Ovarian Folliculogenesis

Rimon-Dahari, Nitzan; Yerushalmi-Heinemann, Lia; Alyagor, Liat; Dekel, Nava

doi:10.1007/978-3-319-31973-5_7

Cited by 198 publications

(131 citation statements)

References 132 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…In mammals, the ovarian follicle consists of the oocyte and granulosa cells, which are surrounded by interstitial steroidogenic cells such as theca cells and ovarian interstitial gland cells [1, 2]. Forkhead box L2 (FOXL2) is known to play a central role in the differentiation and maintenance of granulosa cells in developing ovaries [3,4,5,6].…”

mentioning

confidence: 99%

Defects in the first wave of folliculogenesis in mouse XO ovaries

Miura

Murata

Harikae

et al. 2017

Journal of Reproduction and Development

View full text Add to dashboard Cite

In mouse ovaries, the first wave of folliculogenesis perinatally starts near the medullary region, which directs the initial round of follicular growth soon after birth. At the same time, cortical primordial follicles start forming in the ovarian surface region, and then some are cyclically recruited for the second and subsequent rounds of follicular growth. Recent studies suggest different dynamics between the first and subsequent waves of follicular growth in postnatal ovaries. However, the phenotypic differences between these phases remain unclear. Here, we show direct evidence that XO female mice, a murine model for Turner Syndrome, lack the first wave of folliculogenesis. Our histopathological analyses of XX and XO littermates revealed a lack of anti-Müllerian hormone (AMH)-positive primary follicles in the XO ovaries by 4 days post partum (dpp). This loss of first follicles was also confirmed by histological bioassay for SRY-dependent SOX9 inducibility, a specific marker for the first follicular granulosa cells. In contrast, cortical primordial follicles formed properly in XO ovaries, and some of them formed primary and secondary follicles in the subcortical region by 7 dpp. They rapidly developed into late antral follicles, showing similarities to XX littermate ovaries by 21 dpp. These results suggest distinct X-monosomy effects between the first and subsequent waves of follicular growth, highlighting the high susceptibility to elimination of XO oocytes in the first wave of mammalian folliculogenesis.

show abstract

mentioning

confidence: 99%

Defects in the first wave of folliculogenesis in mouse XO ovaries

Miura

Murata

Harikae

et al. 2017

Journal of Reproduction and Development

View full text Add to dashboard Cite

show abstract

“…In addition, factors produced by granulosa cells such as follistatin, inhibin bb, among others, are involved in the control of follicular development (Knight and Glister, 2006;Myers and Pangas, 2010;Emori and Sugiura, 2014). From the moment granulosa cells increase in number and new layers are formed around the oocyte, the follicle is termed secondary (Rimon-Dahari et al, 2016).…”

Section: Oocyte Development and Early Embryogenesismentioning

confidence: 99%

The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases

Chiaratti

Garcia

Carvalho

et al. 2018

Cell Biology International

View full text Add to dashboard Cite

Mitochondria play a fundamental role during development of the female germline. They are fragmented, round, and small. Despite these characteristics suggesting that they are inactive, there is accumulating evidence that mitochondrial dysfunctions are a major cause of infertility and generation of aneuploidies in humans. In addition, mitochondria and their own genomes (mitochondrial DNA-mtDNA) may become damaged with time, which might be one reason why aging leads to infertility. As a result, mitochondria have been proposed as an important target for evaluating oocyte and embryo quality, and developing treatments for female infertility. On the other hand, mutations in mtDNA may cause mitochondrial dysfunctions, leading to severe diseases that affect 1 in 4,300 people. Moreover, very low levels of mutated mtDNA seem to be present in every person worldwide. These may increase with time and associate with late-onset degenerative diseases such as Parkinson disease, Alzheimer disease, and common cancers. Mutations in mtDNA are transmitted down the maternal lineage, following a poorly understood pattern of inheritance. Recent findings have indicated existence in the female germline of a purifying filter against deleterious mtDNA variants. Although the underlying mechanism of this filter is largely unknown, it has been suggested to rely on autophagic degradation of dysfunctional mitochondria or selective replication/transmission of non-deleterious variants. Thus, understanding the mechanisms regulating mitochondrial inheritance is important both to improve diagnosis and develop therapeutic tools for preventing transmission of mtDNA-encoded diseases.

show abstract

“…It is commonly accepted that most antral follicles undergo atresia and die, whereas only a selected population responds to LH and ovulate [reviewed previously (3)(4)(5)]. A possible explanation for the excessive ovulation observed in cKO mice may be that a lower level of atresia brings about the presence of a higher number of antral follicles, which finally ovulate in response to exogenous hormonal treatment.…”

Section: The Number Of Atretic Antral Follicles In Cko Mouse Ovaries mentioning

confidence: 99%

“…Most follicles undergo atretic degeneration, and only a subset of antral follicles, known as dominant follicles, at each reproductive cycle will reach the preovulatory stage, respond to the LH surge, and subsequently ovulate, releasing a fertilizable oocyte. Remaining somatic cells in the raptured follicle will undergo terminal differentiation and form the corpus luteum (CL), which secretes progesterone that is necessary for maintaining pregnancy [previously reviewed (4, 5)].…”

mentioning

confidence: 99%

Vasorin: a newly identified regulator of ovarian folliculogenesis

et al. 2018

Self Cite

View full text Add to dashboard Cite

Members of the TGF-β superfamily take part in the control of folliculogenesis. Vasorin (Vasn) is a newly identified negative regulator of TGF-β signaling whose possible involvement in ovarian physiology has never been studied. Here, we demonstrate that Vasn is expressed in the ovary by somatic cells of follicles, and that its expression is up-regulated by LH. We established a conditional knockout (cKO) mouse model in which Vasn is deleted specifically in granulosa cells of growing follicles from the secondary stage onwards. Using this model, we show that, upon hormonal stimulation, follicle ovulation size is almost 2-fold higher. This enhanced ovulatory response is associated with overactivation of the TGF-β signaling pathway and a lower number of atretic antral follicles. Of importance, we demonstrate that the number of primordial follicles is reduced in prepubertal cKO mouse ovaries, which suggests that the production of VASN by growing follicles protects the ovarian reserve. Finally, analysis of systemic KO mice revealed that the ovarian reserve is almost 2.5-fold higher, which implies that Vasn may also play a role in primordial follicle formation. Overall, our findings reveal that Vasn is a new regulator that exerts an effect on several key ovarian functions, including folliculogenesis, maintenance of the ovarian reserve, and ovulation.-Rimon-Dahari, N., Heinemann-Yerushalmi, L., Hadas, R., Kalich-Philosoph, L., Ketter, D., Nevo, N., Galiani, D., Dekel, N. Vasorin: a newly identified regulator of ovarian folliculogenesis.

show abstract

Ovarian Folliculogenesis

Cited by 198 publications

References 132 publications

Defects in the first wave of folliculogenesis in mouse XO ovaries

Defects in the first wave of folliculogenesis in mouse XO ovaries

The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases

Vasorin: a newly identified regulator of ovarian folliculogenesis

Contact Info

Product

Resources

About