Ovarian Follicular Concentrations of Activin, Follistatin, Inhibin, Insulin-Like Growth Factor I (IGF-I), IGF-II, IGF-Binding Protein-2 (IGFBP-2), IGFBP-3, and Vascular Endothelial Growth Factor in Spontaneous Menstrual Cycles of Normal Women of Advanced Reproductive Age

Klein, N. A.

doi:10.1210/jc.85.12.4520

Cited by 46 publications

(40 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could be the result of increased FSH stimulation of granulosa cells in older women. The occurrence of normal concentrations of oestradiol and inhibins in the follicular fluid of pre-ovulatory follicles in older women is also in line with the assumption that the observed reduction in serum inhibin B levels in older women is the result of a decreased number of antral follicles, rather than reduced granulosa cell secretory capacity [81,90,91].…”

Section: Menopausesupporting

confidence: 79%

Reproductive ageing in women

Djahanbakhch

Ezzati

Zosmer

2007

The Journal of Pathology

View full text Add to dashboard Cite

The traditional view in respect to female reproduction is that the number of oocytes at birth is fixed and continuously declines towards the point when no more oocytes are available after menopause. In this review we briefly discuss the embryonic development of female germ cells and ovarian follicles. The ontogeny of the hypothalamic-pituitary-gonadal axis is then discussed, with a focus on pubertal transition and normal ovulatory menstrual cycles during female adult life. Biochemical markers of menopausal transition are briefly examined. We also examine the effects of age on female fertility, the contribution of chromosomal abnormalities of the oocyte to the observed decline in female fertility with age and the possible biological basis for the occurrence of such abnormalities. Finally, we consider the effects of maternal age on obstetric complications and perinatal outcome. New data that have the potential to revolutionize our understanding of mammalian oogenesis and follicular formation, and of the female reproductive ageing process, are also briefly considered.

show abstract

Section: Menopausesupporting

confidence: 79%

Reproductive ageing in women

Djahanbakhch

Ezzati

Zosmer

2007

The Journal of Pathology

View full text Add to dashboard Cite

show abstract

“…Because the oocytes pool size cannot be directly measured in women, the size of the ovarian pool that contributes to the incidence of aneuploidy is an intrinsically difficult association to resolve. It is known that the average age at menopause among women with trisomic spontaneous abortions (SAs) is 1 year earlier compared to women with chromosomally normal pregnancies [47]. As we know, menopause occurs when the oocyte pool falls below a critical threshold, and this observation is consistent with the oocyte pool hypothesis.…”

Section: Disscussionmentioning

confidence: 54%

The association between the oocyte pool and aneuploidy: a comparative study of the reproductive potential of young and aged mice

Cheng

Hou

et al. 2013

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The present study examined the effect of aging on female reproductive potential. Methods Six-week-old and 9-month-old CD1 mice were referred to as the 'young' and 'aged' groups, respetively. Oocytes were collected after superovulation, and their viability were compared using parthenogenetic activation. The aneuploidy of the oocytes (MII) was assessed using chromosome spread, and the whole ovarian follicle number was counted using an unbiased stereological method. Serum hormone levels were measured using the radio-immunity method, and the expression of the Cohesin subunit genes in the oocytes (GV) were assessed using RT-PCR. Results The mean number of recovered (25.8 vs. 16.2; P<0.05) and live oocytes (24.0 vs. 11.73; P <0.01) per head in the young-mice group (6-week-old) was significantly higher than that of the aged group (9-month-old). The aneuploidy rate of the ovulated oocytes in the aged group was significantly higher than that of the young group (36.8 % vs. 10 %; P<0.01), and the rate of blastocyst formation in the young group (85.23 %) was significantly higher than that of the aged group (81.2 %; P <0.05). The number of primordial follicles (the oocyte pool) per ovary in the aged group was significantly decreased compared with the young group (330±33.51 vs. 2079.6±420.70; P<0.01), and the level of AMH in the aged group was significantly higher than that of the young group (4.66±0.11 ng/ml vs. 4.07±0.18 ng/ml; P<0.01). Conclusions We propose that maternal aging significantly reduces the oocyte pool, superovulation efficiency and developmental potential and increases the oocyte aneuploidy rate.

show abstract

“…This finding was also demonstrated by others that the administration of recombinant FSH could affect the follicular fluid concentration of IGFBP-3 However, the authors did not associate this peptide with another IVF outcome (12).…”

Section: Discussionmentioning

confidence: 62%

“…Moreover, IGFBP-3 follicular fluid concentration in older women did not differ from younger controls (12).…”

Section: Introductionmentioning

confidence: 68%

See 1 more Smart Citation

Insulin-like growth factor-1 and insulin-like growth factor binding protein-1 and 3 in the follicular fluid of infertile patients submitted to in vitro fertilization

Cunha-Filho

Lemos

Freitas

et al. 2005

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose : In the present article we propose to evaluate IGF-1, IGFBP-1 and 3 in the follicular fluid of infertile patients submitted to in vitro fertilization. Methods : We performed a case-control study with 53 infertile patients submitted to the first in vitro fertilization attempt. We compared their follicular fluid concentration of IGF-1, IGFBP-1 and IGFBP-3 between the patients who became pregnant (n = 11) versus those nonpregnant (n = 42). Results : The clinical characteristics of patients from the two groups were similar in terms of age and body mass index. Data related to the analysis of ovulation induction was not different regarding length of induction in days, number of retrieved oocytes, fertilization rate, and number of transferred embryos. Furthermore, the number of FSH units required for ovarian induction was also similar between the studied groups.IGF-1 and IGFBP-1 were not significantly different between the groups (p > 0.05). However, those patients that became pregnant presented a lower follicular fluid concentration of IGFBP-3, 2237.10 ± 582.73 pg/ml and 2657.64 ± 584.15 ng/ml, respectively (p = 0.038). Conclusions : We demonstrated an association of a lower follicular fluid IGFBP-3 in individuals that became pregnant compared to subjects that did not after in vitro fertilization.

show abstract

Ovarian Follicular Concentrations of Activin, Follistatin, Inhibin, Insulin-Like Growth Factor I (IGF-I), IGF-II, IGF-Binding Protein-2 (IGFBP-2), IGFBP-3, and Vascular Endothelial Growth Factor in Spontaneous Menstrual Cycles of Normal Women of Advanced Reproductive Age

Cited by 46 publications

References 19 publications

Reproductive ageing in women

Reproductive ageing in women

The association between the oocyte pool and aneuploidy: a comparative study of the reproductive potential of young and aged mice

Insulin-like growth factor-1 and insulin-like growth factor binding protein-1 and 3 in the follicular fluid of infertile patients submitted to in vitro fertilization

Contact Info

Product

Resources

About