Ovarian dysgerminoma metastatic to the breast

Kattan, Joseph; Droz, Jean‐Pierre; Charpentier, P; Michel, G; Lhommé, C.; Boutan-Laroze, Arnaud; Prade, M

doi:10.1016/0090-8258(92)90204-v

Cited by 14 publications

(9 citation statements)

References 13 publications

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“…As in our series, the most commonly reported gynecologic cancer to metastasize to the breast is serous carcinoma. [7][8][9] Other unusual gynecologic tumors reported to have metastasized to the breast included endometrial stromal sarcoma, 14 ovarian clear cell carcinoma, 7 ovarian granulosa cell tumor 15 ovarian dysgerminoma 16 and choriocarcinoma. 5 The current study included one ovarian clear cell carcinoma and one choriocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Non-mammary metastases to the breast and axilla: a study of 85 cases

et al. 2013

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Non-mammary metastases to the breast and axilla are rare occurrences. However, they are important diagnostic considerations as their treatment and prognosis differ significantly from primary breast cancer. Between 1990 and 2010, we identified a total of 85 patients, 72 women and 13 men, with non-mammary malignancies involving the breast, axilla, or both. The tumor types consisted of carcinoma (58%), melanoma (22%) and sarcoma (20%). Ovary was the most common site of origin for carcinoma, and metastatic high-grade ovarian serous carcinoma was most frequently misdiagnosed as a primary breast carcinoma. Melanoma was the single most common non-carcinomatous tumor type to involve the breast and/or axilla, and uterine leiomyosarcoma was the most common type of sarcoma. Most patients (77%) had other metastases at the time of diagnosis of the tumor, but in 11% the breast or axillary lesion was the first presentation. Without a clinical history, non-mammary metastases were difficult to diagnose because the majority of cases presented with a solitary nodule and lacked pathognomonic pathologic features. There were, however, certain recurrent histological findings identified, such as the often relatively well-circumscribed growth pattern of the metastatic lesion surrounded by a fibrous pseudocapsule, and the absence of an in situ carcinoma. Overall, these patients had poor survival; 96% of patients with follow-up available are dead of disease, with a median survival of 15 months after the diagnosis of the breast or axillary lesion. This finding emphasizes the need to accurately identify these tumors as metastases in order to avoid unnecessary procedures and treatments in these patients. Keywords: axilla; breast; extramammary Metastases to the breast and axilla are rare and account for approximately 2% of all mammary malignancies. 1,2 The most common metastatic lesion to involve the breast is a metastasis from a contralateral mammary cancer. 1,2 If hematologic malignancies are also excluded, the number of non-mammary metastases drops to well below 1%. 1,3 Owing to the frequency of primary breast cancers and the rarity of non-mammary tumors involving the breast, a newly discovered lesion in the breast or axilla is usually presumed to be a primary or metastatic breast carcinoma. However, the recognition of non-mammary metastases to the breast and axilla is very important, as both the treatment and prognosis differ significantly. Materials and methodsAfter obtaining approval by our Institutional Review Board, we searched the pathology database of Memorial Sloan-Kettering Cancer Center between the years 1990-2010 for patients with non-mammary metastases to the breast and axilla. Hematologic malignancies were excluded, as they are systemic diseases. The medical records and pathology slides, when available, were reviewed and the clinicopathologic characteristics were recorded. Patient age, gender, primary tumor site, the presence of other metastases, laterality, number of lesions, interval from primary tumor diagnosis to breast/ a...

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Section: Discussionmentioning

confidence: 99%

Non-mammary metastases to the breast and axilla: a study of 85 cases

et al. 2013

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“…In addition, the cell fragments and cell clusters usually consist of uniform, small, well-differentiated tumor cells lacking the high nuclear grade and hobnail nuclei. 13 In our case the differential diagnosis included the medullary carcinoma of the breast, which appears high cellularity with clusters and single intact malignant cells, bizarre stripped nuclei with prominent nucleoli in a lymphoplasmacytic background similar to the texture of a lymph node.…”

Section: Cytologic and Pathologic Findingsmentioning

confidence: 72%

“…Axillary metastases of ovarian carcinoma are usually associated with breast metastases, 3,4 but they have been occasionally detected without breast involvement. 5,6 The most common type of ovarian malignancy metastasizing to the axillary lymph node is serous carcinoma, [7][8][9] Less common types based on the literature are endometrioid adenosquamous carcinoma, 10 poorly differentiated carcinoma, 11 clear-cell carcinoma, 12 and dysgerminoma 13 (Table I). The cytological spectrum of the differential diagnosis of a metastatic ovarian carcinoma in axillary lymph node principally should include breast carcinomas.…”

Section: Cytologic and Pathologic Findingsmentioning

confidence: 99%

Ovarian carcinoma presenting with axillary lymph node metastasis: A case diagnosed by fine‐needle aspiration and brief review of the literature

Σκάγιας

Ntinis

Vasou

et al. 2008

Diagnostic Cytopathology

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Ovarian carcinoma is a lethal disease and a main cause of morbidity and mortality among gynecological malignancies. Metastatic ovarian carcinoma to the axillary node is an exceptionally infrequent pathological entity. We report a case of ovarian carcinoma, which presented with axillary lymph node metastasis and review the previously documented cases. A 63-year-old woman with a medical history of stage IIIb ovarian carcinoma was admitted to our hospital complaining of a mass in her right axilla. Fine-needle aspiration (FNA) biopsy was performed. Cytological examination revealed a poorly differentiated carcinoma with immunocytochemical features consistent with metastatic ovarian carcinoma. This case illustrates a rare presentation of ovarian carcinoma and underlines the need to consider it in the differential diagnosis of axillary lesions.

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“…There are 35 published literatures of breast metastasis from ovarian carcinoma between 1981 and 2019, ranging from 14 to 81 years old (Table 1 ). Thirty cases of ovarian tumors metastasizing to breast were serous carcinoma, [ 2 , 7 – 29 ] 2 cases were carcinoid tumor, [ 30 , 31 ] 2 cases were clear-cell carcinoma, [ 32 , 33 ] 2 cases were borderline tumor, [ 20 , 34 ] 2 cases were small cell carcinoma, [ 35 , 36 ] 1 was mucinous tumor of low malignant potential, [ 37 ] 1 was dysgerminoma, [ 38 ] 1 was granulosa cell tumor [ 39 ] and 1 was endometrioid carcinoma. [ 40 ] Thirty-one cases (73.2%) of these patients with breast metastasis had the history of ovarian carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Metastatic serous borderline tumor with micro-invasive ovarian carcinoma presenting as a breast lump

Dong¹,

Xie²,

Xue³

et al. 2020

Medicine

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Rationale: Breast metastasis from serous borderline tumor with micro-invasive carcinoma of ovary is a very rare condition. The breast lump as the only clinical presentation is rarely seen in ovarian carcinoma, which may lead to be misdiagnosed, and the mechanism of breast metastasis from ovarian tumors in early stage still needs to be explored. Differentiation from primary breast cancer and extramammary malignancy is crucial because the treatment and prognosis are significantly different. Patient concerns: A 33-year-old female presented with a painless, movable, 1.0 × 1.0 cm lump in the upper outer quadrant of the right breast for a month. Diagnoses: Breast metastasis of serous borderline tumor with micro-invasive ovarian carcinoma confirmed by pathology and immunohistochemistry. Interventions: The patient underwent lumpectomy, bilateral ovarian tumor stripping operation and prophylactic chemotherapy. Outcomes: No signs of recurrence have been detected in 1.5 years of follow-up. Lessons: Distant metastasis may occur in early stage of ovarian carcinoma. It is important to determine the origin of the primary tumor and develop an effective treatment strategy for patients. Imaging findings and pathological diagnostic criteria are important to accurately differentiate between metastasis and primary breast lesions, which may improve the patient's outcomes.

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Ovarian dysgerminoma metastatic to the breast

Cited by 14 publications

References 13 publications

Non-mammary metastases to the breast and axilla: a study of 85 cases

Non-mammary metastases to the breast and axilla: a study of 85 cases

Ovarian carcinoma presenting with axillary lymph node metastasis: A case diagnosed by fine‐needle aspiration and brief review of the literature

Metastatic serous borderline tumor with micro-invasive ovarian carcinoma presenting as a breast lump

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