Ovarian hormones and propensity to drug relapse: A review

Hudson, Amanda; Stamp, Jennifer A.

doi:10.1016/j.neubiorev.2010.05.001

Cited by 87 publications

(69 citation statements)

References 99 publications

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“…Moreover, a repeated restraint stress procedure increases c-Fos immunoreactivity in the amygdala to a larger extent in female than in male rats, an effect that may underlie behavioral responses to stressors and that is also abolished by ovariectomy (Khurana and Devaud, 2007;Phelps and LeDoux, 2005). Sex-linked differences in various effects of drugs of abuse are also reported (for a review see Hudson and Stamp, 2011). For instance, the pharmacological stressor yohimbine elicits higher levels of cue-induced reinstatement of cocaine-seeking behavior in female than in male rats.…”

Section: Summary Of the Resultsmentioning

confidence: 99%

CRF2 Receptor Deficiency Eliminates the Long-Lasting Vulnerability of Motivational States Induced by Opiate Withdrawal

Morisot

Rouibi

Contarino

2015

Neuropsychopharmacol

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Vulnerability to stressful life events is a hallmark of drug dependence that may persist long after cessation of drug intake and dramatically fuel key clinical features, such as deregulated up-shifted motivational states and craving. However, to date, no effective therapy is available for reducing vulnerability to stressful events in former drug users and drug-dependent patients, mostly because of poor knowledge of the mechanisms underlying it. In this study, we report that genetic inactivation of the stress-responsive corticotropin-releasing factor receptor-2 (CRF 2 − / − ) completely eliminates the reemergence of increased nonrewarded nose-pokes, reflecting up-shifted motivational states, triggered by ethological environmental stressors long after cessation of morphine administration in mice. Accordingly, CRF 2 receptor deficiency completely abolishes the increase in biomarkers of synthesis of major brain motivational substrates, such as ventral tegmental area (VTA) dopamine (DA) and amygdala γ-aminobutyric acid (GABA) systems, associated with the stress-induced reemergence of upshifted motivational states long after opiate withdrawal. Nevertheless, neither CRF 2 receptor deficiency nor long-term opiate withdrawal affects amygdala CRF or hypothalamus CRF expression, indicating preserved brain stress-coping systems. Moreover, CRF 2 receptor deficiency does not influence the locomotor or the anxiety-like effect of long-term opiate withdrawal. Thus, the present results reveal an essential and specific role for the CRF 2 receptor in the stress-induced reemergence of up-shifted motivational states and related alterations in brain motivational systems long after opiate withdrawal. These findings suggest new strategies for the treatment of the severe and longlasting vulnerability that inexorably follows drug withdrawal and hinder drug abstinence.

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Section: Summary Of the Resultsmentioning

confidence: 99%

CRF2 Receptor Deficiency Eliminates the Long-Lasting Vulnerability of Motivational States Induced by Opiate Withdrawal

Morisot

Rouibi

Contarino

2015

Neuropsychopharmacol

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Section: Sex Differences In Drug Abusementioning

confidence: 99%

“…(Kosten et al, 1993;Hudson and Stamp, 2011). Various hypotheses have been proposed, from increased withdrawal responses (see above) to increased reactivity to internal (emotional) cues (negative reinforcement) to increased sensitivity to external (drug-associated) cues (positive reinforcement; Hudson and Stamp, 2011). For alcohol, cocaine, and nicotine, stress-induced relapse is a greater risk for women than for men (Kennedy et al, 2013;al'Absi et al, 2015;Torres and O'Dell, 2015).…”

Section: Sex Differences In Drug Abusementioning

confidence: 99%

“…In preclinical research, there is enhanced drug-, cue-, and stress-induced reinstatement in animals models of alcohol and drug seeking in females compared with males Hudson and Stamp, 2011). Animal models of craving, representing the preoccupation/anticipation stage of drug addiction, involve the reinstatement of drug-seeking behavior after extinction training and subsequent exposure to the drugs themselves, cues/contexts that are paired with drug self-administration, or stressors (Self, 1998;Shaham et al, 2003).…”

Section: Sex Differences In the Preoccupationmentioning

confidence: 99%

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Sex Differences in Animal Models: Focus on Addiction

2016

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“…In general, this literature suggests that estradiol enhances reward and facilitates reinstatement whereas progesterone dampens drug-seeking behavior. [14][15][16][17] The implications of this literature specifically for nicotine-related addiction remains in question as most of the existing studies have focused on cocaine. While a similar emphasis on cocaine exists in the modest human laboratory research on this topic, there are five studies involving smokers that are relevant because they are largely consistent with the generality noted here.…”

Section: Introductionmentioning

confidence: 99%

Increasing Progesterone Levels Are Associated With Smoking Abstinence Among Free-Cycling Women Smokers Who Receive Brief Pharmacotherapy

Saladin

McClure

Baker

et al. 2015

Nicotine & Tobacco Research

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Introduction: Preclinical and human laboratory research suggests that (a) progesterone may decrease drug reward, craving, and smoking behavior, and (b) estradiol may enhance drug reward and smoking behavior. A modest majority of treatment research examining the relationship between menstrual cycle phase and outcomes suggests that the luteal menstrual phase, with its uniquely higher progesterone levels, is associated with better cessation outcomes. However, no studies to date have examined the effects of naturally occurring variation in progesterone and estradiol levels on medication-assisted smoking cessation. The present study sought to fill this notable gap in the treatment literature. Methods: Weekly plasma progesterone and estradiol levels were obtained from nicotine-dependent female smokers enrolled in a 4-week cessation trial. Participants (N = 108) were randomized to receive a 4-week course of either varenicline (VAR) tablets and placebo patches or placebo tablets and nicotine patches. Plasma samples were obtained 1 week before their cessation attempt and weekly during medication administration. Abstinence was assessed weekly. Results: Weekly hormone data replicated commonly observed menstrual cycle patterns of progesterone and estradiol levels. Importantly, increases in progesterone level were associated with a 23% increase in the odds for being abstinent within each week of treatment. This effect was driven primarily by nicotine patch-treated versus VAR-treated females. Conclusions: This study was the first to identify an association between progesterone level (increasing) and abstinence outcomes in free-cycling women smokers who participated in a medicationbased treatment. Furthermore, the potential benefits of progesterone may vary across different pharmacotherapies. Implications of these findings for smoking cessation intervention are discussed.

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Ovarian hormones and propensity to drug relapse: A review

Cited by 87 publications

References 99 publications

CRF2 Receptor Deficiency Eliminates the Long-Lasting Vulnerability of Motivational States Induced by Opiate Withdrawal

CRF2 Receptor Deficiency Eliminates the Long-Lasting Vulnerability of Motivational States Induced by Opiate Withdrawal

Sex Differences in Animal Models: Focus on Addiction

Increasing Progesterone Levels Are Associated With Smoking Abstinence Among Free-Cycling Women Smokers Who Receive Brief Pharmacotherapy

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