Ovarian Fibroma With Bizarre Nuclei: A Rare Finding

Salibay, Christine; Fadare, Oluwole

doi:10.1177/1066896920919988

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…Verocay-like areas, bizarre nuclei, lutein cells, signet-ring-like cells, histiocytes as well as hyaline bodies (of the type seen in yolk sac tumor and many other neoplasms) and more particularly, in our experience small, delicate intracytoplasmic hyaline droplets which may become extracellular and be confluent (Fig. 1D); rarely melanin pigment may be seen 24,35–38 . Areas of infarction can be conspicuous in large tumors.…”

Section: Fibromasupporting

confidence: 50%

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Sex Cord–Stromal Tumors of the Ovary: An Update and Review. Part I — Pure Ovarian Stromal Tumors

Devins,

Young,

Oliva

2024

Advances in Anatomic Pathology

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In two separate reviews, we reviews the time-honored but still frequently challenging features of ovarian sex cord–stromal tumors, and also emphasize new developments including unusual morphologic appearances that, despite the relative rarity of many of the tumors, result in a disproportionate number of differential diagnostic problems, variant immunohistochemical profiles, and specific molecular and syndromic associations. These neoplasms are also of historical interest as current knowledge is still based in significant part on the contributions of 2 giants of gynecologic pathology, Dr Robert Meyer and Dr Robert E. Scully. In part I, we present the major clinical, pathologic, and genomic features of the pure ovarian stromal tumors including comments on differential diagnosis and briefly note significant historical contributions. In part II we will discuss pure sex cord and sex cord–stromal tumors.

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Section: Fibromasupporting

confidence: 50%

“…1D); rarely melanin pigment may be seen. 24,[35][36][37][38] Areas of infarction can be conspicuous in large tumors.…”

Section: Fibromamentioning

confidence: 99%

Sex Cord–Stromal Tumors of the Ovary: An Update and Review. Part I — Pure Ovarian Stromal Tumors

Devins,

Young,

Oliva

2024

Advances in Anatomic Pathology

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“…The presence of few areas containing sheets or nodules of plump and round to spindle-shaped cells with clear/vacuolated cytoplasm resembling perifollicular thecal cells [27] could correspond to thecomatous cells, while no threshold of thecomatous cells is currently defined to diagnose fibroma vs. thecoma. Few eosinophilic hyaline globules stained with periodic acid-Schiff (PAS) [28], hyalinized plaques, edematous remodeling, or calcifications [8,21], Verocay-like features [19], bizarre nuclei [29], or even a few microscopic foci of hemorrhage may be observed [19]. While ischemic necrosis from infarction of voluminous tumors may be seen [30], the presence of tumor cell necrosis is very uncommon and should raise the suspicion of fibrosarcoma [8,19,26].…”

Section: Design Of the Present Review: From Cell Morphology To Molecu...mentioning

confidence: 99%

Relevance of Molecular Pathology for the Diagnosis of Sex Cord–Stromal Tumors of the Ovary: A Narrative Review

Trecourt,

Donzel,

Alsadoun

et al. 2023

Cancers

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Ovarian sex cord–stromal tumors (SCSTs) account for 8% of all primary ovarian neo-plasms. Accurate diagnosis is crucial since each subtype has a specific prognostic and treatment. Apart from fibrosarcomas, stromal tumors are benign while sex cord tumors may recur, sometimes with a significant time to relapse. Although the diagnosis based on morphology is straightforward, in some cases the distinction between stromal tumors and sex cord tumors may be tricky. Indeed, the immunophenotype is usually nonspecific between stromal tumors and sex cord tumors. Therefore, molecular pathology plays an important role in the diagnosis of such entities, with pathognomonic or recurrent alterations, such as FOXL2 variants in adult granulosa cell tumors. In addition, these neoplasms may be associated with genetic syndromes, such as Peutz–Jeghers syndrome for sex cord tumors with annular tubules, and DICER1 syndrome for Sertoli–Leydig cell tumors (SLCTs), for which the pathologist may be in the front line of syndromic suspicion. Molecular pathology of SCST is also relevant for patient prognosis and management. For instance, the DICER1 variant is associated with moderately to poorly differentiated SLCTS and a poorer prognosis. The present review summarizes the histomolecular criteria useful for the diagnosis of SCST, using recent molecular data from the literature.

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Ovarian Fibroma With Bizarre Nuclei: A Rare Finding

Cited by 2 publications

References 10 publications

Sex Cord–Stromal Tumors of the Ovary: An Update and Review. Part I — Pure Ovarian Stromal Tumors

Sex Cord–Stromal Tumors of the Ovary: An Update and Review. Part I — Pure Ovarian Stromal Tumors

Relevance of Molecular Pathology for the Diagnosis of Sex Cord–Stromal Tumors of the Ovary: A Narrative Review

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