Ovarian cancer risk and nonisoflavone flavonoids intake: A systematic review of epidemiological studies

Abstract

Background:Although several studies have investigated the association between ovarian cancer risk and nonisoflavone flavonoids intake, these findings are inconsistent. This systematic review of published epidemiological studies was conducted to summarize and clarify the evidence on the association between ovarian cancer incidence and nonisoflavone flavonoids intake.Materials and Methods:PubMed, Scopus, Google Scholar, and EMBASE databases were searched based on MeSH term (ovarian neoplasm in combination with flavonoids) to identify related English and non-English papers published up to June 2016. We summarized the results of the relevant studies in this review.Results:In total, seven studies (four with cohort and three with case–control design) included in this review. The results of conducted cohort studies show no relation between ovarian cancer risk and total nonisoflavone flavonoids intake, and only one study reported a significant reduction between ovarian cancer incidence and kaempferol and luteolin intake. Similar to those in the cohort studies, also in case–control studies, no association was found between total nonisoflavone flavonoids intake and ovarian cancer risk, just an inverse association between flavonols intake and ovarian cancer was reported.Conclusion:Several studies investigated the relation of nonisoflavone flavonoids intake and ovarian cancer risk; none of them reported any association for total nonisoflavone flavonoids intake, but some reported an inverse association between certain subclasses or individual flavonoids. These findings are limited, and there is a need for further and more accurate researches to be confirmed.

Could ALDH2*2 be the reason for low incidence and mortality of ovarian cancer for East Asia women?

“…Ovarian cancer is the seventh most common cancer in women and is the eighth most frequent cause of cancer death among women [ 1 ]. The occurrence of ovarian cancer has been related to many factors, for example, age of menarche [ 2 , 3 ], short or irregular cycles [ 2 – 6 ], age of menopause [ 7 , 8 ], age of the first birth [ 2 , 3 , 9 , 10 ], age of last pregnancy [ 7 , 10 , 11 ], the number of children [ 2 , 3 , 7 , 10 , 11 ], period of breastfeeding [ 12 – 16 ], oral contraceptives [ 17 – 21 ], intake of phytochemicals [ 22 ], genes BRCA1 or BRCA2 [ 23 ], etc.…”

Luteolin Suppresses Teratoma Cell Growth and Induces Cell Apoptosis via Inhibiting Bcl-2

“…They also possess broad therapeutic effects such as antiviral, hypoglycemic, anti-inflammatory, and neurological protection. Luteolin, which belongs to the flavonoids, can be extracted from many natural plants such as greens, fruit crops, and medicinal herbs 10 . Luteolin possesses a variety of pharmacological activities as do other flavonoids, including antioxidants, antineoplastic, antiphlogistic, heart protection, and immunomodulatory effects 11,12 .…”

Evaluation of ovarian function after hysterectomy with or without salpingectomy: A feasible study

“…[ 8 ] Other factors for malignancy risk reduction are: OCP consumption, use of flavonoids which exists in leafy vegetables and apple and also quercetin therapy as another flavonoid, hysterectomy, bilateral salpingo-oophorectomy, tube ligation, multiparity, and breastfeeding. [ 2 9 10 ]…”