Ovarian Hormones and Reward Processes in Palatable Food Intake and Binge Eating

Ma, Ruofan; Mikhail, Megan E.; Culbert, Kristen M.; Johnson, Alex W.; Sisk, Cheryl L.; Klump, Kelly L.

doi:10.1152/physiol.00013.2019

Cited by 32 publications

(22 citation statements)

References 117 publications

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“…These findings highlight predisposition to negative moods as a potentially important transdiagnostic contributor to MDD/ANX and disordered eating. Nonetheless, negative emotionality did not fully account for associations (particularly with ED diagnoses), suggesting that additional shared mechanisms likely exist (e.g., reward‐based processes that may contribute to MDD/ED comorbidity; Clark & Watson, 1991; Ma et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Increased rates of eating disorders and their symptoms in women with major depressive disorder and anxiety disorders

Garcia

Mikhail

Keel

et al. 2020

Intl J Eating Disorders

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Background: Individuals with eating disorders (EDs) have increased rates of major depressive disorder (MDD) and anxiety disorders. Yet, few studies have investigated rates of EDs and their symptoms in individuals presenting with MDD/anxiety disorders. Identifying potential disordered eating in people with MDD/anxiety disorders is important because even subclinical disordered eating is associated with reduced quality of life, and undiagnosed eating pathology may hinder treatment progress for both MDD/anxiety disorders and comorbid EDs. Method: We compared rates of EDs (anorexia nervosa, bulimia nervosa, binge-eating disorder, and other specified feeding and eating disorders) and their symptoms in 130 women with, and 405 women without, lifetime MDD or an anxiety disorder (generalized anxiety disorder, obsessive-compulsive disorder, social phobia, specific phobia, panic disorder, agoraphobia, or post-traumatic stress disorder) recruited from the population-based Michigan State University Twin Registry. Lifetime ED and MDD/anxiety diagnoses, and lifetime clinically significant disordered eating behaviors (e.g., binge eating, excessive exercise) were assessed using the Structured Clinical Interview for DSM-IV (SCID). Results: Among participants with lifetime MDD or any anxiety disorder, 13% met criteria for a lifetime ED and 39% reported engaging in at least one lifetime clinically significant disordered eating behavior (e.g., binge eating) on the SCID. In contrast, only 3% of participants without a history of MDD/an anxiety disorder met criteria for a lifetime ED, and only 11% reported lifetime clinically significant disordered eating behavior. Discussion: Our findings suggest that women with MDD and anxiety disorders have elevated rates of EDs, and it is therefore imperative to screen for disordered eating in these populations.

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Section: Discussionmentioning

confidence: 99%

Increased rates of eating disorders and their symptoms in women with major depressive disorder and anxiety disorders

Garcia

Mikhail

Keel

et al. 2020

Intl J Eating Disorders

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“…If the relationship between lower PED and binge eating is primarily driven by hedonic processes (i.e., desire for positive affect), this may help explain why low PED was less consistently associated with eating in response to negative emotions (i.e., emotional eating). Importantly, while binge eating is often associated with negative affect, disruptions in reward processes have also been implicated (e.g., Avena & Bocarsly, ; Ma et al, in press).…”

Section: Discussionmentioning

confidence: 99%

Low emotion differentiation: An affective correlate of binge eating?

Mikhail

Keel

Burt

et al. 2019

Intl J Eating Disorders

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Background Low emotion differentiation (the tendency to experience vague affective states rather than discrete emotions) is associated with psychopathology marked by emotion regulation deficits and impulsive/maladaptive behavior. However, research examining associations between emotion differentiation and dysregulated eating is nascent and has yet to incorporate measures of clinically significant binge eating. Different measures of emotion differentiation have also been used, impeding cross‐study comparisons. We therefore examined associations between several emotion differentiation measures and binge eating‐related phenotypes across a spectrum of severity. Methods Women (N = 482) from the Michigan State University Twin Registry completed the Positive and Negative Affect Schedule (PANAS) daily for 45 consecutive days. Three measures of negative/positive emotion differentiation (NED/PED) were created using the intraclass correlation coefficient (ICC), average interitem correlation, and average daily variance between negative/positive emotion ratings on the PANAS. Associations between NED/PED measures and emotional eating (EE) and a history of binge eating episodes (BEs) were then examined, controlling for affect intensity and BMI. Results Lower PED was associated with greater odds of BEs across the ICC and average interitem correlation measures, and more EE on the daily variance measure. Findings involving NED were less consistent; lower NED was associated with greater EE and greater odds of BEs using the daily variance measure only. Conclusion Low PED is associated with clinically significant binge eating, and some aspects of NED may also be relevant for binge eating‐related phenotypes. Further research examining the constructs captured by different emotion differentiation measures and their relevance to binge eating is needed.

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“…Similarly to N/OFQ-NOP system, considerable evidence suggested sex differences in other orexigenic signaling mechanisms implicated in binge eating, such those depending on the relaxin-family peptide-3 [244,245] and orexin-1 receptors [246][247][248]. This is not surprising considering that sexual dimorphism has been described in binge eating behavior both in humans [249][250][251] and animals [252][253][254][255][256]. In light of the complex role of N/OFQ in feeding regulation, and based on the current knowledge, it is difficult to provide an unambiguous interpretation of the effect of NOP on binge eating.…”

Section: Role Of the N/ofq-nop System In The Regulation Of Feeding And Food-related Disordersmentioning

confidence: 99%

Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders

Ubaldi

Cannella

Borruto

et al. 2021

IJMS

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Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence homology with the precursors of other opioid neuropeptides but it does not activate either MOP, KOP or DOP receptors. Furthermore, opioid neuropeptides do not activate the NOP receptor. Generally, activation of N/OFQ system exerts anti-opioids effects, for instance toward opioid-induced reward and analgesia. The NOP receptor is widely expressed throughout the brain, whereas N/OFQ localization is confined to brain nuclei that are involved in stress response such as amygdala, BNST and hypothalamus. Decades of studies have delineated the biological role of this system demonstrating its involvement in significant physiological processes such as pain, learning and memory, anxiety, depression, feeding, drug and alcohol dependence. This review discusses the role of this peptidergic system in the modulation of stress and stress-associated psychiatric disorders in particular drug addiction, mood, anxiety and food-related associated-disorders. Emerging preclinical evidence suggests that both NOP agonists and antagonists may represent a effective therapeutic approaches for substances use disorder. Moreover, the current literature suggests that NOP antagonists can be useful to treat depression and feeding-related diseases, such as obesity and binge eating behavior, whereas the activation of NOP receptor by agonists could be a promising tool for anxiety.

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Ovarian Hormones and Reward Processes in Palatable Food Intake and Binge Eating

Cited by 32 publications

References 117 publications

Increased rates of eating disorders and their symptoms in women with major depressive disorder and anxiety disorders

Increased rates of eating disorders and their symptoms in women with major depressive disorder and anxiety disorders

Low emotion differentiation: An affective correlate of binge eating?

Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders

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