Ovarian Follicular Dynamics: A Review with Emphasis on the Bovine Species. Part I: Folliculogenesis and Pre‐antral Follicle Development

Aerts, J.M.J.; Bols, P.E.J.

doi:10.1111/j.1439-0531.2008.01302.x

Cited by 91 publications

(63 citation statements)

References 100 publications

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“…15 Increased vascularity is a determining factor in the establishment of follicular dominance. 15 Consequently, angiogenic factors are of increasing interest in ovarian physiology. In particular, the role of VEGF has been studied extensively.…”

Section: Discussionmentioning

confidence: 99%

Bone Morphogenetic Protein 7 Increased Vascular Endothelial Growth Factor (VEGF)-A Expression in Human Granulosa Cells and VEGF Receptor Expression in Endothelial Cells

et al. 2014

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The formation of an individual capillary network in the theca cell layer is required for ovarian folliculogenesis. Although vascular endothelial growth factor (VEGF) is critical for this process, the regulation of VEGF has been unclear. In the present study, the relationship between VEGF and intraovarian cytokine, bone morphogenetic protein 7 (BMP-7) was investigated. Granulosa cells (GC), obtained from in vitro fertilization patients, were cultured with BMP-7 followed by RNA extraction. Human umbilical vein endothelial cells (HUVECs) were also cultured with BMP-7 followed by RNA extraction, tube formation assay, or cell count analysis. The BMP-7 stimulated VEGF messenger RNA (mRNA) and protein expression in GC significantly. In HUVEC, BMP-7 increased an approximately 1.8-fold in the cell number and induced the tube formation significantly compared to control. The BMP-7 also induced a 2-fold increase in VEGF receptor mRNA transcript relative abundance in HUVEC. The BMP-7, a theca cell-derived factor, may stimulate endothelial cell to form vasculature in the follicle via 2 distinct mechanisms, induction of VEGF expression in GC and increased sensitivity of endothelial cells to VEGF.

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Section: Discussionmentioning

confidence: 99%

Bone Morphogenetic Protein 7 Increased Vascular Endothelial Growth Factor (VEGF)-A Expression in Human Granulosa Cells and VEGF Receptor Expression in Endothelial Cells

et al. 2014

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“…Primordial follicles consist of an immature oocyte, arrested at prophase I of meiosis, surrounded by a single layer of somatic, granulosa cells (GC) [2]. By a mechanism that has yet to be well defined [3], a new cohort of these primordial follicles is constantly being activated to start their development, which progresses through a primary stage, a secondary stage and after around 140 days, in cows, eventually reach the antral stage.…”

Section: Introductionmentioning

confidence: 99%

Changes in granulosa cells gene expression associated with growth, plateau and atretic phases in medium bovine follicles

Douville

Sirard

2014

J Ovarian Res

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BackgroundThe objective of this study was to build the transcriptomic profile of granulosa cells originating from follicles 6 to 9 mm in diameter in dairy cattle using microarrays.MethodsGranulosa cells originating from three different phases of antral follicle growth were compared: growing (G), plateau (P) and atresia (A), as categorized by flow cytometry profiles of DNA. The growing and atretic conditions were each hybridized against the plateau condition as a reference in order to understand the specific biological mechanisms modulated in this class of follicles.Results2,942 genes were differentially expressed (P < 0.05) in P vs. G and 1,974 in A vs. P. A clear segregation of the 3 phases was confirmed by between group analysis (BGA). The first characteristic of the plateau phase is the activation of the upstream regulators TP53 and PTEN which participate in the reduction of cell growth through MYC, FOS and E2F1-2-3. We also observed the down-regulation of steroidogenesis genes: CYP11A1 and CYP19A1, in the granulosa cells of the plateau phase relative to the growth phase. On the other hand, the A vs. P contrast showed up-regulation of multiple transcripts associated to apoptosis: CCT2, DAB2, DSG2 and TGM2.ConclusionsThis study offers multiple candidate genes to be further studied in order to elucidate their role in the modulation of follicular development and, ultimately, of oocyte quality.

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“…The approach which attempted to optimize outcomes of ART and urgent fertility preservation based on the theory of ovarian follicular waves, such as synchronization of follicle wave emergence by different ways in ovarian stimulation, luteal phase oocyte retrieval, have been reported. However, to a large extent, the mechanisms of primordial follicle activation and antral follicular recruitment are far from being fully understood [49]. Further prospective studies are needed to confirm the findings.…”

Section: Discussionmentioning

confidence: 94%

Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction

Yang

Liu

et al. 2013

J Assist Reprod Genet

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Purpose To highlight recent progress in understanding the pattern of follicular wave emergence of human menstrual cycle, providing a brief overview of the new options for human ovarian stimulation and oocyte retrieval by making full use of follicular physiological waves of the patients either with normal or abnormal ovarian reserve. Methods Literature review and editorial commentary. Results There has been increasing evidence to suggest that multiple (two or three) antral follicular waves are recruited during human menstrual cycle. The treatment regimens designed based on the theory of follicular waves, to promote increased success with assisted reproduction technology (ART) and fertility preservation have been reported. These new options for human ovarian stimulation and oocyte retrieval by making full use of follicular waves of the patients either with normal or abnormal ovarian reserve lead to new thinking about the standard protocols in ART and challenge the traditional theory that a single wave of antral follicles grows only during the follicular phase of the menstrual cycle. Conclusions The understanding of human ovarian folliculogenesis may have profound implications in ART and fertility preservation. Further studies are needed to evaluate the optimal regimens in ART based on the theory of follicular waves and to identify non-invasive markers for predicting the outcome and the potential utilities of follicles obtained from anovulatory follicular waves in ART.

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Ovarian Follicular Dynamics: A Review with Emphasis on the Bovine Species. Part I: Folliculogenesis and Pre‐antral Follicle Development

Cited by 91 publications

References 100 publications

Bone Morphogenetic Protein 7 Increased Vascular Endothelial Growth Factor (VEGF)-A Expression in Human Granulosa Cells and VEGF Receptor Expression in Endothelial Cells

Bone Morphogenetic Protein 7 Increased Vascular Endothelial Growth Factor (VEGF)-A Expression in Human Granulosa Cells and VEGF Receptor Expression in Endothelial Cells

Changes in granulosa cells gene expression associated with growth, plateau and atretic phases in medium bovine follicles

Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction

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