Ovarian hyperandrogenism in adolescents and young women with type I diabetes is primarily related to birth weight and body mass index

Bizzarri, Carla; Benevento, Danila; Ravà, Lucilla; Patera, Ippolita Patrizia; Schiaffini, Riccardo; Ciampalini, Paolo; Giannone, Germana; Cappa, Marco

doi:10.1016/j.fertnstert.2011.09.023

Cited by 19 publications

(11 citation statements)

References 44 publications

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“…Some of them have been cited above according to all the consensus criteria (3,4,5). Notably, all these diseases are characterized by a specific (58,59,60,61,62). In accordance with the reasoning followed in this paper, it is important to point out that almost all these diseases can be treated, although not all can be completely cured, because of their genetic background and/or the incomplete clarification of pathophysiological mechanisms.…”

Section: Pcos Secondary To Other Endocrinopathies and Other Disordersmentioning

confidence: 61%

MANAGEMENT OF ENDOCRINE DISEASE: Secondary polycystic ovary syndrome: theoretical and practical aspects

Pasquali

Diamanti-Kandarakis

Gambineri

2016

European Journal of Endocrinology

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PCOS is a clinical heterogeneous entity of female androgen excess diagnosed by exclusion of other disorders responsible for androgen excess. The concept of secondary PCOS implies that there is a primary well-defined cause leading to the PCOS phenotype with underlying androgen overproduction, regardless of the origin. In these cases, we presume the term of 'secondary PCOS' could be used. In all these conditions, the potential complete recovery of the hyperandrogenemic state as well as the remission of the PCOS phenotype should follow the removal of the cause. If accepted, these concepts could help clinicians to perform in-depth investigations of the potential factors or disorders responsible for the development of these specific forms of secondary PCOS. Additionally, this could contribute to develop further research on factors and mechanisms involved in the development of the classic and the nonclassic PCOS phenotypes. Invited author's profileRenato Pasquali is full professor of Endocrinology & Metabolism and Director of the division of Endocrinology of the S.Orsola-Malpighi Hospital, Bologna, Italy. He also heads the School of Specialization in Endocrinology and Metabolism, University Alma Mater Studiorum of Bologna, Italy. He is a member of numerous national and international scientific societies and serves on the editorial boards of international journals. His scientific interests relate to (i) the pathophysiology and treatment of the polycystic ovary syndrome; (ii) the endocrinology of obesity (sex hormones, the hypothalamic-pituitary-adrenal axis, and the endocannabinoid system).

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Section: Pcos Secondary To Other Endocrinopathies and Other Disordersmentioning

confidence: 61%

MANAGEMENT OF ENDOCRINE DISEASE: Secondary polycystic ovary syndrome: theoretical and practical aspects

Pasquali

Diamanti-Kandarakis

Gambineri

2016

European Journal of Endocrinology

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“…2). The smallest prevalence (7%) was found in Italian adolescents (13), and the largest (41%) was reported in Chilean adolescent and adult women (10) using the ESHRE/ASRM definition of PCOS (Table 2). In studies specifically reporting the prevalence according to different definitions of the syndrome (10,15), the largest prevalences were found when using the ESHRE/ASRM definition, followed by AE-PCOS and NIH criteria ( Table 2).…”

Section: Meta-analysis Of Prevalence Of Pcos and Related Traitsmentioning

confidence: 99%

“…Six addressed fertility issues and eighteen addressed menstrual cycle characteristics of type 1 diabetes but were unrelated to androgen excess ( Fig. 1 and Supplementary Data), leaving seventeen original articles dealing with androgen excess (8)(9)(10)(11)(12)(13)(14)(15)(16)(24)(25)(26)(27)(28)(29)(30)(31). Only 9 of these 17 articles contained data about the prevalence of PCOS and related traits (8,(10)(11)(12)(13)(14)(15)(16)28) and were included in the meta-analyses.…”

Section: Data Synthesis and Analysismentioning

confidence: 99%

“…Women under intensive insulin treatment had a significantly higher prevalence of PCOM and PCOS compared with those under conventional two-dose insulin treatment (10). Three studies included patients on intensive treatment with multiple dose injection or continuous subcutaneous insulin infusion, and no differences were observed in the appearance of PCOS or hyperandrogenic symptoms (13,15,16).…”

Section: Differences In Women With Type 1 Diabetes Depending On the Pmentioning

confidence: 99%

“…Of note, even though this association was confirmed by all of the studies that addressed the issue thereafter (10)(11)(12)(13)(14)(15)(16), with prevalences of PCOS as high as 40% in some series (10,16), this syndrome is seldom diagnosed and treated in women with type 1 diabetes.…”

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confidence: 93%

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Type 1 Diabetes and Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Escobar-Morreale

Roldán-Martín

2016

Diabetes Care

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A few small studies have reported increased prevalences of polycystic ovary syndrome (PCOS) and symptoms of androgen excess in women with type 1 diabetes. PURPOSEWe performed a systematic review and meta-analysis of studies evaluating androgen excess symptoms and PCOS in women with type 1 diabetes. DATA SOURCESThe Entrez-PubMed and Scopus electronic databases were used. STUDY SELECTIONWe selected studies addressing androgen excess signs, symptoms, and disorders in girls, adolescents, and adult women with type 1 diabetes. DATA EXTRACTIONThe main outcome measures were prevalences of PCOS, hyperandrogenemia, hirsutism, menstrual dysfunction, and polycystic ovarian morphology (PCOM). DATA SYNTHESISNine primary studies involving 475 adolescent or adult women with type 1 diabetes were included. The prevalences of PCOS and associated traits in women with type 1 diabetes were 24% (95% CI 15-34) for PCOS, 25% (95% CI 17-33) for hyperandrogenemia, 25% (95% CI 16-36) for hirsutism, 24% (95% CI 17-32) for menstrual dysfunction, and 33% (95% CI 24-44) for PCOM. These figures are considerably higher than those reported earlier in the general population without diabetes. LIMITATIONSThe data collected in the original studies were heterogeneous in age, race, ethnicity, and criteria used for the diagnosis of PCOS; yet, we used a quality-effects model in the meta-analyses to overcome this limitation. CONCLUSIONSPCOS and its related traits are frequent findings in women with type 1 diabetes. PCOS may contribute to the subfertility of these women by a mechanism that does not directly depend on glycemic/metabolic control among other negative consequences for their health. Hence, screening for PCOS and androgen excess should be included in current guidelines for the management of type 1 diabetes in women.

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Ovarian functions and polycystic ovary syndrome in adult women with type 1 diabetes mellitus in a Turkish population

Urhan

Elbüken

Hacıoğlu

et al. 2022

J Endocrinol Invest

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Ovarian hyperandrogenism in adolescents and young women with type I diabetes is primarily related to birth weight and body mass index

Cited by 19 publications

References 44 publications

MANAGEMENT OF ENDOCRINE DISEASE: Secondary polycystic ovary syndrome: theoretical and practical aspects

MANAGEMENT OF ENDOCRINE DISEASE: Secondary polycystic ovary syndrome: theoretical and practical aspects

Type 1 Diabetes and Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Ovarian functions and polycystic ovary syndrome in adult women with type 1 diabetes mellitus in a Turkish population

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