex hormones because serum estrogen levels are not correlated with bone resorption indicators [4,39]. Increased premenopausal and perimenopausal bone resorption may also be due to increased secretion of gonadotropic hormone in circulation [34,35] and decreased secretion of inhibin B [15], as the levels of gonadotropic hormone are increased greatly and levels of estrogen are slightly decreased or BAP bone-specific alkaline phosphatase, OC osteocalcin, sNTX serum cross-linked N-terminal telopeptides of type I collagen (NTX), sCTX serum C-terminal telopeptides of type I collagen (CTX), uNTX urinary NTX, uCTX urinary CTX, uDPD urinary deoxypyridinoline a P=0.001 normal. In view of the relationship between serum FSH and LH and bone turnover indicators, measuring bone turnover indicators and FSH simultaneously is more effective in the screening and prediction of osteoporosis in perimenopausal women [40].…”

Section: Discussionmentioning

confidence: 99%

“…During menopause transition, women with higher levels of serum FSH experience more bone loss [13], and serum FSH levels were used to predict bone loss prior to estradiol and testosterone for this purpose [14]. Studies have also found that perimenopausal bone loss is related to increasing levels of FSH [15,16]. Further, serum FSH and LH can predict changes in BMD in men better than gonadal hormones [17].…”

Section: Introductionmentioning

confidence: 99%

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Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women

Xie

et al. 2009

Osteoporos Int

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women

Xie

et al. 2009

Osteoporos Int

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“…Subsequently, the confirmation of these actions in human cells provided further evidence that changes in ovarian inhibins might directly influence bone turnover via changes in cell differentiation [97]. Clinical studies in peri-menopausal women that measured serum circulating levels of steroids, inhibins and FSH confirmed that decrease in inhibin levels across the menopausal transition is associated with increasing bone turnover as well as with bone mass regardless of changes in steroids or FSH levels [95,97,98] (Fig. 4).…”

Section: Inhibins and Its Role In Tumourigenesismentioning

confidence: 83%

New targets for old hormones: inhibins clinical role revisited [Review]

2011

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Abstract. Inhibins are gonadal peptide hormones belonging to the transforming growth factor-β (TGF-β) superfamily that regulate the pituitary follicle stimulating hormone (FSH) secretion by negative feedback mechanisms. It is evident that the understanding of inhibins function in the hypothalamic-pituitary-gonadal axis will provide insights into physiology and pathology of the gonadal function. In recent years, a great deal of attention has been focussed on clinical relevance of measuring circulating inhibins in normal and disease state. The past few years also have witnessed the emergence and discovery of extra pituitary action of inhibins that might provide further insights into the underlying diseases like cancer especially in the reproductive axis and various other new endocrine target organs. In this review after systematic analysis of literature, we discuss briefly the known and recent advances in function of these hormones highlighting also its structure, production and mechanisms of signal transduction. Also this review discusses about the physiological relevance of inhibin association in the normal function to the development of reproductive cancers. Finally, we describe evidence from various emerging studies that inhibins make an important contribution to other physiological functions apart from reproduction which reveals new endocrine target organs of inhibins. The emerging view is inhibin participates in multiple ways to regulate the function in different cell types and still complete repertoire of its actions is under investigation. Key words: Inhibin, Transforming growth factor, Ovarian cancer, Activins, BetaglycanMAMMAliAn reproduction is intricate, highly ordered and is coordinated by assorted neural, neuroendocrine, endocrine, autocrine and paracrine cell-cell communication pathways. Many of the pioneering discoveries meticulously demonstrated the roles of hypothalamic gonadotropin releasing hormone (GnRH) that stimulates pituitary gonadotropins such as follicle stimulating hormone (FSH) and leutinizing hormone (LH), which directly control gonadal functions. Subsequent breakthroughs in the advancement of molecular biology and in understanding signal transduction mechanisms suggested involvement of various cytokines and growth factors at each level of the hypothalamic-pituitary-gonadal axis in the paracrine/autocrine control of different programmed reproductive events. Members include inhibins and activins, belonging to the transforming growth factor (TGF-β) super family and follistatin (FS), a structurally distinct though functionally related molecule. It has been more than 70 years since the identification of negative feedback control of pituitary FSH secretion by inhibins. These factors also were shown to act in autocrine, endocrine or paracrine manner within the reproductive tissues, but the identification of specific pathways in different cellular context along the gonadal axis is still quite unclear and should thus be further investigated. The discovery process of extra pituitary action of ...

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“…We have demonstrated direct suppressive effects of inhibins on osteoblasts and osteoclasts in mice and humans [21,22]. Clinical studies in women across the menopause transition demonstrate that decreases in inhibins are good predictors of increases in bone turnover markers in premenopausal, perimenopausal, and postmenopausal women, independent of both FSH and estradiol [22,26]. These findings also support the hypothesis that changes in inhibins drive the bone loss associated with onset of menopause, and suggest that like the pituitary, the skeleton is an inhibin target organ.…”

Section: Inhibins/activinsmentioning

confidence: 88%

Reproductive Hormones and Bone

Nicks

Fowler

Gaddy

2010

Curr Osteoporos Rep

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Hypothalamic gonadotropin-releasing hormone (GnRH) stimulates secretion of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which directly regulate ovarian function. Pituitary FSH can modulate osteoclast development, and thereby influence bone turnover. Pituitary oxytocin and prolactin effects on the skeleton are not merely limited to pregnancy and lactation; oxytocin stimulates osteoblastogenesis and bone formation, whereas prolactin exerts skeletal effects in an age-dependent manner. Cyclic levels of inhibins and estrogen suppress FSH and LH, respectively, and also suppress bone turnover via their suppressive effects on osteoblast and osteoclast differentiation. However, continuous exposure to inhibins or estrogen/androgens is anabolic for the skeleton in intact animals and protects against gonadectomy-induced bone loss. Alterations of one hormone in the hypothalamic-pituitary-gonadal (HPG) axis influence other bone-active hormones in the entire feedback loop in the axis. Thus, we propose that the action of the HPG axis should be extended to include its combined effects on the skeleton, thus creating the HPG skeletal (HPGS) axis.

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Ovarian aging and bone metabolism in menstruating women aged 35–50 years

Cited by 27 publications

References 30 publications

Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women

Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women

New targets for old hormones: inhibins clinical role revisited [Review]

Reproductive Hormones and Bone

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