Ovarian Cancer Surgery – A Population-based Registry Study

Leandersson, Pia; Granåsen, Gabriel; Borgfeldt, Christer

doi:10.21873/anticanres.11519

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…Querleu et al studied 1,000 gynecologic cancer patients who underwent laparoscopic pelvic and/or para-aortic lymphadenectomies [ 21 ]. The intra-operative and early post-operative complication rates, as well as the lymphocyst formation rate were 2.0% and 2.9%, respectively [ 20 ]. Although laparoscopic lymphadenectomy is considered safe, laparoscopic equipment is available in only some tertiary hospitals due to a lack of financial support; hence, 89% of this population underwent exploratory laparotomy.…”

Section: Discussionmentioning

confidence: 99%

“…Franchi et al reported a post-operative complica- tion rate of 33.8% (45/133) in endometrial cancer patients [17]. The post-operative complication rate of ovarian cancer patients, depending on the extension of surgical procedures, ranged from 13.3% to 29.9% [18][19][20]. In our subgroups analysis, the overall complication rates in cervical cancer, endometrial cancer and ovarian cancer patients were 39.5%, 29.9% and 59.3%, respectively.…”

Section: Discussionmentioning

confidence: 99%

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A Retrospective Study of Complications Following Pelvic and Para-Aortic Lymphadenectomy in Gynecologic Oncology

Saemathong,

Chaowawanit

2024

World J Oncol

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Background Lymphadenectomy plays an essential role in the staging protocols for gynecologic cancers, as recommended by International Federation of Gynecology and Obstetrics (FIGO). While its benefits vary, complications may arise during intra-operative, acute post-operative, or long-term periods. Notably, lymphadenectomy-associated systemic morbidity and specific complications such as lymphocele and lymphedema have been reported. Methods This retrospective study involved 399 patients with cervical, endometrial, and ovarian cancers who underwent pelvic and para-aortic lymphadenectomy. The follow-up period was at least 3 months. Intra-operative complications encompassed adjacent organ injury and significant blood loss, while acute post-operative complications occurred within 29 days. Post-30-day complications included lymphocele and lymphedema. Logistic regression analysis identified predictors for complications. Results The overall complication rate was 42.4%, with intra-operative, acute post-operative, and long-term rates of 26.1%, 11.0%, and 14.0%, respectively. Predictors for overall complications included laparotomy, positive lymph nodes, and operative time > 240 min. For intra-operative complications, age > 60 years, laparotomy, positive lymph nodes, and operative time > 240 min were significant predictors. Symptomatic lymphocele and lymphedema occurred in 6.0% and 2.0% of patients, respectively, mainly in the long-term period. Conclusion Although the overall complication rate after gynecologic surgery was found to be almost half of all cases, the rate of severe complications was low. Additionally, the rates of symptomatic lymphocele and lymphedema were low. Lymphadenectomy in gynecologic cancer surgery can be performed safely.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Retrospective Study of Complications Following Pelvic and Para-Aortic Lymphadenectomy in Gynecologic Oncology

Saemathong,

Chaowawanit

2024

World J Oncol

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“…In this study, hospital-registry data enabled a greater depth of analysis and greater clinical insights than was possible with population-based registry data that generally exclude data on stage, other prognostic and treatment characteristics. Ideally, hospital-registry data would be extended to cover the entire population, as in Sweden 26. Increased interest exists in recording cancer stage in population-based registries and linking these data to inpatient and health insurance treatment data in Australia 27.…”

Section: Discussionmentioning

confidence: 99%

Exploring the added value of hospital-registry data for showing local service outcomes: cancers of the ovary, fallopian tube and peritoneum

et al. 2019

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ObjectivesTo explore the added value of hospital-registry data on invasive epithelial ovarian, tubal and peritoneal cancers.DesignHistoric cohort analyses.MethodsUnadjusted and adjusted regression.SettingMajor South Australian hospitals.Participants1596 women (1984–2015 diagnoses).Results5-Year and 10-year survival was 48% and 41%, respectively, equivalent to relative survival for Australia and the USA. After adjusting for age, clinical and geographic factors, risk of ovarian cancer death was 25% lower in 2010–2015 than 1984–1989. Women generally had surgical treatment (87%) in their first round of care. This was more common for younger patients (adjusted OR (95% CIs) 0.17 (0.04 to 0.65) for 80+ vs <40 years) and earlier International Federation of Gynecology and Obstetrics stages (adjusted OR 0.48 (0.13 to 1.78) for stage IIIB/C and 0.13 (0.04 to 0.45) for stage IV vs stage IA). Most (74%) had systemic therapy, which was more common for advanced stages (adjusted ORs >15.0 for stages III and IV vs stage IA). Few (9%) had radiotherapy. Women generally had systemic therapy (74%), without difference by service accessibility and socioeconomic disadvantage, suggesting equity. However, surgery was less common for residents of the most compared with least remote areas (adjusted OR 0.49 (0.24 to 0.99)); and more common prior to adjustment in the highest versus lowest socioeconomic category (unadjusted OR 1.55 (1.01 to 2.39)), but this elevation did not apply after adjustment (adjusted OR 0.19 (0.63 to 2.25)), with the difference largely explained by stage.ConclusionsHospital-registry data add value for assessing local service delivery. Equivalent survival to Australia-wide and USA survival, and temporal gains after adjusting for stage and other patient characteristics are reassuring. Survival gains may reflect therapeutic benefits of more extensive surgery and improved chemotherapy regimens.

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Complications and Survivorship Trends After Primary Debulking Surgery for Ovarian Cancer

Becerra

Justiniano

et al. 2020

Journal of Surgical Research

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Background:We examined factors associated with postoperative complications, 1-year overall and cancer-specific survival after epithelial ovarian cancer (EOC) diagnosis.Methods: Patients who underwent surgery for EOC between 2004 and 2013 were included. Multivariable models analyzed postoperative complications, overall survival, and cancer-specific survival.Results: Among 5223 patients, surgical complications were common. Postoperative complications correlated with increased odds of overall and disease-specific survival at 1 y. Receipt of chemotherapy was similar among women with and without postoperative complications

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Ovarian Cancer Surgery – A Population-based Registry Study

Abstract: Abstract. Background

Cited by 8 publications

References 20 publications

A Retrospective Study of Complications Following Pelvic and Para-Aortic Lymphadenectomy in Gynecologic Oncology

A Retrospective Study of Complications Following Pelvic and Para-Aortic Lymphadenectomy in Gynecologic Oncology

Exploring the added value of hospital-registry data for showing local service outcomes: cancers of the ovary, fallopian tube and peritoneum

Complications and Survivorship Trends After Primary Debulking Surgery for Ovarian Cancer

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