Ovarian Cancer Tumour Biology: Genesis

Abstract

Ovarian cancer (OC) is the fifth leading cause of cancer deaths among women, thus early diagnosis is of paramount importance to survival. A clear OC etiopathogenesis is not yet fully understood. Large histopathological variability predicts more initial tissue for carcinogenesis. Many connections of biologically different tissue as locus minoris resistentiae for carcinogenesis have been confirmed. Expansion of knowledge about OC etiopathogenesis may help to construct an algorithm for early diagnosis. Ovarian surface epithelium, ectopic Müllerian epithelium, and fallopian tubes, along with endometriosis, are significant in the process of OC development. An oxidative microenvironment caused by recurrent ovulation or arising due to a degradative process in ectopic endometrium, mainly endometriomas, play a prominent role in the development of OC.

Deciphering resistance mechanisms and novel strategies to overcome drug resistance in ovarian cancer: a comprehensive review

“…The results showed that the selectivity indices of carboplatin and plasma-activated medium (PAM) for A2780 CP and SKOV-3 were significantly higher than those of traditional chemotherapeutic drugs. Particularly, PAM with 10% FBS exhibited the highest selectivity towards OC cells among all plasma treatment methods, surpassing the selectivity of various plasma therapies and conventional chemotherapeutic drugs [ 163 ].…”