Ovarian hyperstimulation syndrome

McElhinney, Bernie; McClure, Neil

doi:10.1053/beog.1999.0066

Cited by 18 publications

(15 citation statements)

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“…It is also suggested that a significant and consistent relationship exists between PCO and ovarian hyperstimulation syndrome (OHSS) [Tummon et al 2005]. OHSS is characterized by marked ovarian enlargement and increased capillary permeability and occasionally occurs after gonadotrophin therapies [McElhinney and Mcclure 2000].…”

Section: Introductionmentioning

confidence: 99%

“…Interleukin-6 (IL-6) is now recognized for its role in increased liver synthesis of acute phase proteins such as C-reactive proteins (CRPs), and increased vascular permeability of the ovarian and peritoneal vessels in the acute phase in the inflammatory reactions which can be linked to OHSS [McElhinney and Mcclure, 2000]. In addition, many studies have indicated that IL-6, as one of the pro-inflammatory cytokines, may participate in the development of insulin resistance and type 2 diabetes [Spranger et al 2003], and thus suggest a possible link to metabolic alterations in PCOS.…”

Section: Introductionmentioning

confidence: 99%

“…We believe that the correlation between PCOS and serum IL-6 needs further confirmation. In addition, IL-6 is linked to OHSS [McElhinney and Mcclure 2000], and its levels in follicular fluid, not in serum, were considered as a predictive marker of early OHSS by Artini et al [2002]. In contrast, serum IL-6 concentrations were found to be statistically greater in patients who developed or had risk for OHSS when compared with controls.…”

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confidence: 99%

“…It is desired that any predictive marker for early OHSS be detected. At present, some inflammatory cytokines and growth factors are the possible pathogenetic forerunners under investigation, but none are definitive or capable of predicting early OHSS [McElhinney and Mcclure 2000].…”

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confidence: 99%

“…In addition, it has been shown to be associated with poorer oocyte and embryo quality and lower pregnancy rates [Nugent et al 2000]. hCG is considered one of the risk factors of OHSS [McElhinney and Mcclure 2000]. Therefore, ovarian responses can be associated with the risk of OHSS.…”

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confidence: 99%

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Response of IGF and IL-6 to Ovarian Stimulation in PCOS and Normal Women

Liang

et al. 2009

Systems Biology in Reproductive Medicine

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The objective of the present study was to investigate the response patterns of insulin-like growth factors (IGFs) and interleukin-6 (IL-6) to ovarian stimulation within 24 h in patients with polycystic ovary syndrome (PCOS) in comparison with normally ovulating women. This controlled prospective clinical study involved 60 women who attended an infertility clinic. For the induction of the ovarian stimulation, fifty-two patients with PCOS and eight control cases were injected with human menopause gonadotropin (hMG) and human chorionic gonadotropin (hCG) during the early follicular phase of the natural or induced menstrual cycle. The blood was sampled before (0 h) and 6, 12, 18, and 24 h after the stimulation. Serum levels of estradiol (E2), IGF-I, IGF-II and IL-6 were measured by radioimmunoassay. A significant decrease in serum IGF-II at 12 h was observed after a mixture of hMG and hCG was administered in patients with polycystic ovaries (PCO) including the typical PCOS group and the PCO þ OA group (accumulated p < 0.05), while normal women presented a slight decrease (accumulated p < 0.1) 18 h after the stimulation. Moreover, all the groups had similar serum levels of IL-6 and IGF-I at all time points. An increase in serum E2 occurred coincident with a decrease in IGF-II in all the groups except the ovarian hyperandrogenism patients (HA þ OA group). Serum IGF-II levels, which appeared to be negatively correlated with elevated E2, statistically decreased in PCO patients early after hMG and hCG administration when monitored for 24 h, while no such changes were observed in IGF-I and IL-6.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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