Ovarian Dysgerminoma: A Tertiary Center Experience

Kılıç, Çiğdem; Çakır, Caner; Yüksel, Dilek; Kılıç, Fatih; Kayıkçıoğlu, Fulya; Koç, Sevgi; Korkmaz, Vakkaş; Cömert, Günsu Kimyon; Türkmen, Osman; Boran, Nurettin; Turan, Taner

doi:10.1089/jayao.2020.0087

Cited by 12 publications

(35 citation statements)

References 21 publications

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“…Killic et al conducted a study that included 18 ovarian dysgerminoma patients with staging laparotomy concluded that fertility sparing surgery should be the choice of treatment in patients with pure ovarian dysgerminoma. 8 In addition, staging surgery, including retroperitoneal lymph node dissection is obligatory for determining stage IA patients who are exempt from adjuvant chemotherapy. Close surveillance policy enables early detection of patients with recurrences in whom salvage therapy is highly curable.…”

Section: Discussionmentioning

confidence: 99%

Misleading Diagnosis of Dysgerminoma in a Young Asymptomatic Patient

Maharjan

Bajracharya

Dangal

et al. 2020

Kathmandu Univ. Med. J.

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Dysgerminomas account for approximately one third of all malignant ovarian germ cell tumors (tumors arising from ovarian germinal elements) and are the most common ovarian malignancy detected during pregnancy. They are the only germ cell malignancy with a significant rate of bilateral ovarian involvement that is 15-20 percent. They have a variable gross appearance, but in general are solid, pink to tan to cream colored lobulated masses. They have the best prognosis of all malignant ovarian germ cell tumor variants. Two thirds are stage I at diagnosis, and prognosis is excellent even for those with advanced disease due to exquisite tumor chemosensitivity. The 5 year disease specific survival rate approximates 99 percent. This is a case report of a huge ovarian dysgerminoma in a young unmarried lady that was quite asymptomatic. She underwent laparotomy with right ovarian cystectomy.

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Section: Discussionmentioning

confidence: 99%

Misleading Diagnosis of Dysgerminoma in a Young Asymptomatic Patient

Maharjan

Bajracharya

Dangal

et al. 2020

Kathmandu Univ. Med. J.

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“…Symptoms of this disease are pelvic pain, tumoral mass with abdominal distention, amenorrhea, sometimes bleeding and compression of the neighboring organs, but it can also be asymptomatic, as in our case [ 2 , 7 , 9 , 13 ]. However, the main symptom is represented by pelvic and abdominal pain, which can be acute, in the case of rupture, torsion or hemorrhage [ 7 , 11 , 16 , 17 , 18 , 19 ]. Family history is usually insignificant for this pathology [ 20 ]; moreover, the family history of cancer inversely correlates with the development of germ cell tumors [ 9 ].…”

Section: Diagnosismentioning

confidence: 99%

“…In some cases, these extensive interventions are even abandoned when fertility preservation is desired [ 8 ]. In some studies, lymphadenectomy and omentectomy are even recommended as the first intention [ 19 ], but this is not supported by the majority of studies [ 7 , 8 , 17 ]. The postoperative outcome is adequate.…”

Section: Managementmentioning

confidence: 99%

“…This amalgam of associations further complicates a rare pathology that is difficult to frame anyway. We chose to review the possible associations [ 9 , 18 , 19 , 34 , 35 , 36 ].…”

Section: Other Ovarian Malignant Germ Cell Tumors Differentiation And...mentioning

confidence: 99%

“…So an important issue is BEP long-term toxicity and how to reduce it. Another problem is that, even if ESGO does not recommend lymph node dissection in every stage of disease, Cigen Kilic et al performed this procedure in every surgery they made, according to their study from 2021 [ 19 ]. Thus, correct management is still an issue.…”

Section: Coherent Management Guidelines—a Necessitymentioning

confidence: 99%

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Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors

et al. 2022

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Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the preservation of fertility. Even if a multidisciplinary team, founded in 2009 by a gynecologist, an oncologist, a pediatric oncologist and a pediatric surgeon, under the guidance of the Malignant Germ Cell International Consortium (MaGIC), studies this type of tumor, issues still remain related to the lack of a randomized study and to both the management and understanding of the concept of OMGCTs (ovarian malignant germ cell tumors). The aim of this review is to present from the literature the various approaches for this type of tumor, and, regarding innovative therapies or possible prevention, which can be applied in clinical practice. Multidisciplinarity and treatment in reference centers have proven their usefulness as well.

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Spontaneous pregnancy after fertility‐sparing surgery and adjuvant chemotherapy for advanced pure dysgerminoma: A case report

Göç,

Kastrati

et al. 2024

Clinical Case Reports

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Key Clinical MessageFertility‐sparing surgery and appropriate adjuvant chemotherapy for advanced malignant ovarian germ cell tumors have excellent survival results and promising reproductive and obstetric outcomes.AbstractThis case report aims to demonstrate the potential feasibility and success of fertility‐sparing surgery (FSS) coupled with adjuvant chemotherapy in treating advanced malignant ovarian germ cell tumor (MOGCT), focusing on pure dysgerminoma, fertility, and achieving spontaneous pregnancy. The patient was a 23‐year‐old female who initially presented with complaints of abdominal distension and a palpable mass and was subsequently diagnosed with advanced MOGCT. The patient provided a complete clinical and radiological response to FSS with complete surgical staging and cisplatin‐based chemotherapy (bleomycin, etoposide, and cisplatin). Despite being diagnosed with advanced MOGCT and treated with FSS and adjuvant chemotherapy, she later experienced spontaneous pregnancy, giving birth to a healthy child. This case study demonstrated the potential for successful fertility preservation and pregnancy in advanced‐stage MOGCT patients treated with personalized treatment approaches. Nevertheless, a broader investigation is needed to understand the relevant complex dynamics and to ascertain whether FSS with adjuvant chemotherapy could be a reliable approach in treating advanced MOGCT.

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Ovarian Dysgerminoma: A Tertiary Center Experience

Cited by 12 publications

References 21 publications

Misleading Diagnosis of Dysgerminoma in a Young Asymptomatic Patient

Misleading Diagnosis of Dysgerminoma in a Young Asymptomatic Patient

Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors

Spontaneous pregnancy after fertility‐sparing surgery and adjuvant chemotherapy for advanced pure dysgerminoma: A case report

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