Ovarian carcinoma screening in women at intermediate risk

Kauff, Noah D.; Hurley, Karen; Hensley, Martee L.; Lev, Gali; Goldfrank, Deborah J.; Castiel, Mercedes; Brown, Carol L.; Ostroff, Jamie S.; Offit, M.P.H. Kenneth; Barakat, Richard R.

doi:10.1002/cncr.21148

Cited by 23 publications

(14 citation statements)

References 50 publications

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“…This transient effect of an abnormal OCS result mirrors the findings of studies observing the psychological impact of familial breast screening [27,28] and the early studies of familial OCS which found no evidence of prolonged distress [13]. In contrast, Kauff et al [14] found reduced quality of life six months after receiving an abnormal result, which may reflect the high rate of false positive results and endometrial sampling observed in their study.…”

Section: Discussionsupporting

confidence: 49%

“…Total subscale scores yield cut-off values for mild (scores from 8 to 10), moderate (11)(12)(13)(14)(15) or severe (>16) depression or anxiety. The HADS showed strong reliability and validity in women at increased risk of breast cancer [26].…”

Section: General Anxiety and Depressionmentioning

confidence: 99%

“…In familial OCS, false positive results of ovarian scans have been associated with transient increases in anxiety compared to normal results [13]. A US study of women at increased familial risk found reduced quality of life six months after receiving an abnormal (yet benign) result of combined CA125 and TVS screening [14]. Population-based studies of the impact of abnormal OCS results show mixed findings [15][16][17].…”

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Psychological outcomes of familial ovarian cancer screening: No evidence of long-term harm

Brain

Lifford

Fraser

et al. 2012

Gynecologic Oncology

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Section: Discussionsupporting

confidence: 49%

Section: General Anxiety and Depressionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Psychological outcomes of familial ovarian cancer screening: No evidence of long-term harm

Brain

Lifford

Fraser

et al. 2012

Gynecologic Oncology

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“…also published on the impact of ovarian cancer screening on QOL. In this study of 135 patients, abnormal ovarian cancer screening results were associated with a significant decrease in the Mental Component Summary form of the SF-36 [6]. Finally, the Gynecologic Oncology Group (GOG) also published initial data regarding RRSO and CA-125 in women at risk for ovarian cancer (GOG 199) [7].…”

Section: Screening/early Diagnosismentioning

confidence: 99%

Health-related quality of life in ovarian cancer patients and its impact on clinical management

Chase

Wenzel

2011

Expert Review of Pharmacoeconomics & Outcomes Research

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Although the incidence of ovarian cancer is less than that of other female cancers, the morbidity and mortality associated with the disease course is high. Because treatment involves radical surgery and intense courses of chemotherapy, health-related quality of life (HRQOL) is often compromised. Most patients recur post-first-line therapy and undergo multiple rounds of chemotherapy. Thus, HRQOL is further disrupted. As the ongoing search for optima therapies in both the first-line and recurrent setting continues, much attention is paid towards clinical trial design and implementation. Over the last decade, patient-reported outcomes and HRQOL measurement have become an integral part of these trials. HRQOL data are valued in examining the extent of treatment benefit and therefore can aid in decision-making during active treatment and palliative care. HRQOL and patient-reported outcome measurement is also useful in determining symptom prevalence, severity and management. This article highlights the state of the science of HRQOL measurement in clinical trial design and outcomes. In addition, symptom management in ovarian cancer and its ability to modulate quality of life will be explored.

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“…Furthermore, OCS is associated with frequent false-positive screening test results and anxiety [17, 18]. More recently, the Risk of Ovarian Cancer Algorithm (ROCA), a novel screening strategy consisting of longitudinal CA-125 measurements analyzed by Bayesian modeling, followed by secondary screening with TVUS if indicated, has shown promise among average-risk [19], and high-risk women [20], with no clinically significant psychological morbidity among average-risk women undergoing repeat testing following abnormal screening tests [21].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with deciding between risk-reducing salpingo-oophorectomy and ovarian cancer screening among high-risk women enrolled in GOG-0199: An NRG Oncology/Gynecologic Oncology Group study

Phuong

Piedmonte

Han

et al. 2017

Gynecologic Oncology

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Objectives Women at increased genetic risk of ovarian cancer (OC) are recommended to have risk-reducing salpingo-oophorectomy (RRSO) after completion of reproductive planning. Effective screening has not been established, and novel screening modalities are being evaluated. Methods Participants chose either RRSO or a novel OC screening regimen (OCS) as their risk management option, and provided demographic and other data on BRCA mutation status, cancer worry, perceived intervention risks/benefits, perceived cancer risk, and quality-of-life at enrollment. We performed univariate and multivariate analyses to evaluate factors influencing decision between RRSO and OCS. Results Of 2,287 participants enrolled, 904 (40%) chose RRSO and 1,383 (60%) chose OCS. Compared with participants choosing OCS, participants choosing RRSO were older (p<0.0001), more likely to carry deleterious BRCA1/2 mutations (p<0.0001), perceive RRSO as effective, be more concerned about surgical harms and OCS limitations, and report higher perceived OC risk and OC-related worry. OCS participants were more likely to perceive screening as effective, be more concerned about menopausal symptoms, infertility, and loss of femininity, and report better overall quality-of-life. Twenty-four percent of participants believed they would definitely develop OC, and half estimated their lifetime OC risk as >50%, both higher than objective risk estimates. Conclusions Cancer worry, BRCA1/2 mutation status, and perceived intervention-related risks and benefits were associated with choosing between RRSO and OCS. Efforts to promote individualized, evidence-based, shared medical decision-making among high-risk women facing management choices should focus on conveying accurate OC risk estimates, clarifying the current understanding of intervention-related benefits and limitations, and addressing OC worry.

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Ovarian carcinoma screening in women at intermediate risk

Cited by 23 publications

References 50 publications

Psychological outcomes of familial ovarian cancer screening: No evidence of long-term harm

Psychological outcomes of familial ovarian cancer screening: No evidence of long-term harm

Health-related quality of life in ovarian cancer patients and its impact on clinical management

Factors associated with deciding between risk-reducing salpingo-oophorectomy and ovarian cancer screening among high-risk women enrolled in GOG-0199: An NRG Oncology/Gynecologic Oncology Group study

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