2023
DOI: 10.1186/s12915-023-01773-1
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Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1

Madeleine Birgersson,
Rajitha Indukuri,
Linnéa Lindquist
et al.

Abstract: Background Estrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of action is mainly uncharacterized. Results We here performed ERβ ChIP-sequencing of mouse ovaries followed by complementary RNA-sequencing of wild-type and ERβ knockout ovaries. By integrating the ERβ cistrome and transcriptome, we identified its direct target genes and enriched biological functions in the ovary. This demo… Show more

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