Ovarian Cancer and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study

Guo, Jian-Zeng; Xiao, Qiang; Wu, Lang; Chen, Fa; Yin, Jia-Li; Qin, Xue; Gong, Ting-Ting; Wu, Qi‐Jun

doi:10.3390/jcm12082961

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…This study employed two-sample MR analysis to investigate the causal impact of obesity on anal stula. And the results of MR analysis are relatively immune to above confounding factors because of the random assignment of alleles during meiosis 18,23 . Furthermore, this study is the rst to investigate the potential causal associations between obesity and stula anal using MR methods.…”

Section: Discussionmentioning

confidence: 99%

Associations of Obesity with the Risk of Anal Fistula: A Mendelian Randomization Study

Zhao,

Song,

Zhang

2024

Preprint

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(1) Background: Obesity has become a worldwide pandemic, while anal fistulas represent a prevalent anorectal disorder that affects a significant number of individuals across the globe. However, the relationship between obesity and anal fistula remains unclear. (2) Methods: We assess obesity comprehensively through multiple indicators including body mass index (BMI), body fat percentage (BFP), waist circumference (WC), and waist-hip ratio (WHR). In order to evaluate the causal effects of obesity on the risk of anal fistula, two-sample Mendelian randomization (MR) analysis was completed using five methods: inverse variance weighting (IVW), MR-Egger, weighted median, simple mode and weighted mode. IVW method was used as the main method. (3) Results: IVW method found that there were positive effects of genetically determined BMI (OR: 1.001, 95%CI: 1.001-1.002, p = 0.022), BFP (OR: 1.001, 95%: 1.000-1.003, p = 0.035), WC (OR: 1.001, 95%CI: 1.000-1.003, p = 0.035), WHR (OR: 1.001, 95%CI: 1.000-1.003, p = 0.024) on the risk of anal fistula. The MR-Egger intercepts and MR-PRESSO method show no evidence for significant pleiotropy and heterogeneity. (4) Conclusion: Our MR study supports a causal role of obesity in increasing the risk of anal fistula. We emphasize that obese patients with anal fistula underscore the urgent need for attention to weight control.

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Section: Discussionmentioning

confidence: 99%

Associations of Obesity with the Risk of Anal Fistula: A Mendelian Randomization Study

Zhao,

Song,

Zhang

2024

Preprint

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Causal association between Parkinson’s disease and cancer: a bidirectional Mendelian randomization study

Tang,

Fu,

Lin

et al. 2024

Front. Aging Neurosci.

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BackgroundPrevious observational research has indicated a correlation between Parkinson’s disease (PD) and multiple cancers; but the causality remains unclear. Thus, we utilized Mendelian randomization (MR) analysis to explore the potential causal link between PD and various cancers.MethodsWe conducted a bidirectional two-sample Mendelian randomization (TSMR) of genetic variants associated with PD and 14 types of cancers. Summary statistics on PD and 14 types of cancers were obtained from the International Parkinson’s Disease Genomics Consortium and the study by Sakaue et al. The primary method employed was inverse variance weighted (IVW), complemented by multiple sensitivity analyses to evaluate heterogeneity and pleiotropy. The false discovery rate (FDR) was employed to control the false positive rate of multiple hypothesis testing.ResultsFollowing rigorous sensitivity analyses and corrections, our findings revealed suggestive associations between PD and certain cancers. We observed that PD decreases the risk of gastric cancer and colorectal cancer (OR = 0.936, 95% CI = 0.881–0.995, p = 0.034, P FDR = 0.239; OR = 0.955, 95% CI = 0.912–0.999, p = 0.046, P FDR = 0.215), while increasing the risk of breast cancer (OR = 1.043, 95% CI = 1.004–1.084, p = 0.029, P FDR = 0.402). Notably, we found no evidence supporting a reverse causal relationship. Additionally, in the reverse pathway, skin cancer demonstrated a suggestive causal relationship with PD (OR = 0.913, 95% CI = 0.857–0.973, p = 0.005, P FDR = 0.066).ConclusionOur MR analysis provides evidence supporting unidirectional suggestive causal relationships between PD and certain cancers. These findings enrich our comprehension of the intricate interplay between PD and cancer, warranting further investigation into the underlying biological mechanisms.

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Ovarian Cancer and Parkinson’s Disease: A Bidirectional Mendelian Randomization Study

Cited by 2 publications

References 51 publications

Associations of Obesity with the Risk of Anal Fistula: A Mendelian Randomization Study

Associations of Obesity with the Risk of Anal Fistula: A Mendelian Randomization Study

Causal association between Parkinson’s disease and cancer: a bidirectional Mendelian randomization study

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