Ovarian Dysgerminoma with Massive Metastases to Para-Aortic Lymph Nodes

Abstract

We report on a 15-year-old female with left ovarian dysgerminoma accompanied by massive swelling of the para-aortic lymph nodes which was clearly demonstrated by preoperative magnetic resonance imaging (MRI). Metastasis to the para-aortic lymph nodes from dysgerminoma was confirmed by biopsies obtained during surgery. No study has previously reported dysgerminoma with massive para-aortic lymph node metastases clearly demonstrated by MRI. These preoperative MRI findings are presented here. The patient received six cycles of cisplatin-based combination chemotherapy with the BEP regimen (bleomycin, etoposide and cisplatin) after conservative surgery, and no residual para-aortic lymph nodes were detected by MRI or CT after the chemotherapy.

Excision of extensive metastatic dysgerminoma to control refractory hypercalcaemia in a child at high risk for tumour-lysis syndrome

“…Since dysgerminomas produce humoral factors to drive hypercalcaemia, excision of even metastatic disease remains a rational strategy to control this [6,14]. Takemori et al described the massive para-aortic disease that can accompany dysgerminoma (albeit without hypercalcaemia in that case) [15]. Our CT scans indicated, that though large, the three masses were localized and not particularly infiltrative in appearance.…”

Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature

“…The most common metastases of dysgerminoma are the peritoneal cavity, omentum (86%), pelvis and abdomen [11,23], and retroperitoneal lymph node [11,23,24]. Furthermore, extra-abdominal lymph nodes such as para-aortic, [23,25,26], supraclavicular [11] and cervical lymph nodes [26][27][28] may be involved. Distant hematogenous metastases develop in the bones [29][30][31], lungs (15%) [24], liver [29,31], kidneys [29], adrenal glands [31], mammary glands [32], cranium, brain, dura mater and intra-axial [24,33,34], pancreas [29], heart and skin [32].…”

Para-Aortic Ln Involved Dysgerminoma Masquerading as Myoma During Pregnancy: Case Study

“…Dysgerminoma is the most common ovarian germ cell tumor and accounts for 3-5% of all ovarian malignancies [5]. Diagnosing ovarian germ cell tumors is challenging [6].…”