Ovarian and peripheral androgen and oestrogen levels in post-menopausal women: correlations with ovarian histology

Lucisano, A.; Russo, Nicholas W.; Acampora, Marta; Fabiano, Alfredo; Fattibene, M.; Parlati, E.; Maniccia, E.; Dell'Acqua, S

doi:10.1016/0378-5122(86)90008-3

Cited by 32 publications

(18 citation statements)

References 17 publications

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“…androstenedione) if conversion to estrogen is rapid. This view is supported indirectly by several studies that have found that ovarian stromal hyperplasia is associated with elevated androgen concentrations in ovarian vein blood, but not with higher levels in peripheral venous blood [13,14,16]. Although some prior reports have found that higher BMI was associated with elevated testosterone levels [4,24], we found that the relationship between ovarian volume and androstenedione concentrations was unaffected by obesity status, as previously reported [25].…”

Section: Discussionsupporting

confidence: 65%

“…Similarly, Sluijmer et al [15] in a smaller investigation reported significant associations between ovarian stromal hyperplasia and venous androgen levels. Lucisano et al [16] also found significant associations between ovarian stromal hyperplasia and ovarian vein androgen levels, but not with endometrial carcinoma based on an analysis of 35 cancer patients and 23 patients with benign diseases. In contrast, in a study that compared ovarian morphology of 100 endometrial carcinoma patents to 100 cancer-free women, Marcus [17] reported that ovarian stromal hyperplasia was significantly related to endometrial carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Ovarian volumes among women with endometrial carcinoma: Associations with risk factors and serum hormones

Sherman¹,

Madigan²,

Lacey³

et al. 2007

Gynecologic Oncology

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Objectives-Data suggest that post-menopausal women with larger ovaries are at increased risk for endometrial carcinoma; however, analyses comparing ovarian volume to serum hormone levels are limited. Accordingly, we assessed ovarian volumes in relation to serum sex hormone levels among post-menopausal women with endometrial carcinoma who participated in a multi-center case control study.Methods-Data for established risk and protective factors for endometrial carcinoma were collected via in-person interviews. Ovarian volumes were estimated from pathology reports. Associations between exposures and age-adjusted ovarian volumes were analyzed for 175 cases with available data. For a subset of 135 cases, we analyzed relationships between ovarian volume, adjusted for age and body mass index (BMI), and serum hormone levels by analysis of variance.Results-Ovarian volume declined progressively from 1.83 cm 3 among women ages 55-59 years to 1.23 cm 3 among women age 70 years or older (p-trend = 0.02). Larger ovarian volume was associated with early menarche (p-trend = 0.03), having given birth (p = 0.01), and weakly with elevated BMI (p-trend = 0.06). After adjustment, increased ovarian volume, was associated with higher estradiol (p -trend = 0.007); albumin-bound estradiol (p -trend = 0.01); and free estradiol (p -trend = 0.006) levels; androstenedione, estrone and estrone sulfate showed similar, though nonsignificant associations.Conclusions-Among women with endometrial carcinoma, larger ovaries were associated with higher serum levels of estrogens. Further studies examining the role of the ovaries in post-menopausal hormonal carcinogenesis are warranted.

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Ovarian volumes among women with endometrial carcinoma: Associations with risk factors and serum hormones

Sherman¹,

Madigan²,

Lacey³

et al. 2007

Gynecologic Oncology

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“…Because of the unique anatomic proximity of the ovary and the uterus, and anastomozing ovarian and uterine vessels, testosterone secreted from the postmenopausal ovary may constitute a significant portion of the precursors of estradiol, which contribute to tumorigenesis of endometrial cancer (27). It has been noted that androgen secretion is increased from ovaries showing stromal hyperplasia (24,28,29), and women with endometrioid endometrial cancer show ovarian stromal hyperplasia more frequently than women without endometrial cancer (28,30).…”

Section: Discussionmentioning

confidence: 99%

Aromatase Expression in Stromal Cells of Endometrioid Endometrial Cancer Correlates with Poor Survival

Segawa

Shozu

Murakami

et al. 2005

Clinical Cancer Research

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“…Sci. USA 96 (1999)established that circulating estrogen levels are low after menopause but that the ovary continues to produce androgens and estrogens via aromatization (26,27). Hence, ovarian estrogens and/or androgens may be responsible for maintained normal HOSE cell functions after menopause.…”

Section: Fig 2 Sequence Analyses Of the Wild-type Er␣ Transcript (Ementioning

confidence: 99%

Expression of human estrogen receptor-α and -β, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells

Lau

Mok

1999

Proc. Natl. Acad. Sci. U.S.A.

256

161

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Our understanding of the roles played by sex hormones in ovarian carcinogenesis has been limited by a lack of data concerning the mode of sex hormone action in human ovarian surface epithelial (HOSE) cells, the tissue of origin of >90% of ovarian cancers. We have compared the relative abundance of estrogen receptor (ER)␣, ER␤, progesterone receptor (PR), and androgen receptor (AR) mRNA in four primary cultures of HOSE cells obtained from postmenopausal women to those found in late serous adenocarcinoma primary cell cultures and established ovarian cancer cell lines. We observed coexpression of ER␣ and ER␤ mRNA along with AR and PR transcripts in normal HOSE cells and disruption of ER␣ mRNA expression as well as dramatic down-regulation of PR and AR transcript expression in most ovarian cancer cells. In contrast, levels of ER␤ mRNA were unaffected by the malignant state. Additionally, a novel mutation involving a 32-bp deletion in exon 1 of ER␣ transcripts was detected in the SKOV3 cell line. This mutation would explain why SKOV3 was reported to be ER-positive but estrogen-insensitive. Taken together, these findings suggest that estrogens, signaling via either or both ER subtypes, may play an indispensable role in regulating normal HOSE cell functions. Therefore, loss of ER␣, PR, and AR mRNA expression in HOSE cells may be responsible for neoplastic transformation in this cell type. In contrast, the roles played by ER␤ in normal and malignant HOSE cells remain elusive. Finally, the coexistence of mutated ER␣ mRNA and normal ER␤ transcripts in SKOV3 argues in favor of a dependency of ER␤ action on functional ER␣s.

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Ovarian and peripheral androgen and oestrogen levels in post-menopausal women: correlations with ovarian histology

Cited by 32 publications

References 17 publications

Ovarian volumes among women with endometrial carcinoma: Associations with risk factors and serum hormones

Ovarian volumes among women with endometrial carcinoma: Associations with risk factors and serum hormones

Aromatase Expression in Stromal Cells of Endometrioid Endometrial Cancer Correlates with Poor Survival

Expression of human estrogen receptor-α and -β, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells

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