Ovarian Carcinoma in Patients with Endometriosis

Tanaka, Yumiko; Yoshizako, Takeshi; Nishida, Masato; Yamaguchi, Masayuki; Sugimura, Kazuro; Itai, Yuji

doi:10.2214/ajr.175.5.1751423

Cited by 145 publications

(72 citation statements)

References 17 publications

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“…The incidence of malignant transformation in endometriomas reaches 0.6-1.0%, and endometrioid carcinoma is the most commonly reported histological type, followed by clear cell carcinoma [9][10][11]. We report two cases of malignant transformation within an endometrioid cyst, 1 endometrioid carcinoma and 1 mucinous borderline tumor both presenting with shading sign.…”

Section: Discussionmentioning

confidence: 86%

The shading sign: is it exclusive of endometriomas?

et al. 2015

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Section: Discussionmentioning

confidence: 86%

The shading sign: is it exclusive of endometriomas?

et al. 2015

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“…Among the 179 lesions, 153 benign and 26 malignant lesions were diagnosed based on the preoperative MRI (as mentioned above, our MR criteria for malignant transformation with endometriomas were enhanced mural nodules in the dynamic study [9] The MRI appearances of the ovarian lesions in each patient group are summarized in Table 2. On MRI, the mean diameter of all the lesions was 57.8 mm (13 -150 mm), the mean thickness of the cyst wall was 3.0 mm (2 -5 mm), and the mean thickness of the septum was 3.0 mm (1 -5 mm).…”

Section: Resultsmentioning

confidence: 99%

“…Our MR criteria for endometriomas were hyperintense lesions on T1-weighted images and fat-saturated T1-weighted images [3] [5] [8]. Our MR criteria for malignant transformation with endometriomas were enhanced mural nodules in the dynamic study [9]. We categorized the cystic ovarian lesions into benign and malignant groups based on the MRI criteria described above.…”

Section: Mri Techniquementioning

confidence: 99%

“…Tanaka YO, et al [7] reported that 7 of 16 (44%) cases without malignancy showed mural nodules with contrast enhancement; only one case had a granulomatous tissue within ectopic endometriotic tissue, and the others were composed of only endometriosis. However, blood clots in endometriomas can be interpreted as mural nodules, and may be suspected to be a "mural nodule" within the endometrioma on MR images [9] [17] [18]. Recently, Corwin MT, et al reported that dark spot sign on T2-weighted image is useful to differentiate endometriomas from hemorrhagic cysts.…”

Section: Enhancementmentioning

confidence: 99%

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MR Differentiation of Endometriomas Complicated with and without Malignancy: Comparison with Pathological Findings

Kohno¹,

Tajima²,

Hashimoto³

et al. 2014

OJMI

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Introduction: The purposes were to clarify the magnetic resonance imaging (MRI) findings of malignant ovarian lesions arising from endometriomas, and to compare the lesions' histopathology and MRI characteristics. Materials and Methods: Between May 2004 and December 2012, 140 patients, all of whom were diagnosed as having an endometrioma by using MR imaging, underwent surgery. We compared the MR characteristics including size and signal intensity of the tumor and mural nodules, the thickness of the septum, and the thickness of the wall with the pathological diagnoses. The attached angles of the mural nodules to the cyst wall were also evaluated. Results: Among the 179 lesions, preoperative MR imaging diagnosed 153 benign and 26 malignant. Based on the pathological results, 169 were diagnosed as benign and 10 were diagnosed as malignant. Finally, preoperative MR imaging correctly diagnosed 152 benign (group 1) and nine malignant (group 2), misdiagnosed 17 benign as malignant (group 3) and misdiagnosed one malignant as benign (group 4). As for mural nodules, there was a significant difference between groups 1 and 2 in the mean maximum diameter of the mural nodules. An acute attached angle was shown in 1 of 7 in group 1, in 11 of 16 in group 2, and in 14 of 22 in group 3. We also compared benign group with malignant group on the final pathological findings. As for mural nodules, there was a significant difference between groups 1 + 3 and group 2 in the mean maximum diameter of the mural nodules. On dynamic study, there were 22 enhanced mural nodules (75.9%) on group 1 + 3. Conclusion: Most of endometriomas preoperatively diagnosed as benign were pathological benign lesions. Endometriomas that contain many enhanced mural nodules with papillary shape, larger size, M. Kohno et al. 143 showing hypointense on T1WI, hyperintense on T2WI and showing an acute attached angle may have malignant potential.

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“…Endometrioma may also present as multiple hyperintense foci on T1-WI in both ovaries. Malignant transformation of endometrioma especially to endometroid or clear cell adenocarcinomas are seen in only less than 1% of the cases, and appear as hypointense lesions on T2-WI with enhancing mural nodules [19].…”

Section: Endometriomamentioning

confidence: 99%

An Algorithm Based Approach To Ovarian Neoplasms

Mathew¹

2016

IJARS

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Introduction: Cancer of the ovaries is the 2 nd most common gynaecological malignancy and has the highest mortality rate among all gynaecological malignancies with an overall 5 year survival rate of 46%. A large number of the lesions are incidentally detected, for which imaging plays a vital role in treatment planning by characterizing these masses. Identifying benign lesions accurately may obviate unnecessary surgery, where as indeterminate or malignant lesions will require surgery with or without radio/chemotherapy. Aim:To inform the readers the imaging patterns of common and rarely encountered ovarian neoplasms and to provide an algorithm based approach to these ovarian lesions, which will not only aid in the management of these conditions but also obviate unnecessary investigations and surgeries. Materials and Methods:This was a prospective study conducted over a period of one year from January 2014 to January 2015 at the Department of Radiology, Father Muller Medical College, Mangalore, India. Data were collected from 82 patients who presented with ovarian cystic lesions on ultrasound and were either followed up by USG or underwent further evaluation by CT. Diagnosis was confirmed by histopathology. Statistical analysis involved percentage frequency.

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Ovarian Carcinoma in Patients with Endometriosis

Cited by 145 publications

References 17 publications

The shading sign: is it exclusive of endometriomas?

The shading sign: is it exclusive of endometriomas?

MR Differentiation of Endometriomas Complicated with and without Malignancy: Comparison with Pathological Findings

An Algorithm Based Approach To Ovarian Neoplasms

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