Ovarian cancer presenting with hypercalcemia: two cases with similar manifestations but different mechanisms

Ma, Xuegong; Wang, Yingmei; Zhang, Xuhong; Dong, Mengting; Yang, Wen; Xue, Fengxia

doi:10.20892/j.issn.2095-3941.2018.0009

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…The mechanisms of MAHC include HHM (humoral hypercalcemia in malignancy), primary or secondary hyperparathyroidism, osteolytic hypercalcemia, and vitamin D secreting lymphomas [4]. HHM, which is related to malignant tumor cell secretion of PTH-rP, is the most common cause of MAHC [2].…”

Section: Discussionmentioning

confidence: 99%

“…MAHC can be classified into four types; humoral hypercalcemia of malignancy (HHM), primary or ectopic hyperparathyroidism, osteolytic hypercalcemia, and vitamin D secreting lymphomas [4]. Since the etiology of hypercalcemia is different for each of the four types, the correct differential diagnosis of hypercalcemia is essential to ensure correct treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hypercalcemia associated with primary mucinous ovarian tumor followed by pseudomyxoma peritonei can be fatal: a case report

Yeom¹,

Lee²,

Kim³

2020

European Journal of Gynaecological Oncology

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Hypercalcemia is a common complication of malignancy, occurring in up to 30% of patients. The development of hypercalcemia in patients with cancer portends a worse prognosis, with patients more likely to have advanced disease and decreased survival rates. Mucinous neoplasms of the ovary account for 10%-15% of ovarian neoplasms. They may be benign, borderline, or malignant. The majority are benign or borderline, accounting for 80% and 16%-17%, respectively. Pseudomyxoma peritonei (PMP) is a rare disease. It refers that PMP is the accumulation of mucin in the abdominal or pelvic cavity derived from associated mucinous tumor usually from the appendix, but also associated with ovarian mucinous tumors. Herein, we report a case of hypercalcemia associated with primary mucinous ovarian tumor followed by PMP that had fatal consequences.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypercalcemia associated with primary mucinous ovarian tumor followed by pseudomyxoma peritonei can be fatal: a case report

Yeom¹,

Lee²,

Kim³

2020

European Journal of Gynaecological Oncology

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“…A quick Google search identifies several case reports describing hypercalcemia associated with parathyroid hormone in women with ovarian cancer, including a high-profile study by Nussbaum and colleagues [17] and a more recent one by Ma and colleagues [18]. These findings provide validation of TranQL and further suggest avenues for exploratory drug discovery in the treatment of ovarian cancer.…”

Section: Use Casementioning

confidence: 94%

Visualization Environment for Federated Knowledge Graphs: Development of an Interactive Biomedical Query Language and Web Application Interface

et al. 2020

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Background Efforts are underway to semantically integrate large biomedical knowledge graphs using common upper-level ontologies to federate graph-oriented application programming interfaces (APIs) to the data. However, federation poses several challenges, including query routing to appropriate knowledge sources, generation and evaluation of answer subsets, semantic merger of those answer subsets, and visualization and exploration of results. Objective We aimed to develop an interactive environment for query, visualization, and deep exploration of federated knowledge graphs. Methods We developed a biomedical query language and web application interphase—termed as Translator Query Language (TranQL)—to query semantically federated knowledge graphs and explore query results. TranQL uses the Biolink data model as an upper-level biomedical ontology and an API standard that has been adopted by the Biomedical Data Translator Consortium to specify a protocol for expressing a query as a graph of Biolink data elements compiled from statements in the TranQL query language. Queries are mapped to federated knowledge sources, and answers are merged into a knowledge graph, with mappings between the knowledge graph and specific elements of the query. The TranQL interactive web application includes a user interface to support user exploration of the federated knowledge graph. Results We developed 2 real-world use cases to validate TranQL and address biomedical questions of relevance to translational science. The use cases posed questions that traversed 2 federated Translator API endpoints: Integrated Clinical and Environmental Exposures Service (ICEES) and Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP). ICEES provides open access to observational clinical and environmental data, and ROBOKOP provides access to linked biomedical entities, such as “gene,” “chemical substance,” and “disease,” that are derived largely from curated public data sources. We successfully posed queries to TranQL that traversed these endpoints and retrieved answers that we visualized and evaluated. Conclusions TranQL can be used to ask questions of relevance to translational science, rapidly obtain answers that require assertions from a federation of knowledge sources, and provide valuable insights for translational research and clinical practice.

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Visualization Environment for Federated Knowledge Graphs: Development of an Interactive Biomedical Query Language and Web Application Interface (Preprint)

Cox¹,

Ahalt²,

Balhoff³

et al. 2020

Preprint

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BACKGROUND Efforts are underway to semantically integrate large biomedical knowledge graphs using common upper-level ontologies to federate graph-oriented application programming interfaces (APIs) to the data. However, federation poses several challenges, including query routing to appropriate knowledge sources, generation and evaluation of answer subsets, semantic merger of those answer subsets, and visualization and exploration of results. OBJECTIVE We aimed to develop an interactive environment for query, visualization, and deep exploration of federated knowledge graphs. METHODS We developed TranQL (Translator Query Language) as a biomedical query language and web application interface to query semantically federated knowledge graphs and explore query results. TranQL uses the Biolink data model as an upper-level biomedical ontology and an API standard that has been adopted by the Biomedical Data Translator Consortium to specify a protocol for expressing a query as a graph of Biolink data elements compiled from statements in the TranQL query language. Queries are mapped to federated knowledge sources, and answers are merged into a knowledge graph, with mappings between the knowledge graph and specific elements of the query. The TranQL interactive web application includes a user interface (UI) to support user exploration of the federated knowledge graph. RESULTS We developed two real-world use cases to validate TranQL and address biomedical questions of relevance to translational science. The use cases posed questions that traversed two federated Translator API endpoints: ICEES (Integrated Clinical and Environmental Exposures Service), which provides open access to observational clinical and environmental data; and ROBOKOP (Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways), which provides access to linked biomedical entities such as ‘gene’, ‘chemical substance’, and ‘disease’ that are derived largely from curated public data sources. We successfully posed queries to TranQL that traversed these endpoints and retrieved answers that we then visualized and evaluated. CONCLUSIONS TranQL can be used to ask questions of relevance to translational science, rapidly obtain answers that require assertions from a federation of knowledge sources, and provide valuable insights for translational research and clinical practice. CLINICALTRIAL

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Ovarian cancer presenting with hypercalcemia: two cases with similar manifestations but different mechanisms

Cited by 3 publications

References 20 publications

Hypercalcemia associated with primary mucinous ovarian tumor followed by pseudomyxoma peritonei can be fatal: a case report

Hypercalcemia associated with primary mucinous ovarian tumor followed by pseudomyxoma peritonei can be fatal: a case report

Visualization Environment for Federated Knowledge Graphs: Development of an Interactive Biomedical Query Language and Web Application Interface

Visualization Environment for Federated Knowledge Graphs: Development of an Interactive Biomedical Query Language and Web Application Interface (Preprint)

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