Ovarian Gene Transcriptional Responses To Antidepressant Drugs (Imipramine And Fluoxetine) In Female Wistar Rats

Abstract

This study was designed to investigate ovarian gene transcriptional responses to selected antidepressant drugs (imipramine and fluoxetine) in female rats. Fifteen female rats (120 – 140 g) were used for this study. Imipramine (0.71 mg/kg) and fluoxetine (0.57 mg/kg) were given orally for 50 days. The method of RT-PCR was employed to investigate the expressions of FSH-R, p53 and Bcl-2 genes. Graphics were generated as mean +/- SEM using GraphPad Prism version 8.0. Results of the study revealed that the FSH-R, p53 and Bcl-2 expressions were significantly (p<0.05) up-regulated in the imipramine-treated rats relative to their controls. Conclusively, it can be suggested that imipramine induced follicular growth and apoptosis in female Wistar rats.