Ovarian carcinoma of hypercalcemic type: myoid features and lack of estrogen and progesterone receptors

Sinonasal SMARCB1 (INI1) Deficient Carcinoma With Yolk Sac Tumor Differentiation: Report of a Case and Comparison With INI1 Expression in Gonadal Germ Cell Tumors

“…11,13,14 Alternatively, YST differentiation can still reflect germ cell origin of SDC, like it was suggested recently for ovarian hypercalcemic-type small cell carcinoma, which is another neoplasm with loss of SWI/SNF component and with frequent rhabdoid morphology. [15][16][17] In such a case, a mutation of SMARC gene would be a secondary event in a germ cell-derived neoplasm. However, our finding of INI1 positivity in "common" gonadal germ cell tumors does not support this alternative explanation.…”

Small Cell Carcinoma of the Ovary (Hypercalcemic Type): Malignant Rhabdoid Tumor

“…BRG1 protein, a product of the SMARCA4 gene, is absent almost constantly [ 5 ]. In addition, expressions of p53, CD56, WT1, calretinin, CD10, ‘parathyroid-related’ polypeptide, and α-smooth muscle actin were described [ 3 , 8 ]. In cases with rhabdoid cytomorphology, the tumors were very similar to the so-called malignant rhabdoid tumor [ 9 ].…”

“…Therefore, some authors propose to rename SCCOHT as ‘malignant rhabdoid tumor of the ovary’ [ 4 , 5 ]. This view is supported by the following features shared by both SCCOHT and malignant rhabdoid tumor: occasional familial occurrence, frequent hypercalcemia, and immunohistochemical polyphenotypia [ 3 , 4 , 8 ]. It remains, however, to explain some findings which are not typical for rhabdoid tumor, such as mucinous glands, the common absence of rhabdoid cells, and findings of SMARC4 alterations in some neoplasms unrelated to rhabdoid tumor (pulmonary and pancreatic carcinomas, endometrioid carcinomas) [ 10 , 11 ].…”