Ovarian dysgerminoma showing high serum levels and positive immunostaining of placental alkaline phosphatase and neuron-specific enolase associated with elevation of serum prolactin level

Laparoscopic Management of Ovarian Dysgerminoma Presenting with Acute Abdomen Caused by Adnexal Torsion in a 17-Year-Old Girl

“…These tumors are also characterized by infiltrating channels of lymphocytes admixed with connective tissue stroma. The presence of placental alkaline phosphatase-positive cells demonstrated in tumor tissue by immunohistochemistry aids the diagnosis, 12 as in the present case.…”

Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell tumours

“…NSE is present in all neurons and is therefore recognised as a molecular marker of neuroendocrine tissue (22). In the literature, NSE has been described in the context of mature teratomas, immature teratomas, and dysgerminomas (23). These tumour markers may also be useful in our patient's clinical follow-up and offer more specific, individualised monitoring.…”

Pediatric ovarian dysgerminoma with highly elevated serum neuron‐specific enolase

“…and Yoshida et al . reported similar cases of dysgerminoma, in which serum NSE increased prior to surgery but normalized immediately after resection . In these seven reported cases of dysgerminoma with high serum NSE, the median value before tumor resection was 64 ng/mL (range, 24–199.5 ng/mL).…”

“…In patients with dysgerminoma, the ovarian counterpart of testicular seminoma, serum lactic dehydrogenase (LDH; mainly isozymes 1 and 2) and cancer antigen 125 (CA‐125) are usually elevated, whereas human chorionic gonadotropin (hCG) and placental alkaline phosphatase (PLAP) are rarely elevated. α‐Fetoprotein, however, is normal . Serial measurement of these markers can be useful for monitoring disease.…”

“…Serial measurement of these markers can be useful for monitoring disease. Few reports describe neuron‐specific enolase (NSE) as a tumor marker for dysgerminoma …”