Ovarian hormones modulate ‘compulsive’ lever-pressing in female rats

Flaisher-Grinberg, Shlomit; Albelda, Noa; Gitter, Liron; Weltman, Keren; Arad, Michal; Joel, Daphna

doi:10.1016/j.yhbeh.2008.10.002

Cited by 37 publications

(27 citation statements)

References 67 publications

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“…This is in line with evidence implicating the modulation of compulsive behavior by ovarian hormones in three animal models of OCD: 8-OHDPAT-induced decreased alternation in rats, marble burying in mice and rats and signal attenuation in rats. Those studies revealed that an estradiol increase exerts an anti-compulsive effect and that the withdrawal from repeated estradiol administration has an opposite effect, namely to increase compulsive responding (Albelda and Joel, 2012, in press;Flaisher-Grinberg et al, 2009;Hill et al, 2007). In mice, females were one and a half times more likely to barber than males and breeding mice were approximately five and a half times more likely to barber than nonbreeders (Garner et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Adrenal activity and anxiety-like behavior in fur-chewing chinchillas (Chinchilla lanigera)

Ponzio

Monfort

Busso

et al. 2012

Hormones and Behavior

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Section: Discussionmentioning

confidence: 99%

Adrenal activity and anxiety-like behavior in fur-chewing chinchillas (Chinchilla lanigera)

Ponzio

Monfort

Busso

et al. 2012

Hormones and Behavior

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“…The model displays high face, predictive and construct validity 20,21 , and has been extensively used to study the neural substrates of this behavior 39,[43][44][45]48 , its response to pharmacological manipulations 38,39,43,47,53,54 and to deep brain stimulation 40,46,50 and its modulation by ovarian hormones 51 . Thus, this model is a useful animal model for the study of OCD.…”

Section: Discussionmentioning

confidence: 99%

“…An important aspect of the signal attenuation model which has been mentioned above is the fact that compulsive lever-pressing is modulated by fluctuations in ovarian hormone levels along the rat estrous cycle 51 . This aspect is important for researchers interested in studying the mechanisms by which female gonadal hormones affect compulsive behaviors.…”

Section: Discussionmentioning

confidence: 99%

“…This aspect is important for researchers interested in studying the mechanisms by which female gonadal hormones affect compulsive behaviors. Although the effects of male gonadal hormones on compulsive lever-pressing have not been tested, these or other factors are affecting male performance in the model, as the variability of the different response measures in the model is similar in male and female rats 51 . Therefore, researchers, who do not aim to study the role of gonadal hormones, may use both male and female rats without measuring the level of these hormones.…”

Section: Discussionmentioning

confidence: 99%

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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Goltseker

Yankelevitch-Yahav

Albelda

et al. 2015

JoVE

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In the signal attenuation rat model of obsessive-compulsive disorder (OCD), lever-pressing for food is followed by the presentation of a compound stimulus which serves as a feedback cue. This feedback is later attenuated by repeated presentations of the stimulus without food (without the rat emitting the lever-press response). In the next stage, lever-pressing is assessed under extinction conditions (i.e., no food is delivered). At this stage rats display two types of lever-presses, those that are followed by an attempt to collect a reward, and those that are not. The latter are the measure of compulsive-like behavior in the model. A control procedure in which rats do not experience the attenuation of the feedback cue serves to distinguish between the effects of signal attenuation and of extinction. The signal attenuation model is a highly validated model of OCD and differentiates between compulsive-like behaviors and behaviors that are repetitive but not compulsive. In addition the measures collected during the procedure eliminate alternative explanations for differences between the groups being tested, and are quantitative, unbiased and unaffected by inter-experimenter variability. The major disadvantages of this model are the costly equipment, the fact that it requires some technical know-how and the fact that it is time-consuming compared to other models of OCD (11 days). The model may be used for detecting the anti-or pro-compulsive effects of pharmacological and non-pharmacological manipulations and for studying the neural substrate of compulsive behavior.

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“…It has been reported that OCD has an earlier onset and a more insidious course in males whereas, in females, it mostly has an episodic course and an acute onset that is more related to life events (Bogetto et al, 1999). Also, alterations in sex hormones may affect the course of OCD (Flaisher-Grinberg et al, 2009). The ratio of the index finger (2D) to the ring finger (4D), (2D:4D), differs between genders.…”

Section: Introductionmentioning

confidence: 99%

THE RATIO OF SECOND FINGER TO FOURTH FINGER IN CHILDREN AND ADOLESCENTS WITH OBSESSIVE COMPULSIVE DISORDER. La proporción entre los dedos índice y anular en los niños y adolescentes que tienen trastorno obsesivo-compulsivo

Taner

GÖZİL

İşeri

et al. 2016

Rev Arg de Anat Clin

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Objectives: The ratio of the index finger (2D) to the ring finger (4D) is different in males and females. This ratio (2D:4D) has been investigated in a variety of diseases, including autism, schizophrenia, attention deficit hyperactivity disorder, and anxiety disorders. The aim of this study was to investigate the 2D:4D ratio in children and adolescents with obsessive compulsive disorder and to detect any differences in that ratio between participants with obsessive compulsive disorder and a healthy control Material-Methods: The study included 30 children and adolescents diagnosed with obsessive compulsive disorder between ages 7-17 and 90 age-sex matched controls. After the psychiatric evaluations; finger lenghts were measured with a digital compass. Main results: Girls with obsessive compulsive disorder had greater 2D:4D ratios in their right and left hands than the control group. Although there was no statistically significant difference, the 2D:4D ratio in the right hand was greater in the obsessive compulsive disorder group than in the control group. Conclusion: With relation to obsessive compulsive disorder, some differences were detected in 2D:4D ratios of patients with obsessive compulsive disorder and control groups but there were no statistically significant results except for that of girls with obsessive compulsive disorder. Further studies are needed to fully understand the relationship between obsessive compulsive disorder and the 2D:4D ratio. Objetivos: La proporción entre los dedos índice y anular es diferente en las mujeres y en los hombres. Esta proporción ha sido estudiada en varias enfermedades como el trastorno de ansiedad, el trastorno de la concentración y la hiperactividad. El objetivo de este estudio era investigar la proporción entre los dedos de índice y anular en los niños y adolescentes que tienen trastorno obsesivo-compulsivo y determinar si existía alguna diferencia entre los participantes con trastorno obsesivo-compulsivo y los del grupo sano. Material y métodos: En el estudio fueron incluidos 30 niños y adolescentes que tenían entre 7 y 17 años de edad con trastorno obsesivo-compulsivo y 90 individuos sanos de igual edad y sexo como el grupo control. Después de las evaluaciones psiquiátricas, la longitud de los dedos fue medida con calibre digital. Resultados: Las niñas y adolescentes con trastorno obsesivo-compulsivo tenían una proporción mayor entre los dedos índice y anular en las manos derechas e izquierdas que el grupo control. Aunque no había una diferencia estadísticamente significativa, la proporción entre los dedos índice y anular en la mano derecha era más grande en el grupo de trastorno obsesivo-compulsivo que el grupo control. Conclusiones: Algunas diferencias fueron detectadas en la proporción entre los dedos índice y anular en los pacientes con trastorno obsesivo-compulsivo y los del grupo control, pero no había resultados estadísticamente significativos excepto las niñas y adolescentes con trastorno obsesivo-compulsivo. Se requieren más estudios para entender completamente la relación entre el trastorno obsesivo-compulsivo y la proporción entre los dedos índice y anular.

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Ovarian hormones modulate ‘compulsive’ lever-pressing in female rats

Cited by 37 publications

References 67 publications

Adrenal activity and anxiety-like behavior in fur-chewing chinchillas (Chinchilla lanigera)

Adrenal activity and anxiety-like behavior in fur-chewing chinchillas (Chinchilla lanigera)

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

THE RATIO OF SECOND FINGER TO FOURTH FINGER IN CHILDREN AND ADOLESCENTS WITH OBSESSIVE COMPULSIVE DISORDER. La proporción entre los dedos índice y anular en los niños y adolescentes que tienen trastorno obsesivo-compulsivo

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