Ovarian and peripheral plasma levels of progestogens, androgens and oestrogens in post-menopausal women

Lucisano, A.; Acampora, Marta; Russo, Nicholas W.; Maniccia, E.; Montemurro, A.; Dell'Acqua, S

doi:10.1016/0378-5122(84)90064-1

Cited by 30 publications

(12 citation statements)

References 18 publications

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“…We have previously substantiated the hormonally active status of the postmenopausal ovary (25), confirming prior reports of other groups (26)(27)(28)(29)(30)(31)(32)(33). Using an improved method of blood collection for the ovarian venous effluent in addition to contemporary assay methods, statistically significant gradients between ovarian venous and peripheral concentrations of E 2 , E 1 , T, and A were demonstrated, confirming continued hormone production by the postmenopausal ovary.…”

supporting

confidence: 84%

“…Having previously demonstrated, along with others, that the postmenopausal ovary remains hormonally active (25)(26)(27)(28)(29)(30)(31)(32)(33), we hypothesized that oophorectomy would result in decreased circulating levels of steroid hormones, thereby modulating postoperative levels of IGF-1 and IGF-2, possibly leading to an altered risk of CRC in postmenopausal women.…”

mentioning

confidence: 98%

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Increased insulin-like growth factor-1 after oophorectomy in postmenopausal women

Fogle

Chang

Patel

et al. 2008

Fertility and Sterility

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supporting

confidence: 84%

mentioning

confidence: 98%

Increased insulin-like growth factor-1 after oophorectomy in postmenopausal women

Fogle

Chang

Patel

et al. 2008

Fertility and Sterility

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“…These investigators subsequently compared concentrations of T and A between the ovarian veins and peripheral circulation in postmenopausal women and were the first to observe concentration gradients of these androgens (2). Their findings were later supported by other reports (3)(4)(5)(6)(7)(8).…”

mentioning

confidence: 84%

Ovarian Androgen Production in Postmenopausal Women

Fogle

Stanczyk

Zhang

et al. 2007

The Journal of Clinical Endocrinology &Amp; Metabolism

250

108

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“…Sci. USA 96 (1999)established that circulating estrogen levels are low after menopause but that the ovary continues to produce androgens and estrogens via aromatization (26,27). Hence, ovarian estrogens and/or androgens may be responsible for maintained normal HOSE cell functions after menopause.…”

Section: Fig 2 Sequence Analyses Of the Wild-type Er␣ Transcript (Ementioning

confidence: 99%

Expression of human estrogen receptor-α and -β, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells

Lau

Mok

1999

Proc. Natl. Acad. Sci. U.S.A.

256

161

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Our understanding of the roles played by sex hormones in ovarian carcinogenesis has been limited by a lack of data concerning the mode of sex hormone action in human ovarian surface epithelial (HOSE) cells, the tissue of origin of >90% of ovarian cancers. We have compared the relative abundance of estrogen receptor (ER)␣, ER␤, progesterone receptor (PR), and androgen receptor (AR) mRNA in four primary cultures of HOSE cells obtained from postmenopausal women to those found in late serous adenocarcinoma primary cell cultures and established ovarian cancer cell lines. We observed coexpression of ER␣ and ER␤ mRNA along with AR and PR transcripts in normal HOSE cells and disruption of ER␣ mRNA expression as well as dramatic down-regulation of PR and AR transcript expression in most ovarian cancer cells. In contrast, levels of ER␤ mRNA were unaffected by the malignant state. Additionally, a novel mutation involving a 32-bp deletion in exon 1 of ER␣ transcripts was detected in the SKOV3 cell line. This mutation would explain why SKOV3 was reported to be ER-positive but estrogen-insensitive. Taken together, these findings suggest that estrogens, signaling via either or both ER subtypes, may play an indispensable role in regulating normal HOSE cell functions. Therefore, loss of ER␣, PR, and AR mRNA expression in HOSE cells may be responsible for neoplastic transformation in this cell type. In contrast, the roles played by ER␤ in normal and malignant HOSE cells remain elusive. Finally, the coexistence of mutated ER␣ mRNA and normal ER␤ transcripts in SKOV3 argues in favor of a dependency of ER␤ action on functional ER␣s.

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Ovarian and peripheral plasma levels of progestogens, androgens and oestrogens in post-menopausal women

Cited by 30 publications

References 18 publications

Increased insulin-like growth factor-1 after oophorectomy in postmenopausal women

Increased insulin-like growth factor-1 after oophorectomy in postmenopausal women

Ovarian Androgen Production in Postmenopausal Women

Expression of human estrogen receptor-α and -β, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells

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