Ovarian Function Following Pelvic Irradiation in Prepubertal and Pubertal Girls and Young Adult Women

Abstract

All patients receiving > 15 Gy to the ovaries developed hormone failure. In one case of a patient receiving an ovarian dose of 15 Gy, hormone failure was not found. In case of pelvic irradiation excluding at least one ovary, approximately half of the patients developed ovarian dysfunction, probably also due to the effects of polychemotherapy.

Scattered Dose to Gonads and Associated Risks from Radiotherapy for Common Pediatric Malignancies

“…Destruction of the fixed pool of oocytes and subsequent ovarian failure in women < 40 years can occur after doses of 2,000 cGy [11,28]. Prepubertal and young adult patients receiving > 1,500 cGy to ovaries develop hormonal failure [22]. The maximum scattered dose to ovaries from pediatric radiotherapy was 62.4 cGy which should not be associated with any risk for permanent failure.…”

Intensified External-Beam Radiation Therapy Improves the Outcome of Stage 4 Neuroblastoma in Children > 1 Year with Residual Local Disease

“…External-beam radiation therapy (EBRT) proved effective in small series of localized neuroblastoma [7] and infants' neuroblastoma [24] but data in high-risk neuroblastoma are still limited [5,13,19]. Radiation can cause long-term effects like scoliosis, soft-tissue hypoplasia, hypothyroidism, and secondary malignant disease [1,11,14,21,23,24,26,30] and should, therefore, be applied only when clearly indicated.…”

Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation: a report of two successful cases

“…16 Also, Shuck et al 17 reported that all patients who received irradiation to the ovaries at greater than 15 Gy developed hormone failure. The radiation doses that cause 5 and 50% complications to the ovaries are about 3 and 10 Gy, respectively.…”