Ovarian Disorders of Pregnancy

Solitary Luteinized Follicle Cyst of Pregnancy

“…1 Unlike pregnancy luteomas and hyperreactio luteinalis, this lesion is rarely, if ever, responsible for androgenic manifestations in the mother and/or fetus. 1,7 Classically, the enlarged ovary contains a solitary, variably sized, unilocular, thin-walled cyst. If the cyst is large, only a small amount of normal ovarian parenchyma remains, probably due to stromal attenuation or pressure atrophy.…”

“…The differential diagnoses include a solitary follicular cyst not otherwise specified, corpus luteum cyst of pregnancy, pregnancy luteoma, hyperreactio luteinalis, 7,8 giant theca lutein cysts, unilocular cystic tumors of the common epithelial types and seen, with an average of two to three mitoses per 10 high power fields. 7 Aspiration yields a minimal amount of blood or colorless material with marked cellularity.…”

“…Histologically, multiple large follicle cysts demonstrating striking luteinization of their theca cells and corpora lutea are seen. 7 The intervening ovarian stroma is markedly edematous. Hemorrhage into the cysts is a common finding.…”

Bilateral serous cystadenofibromas clinically simulating hyperreactio luteinalis following controlled ovarian hyperstimulation and in vitro fertilization

“…Hyperreactio luteinalis (HL) is the second most common ovarian disorder of pregnancy after luteoma of pregnancy and is characterized by bilateral cystic enlargement of ovaries (1). The ovaries may be moderately to massively enlarged by multiple luteinized follicle cysts, secondary to stimulation with hCG and gonadotropins (2).…”

“…Various culture vessels are used in the performance of in vitro fertilization (IVF; organ culture dishes, petri dishes, tissue culture tubes), while varying volumes of culture media (microdrops to 3.0 ml) are used for oocyte insemination (1). The choice of which culture vessel and insemination medium volume are used is controlled, at least in part, by practical aspects.…”