Ovarian immature teratoma: Treatment and outcome in a single institutional cohort

Vicus, Danielle; Beiner, Mario; Clarke, Blaise A.; Klachook, S.; Le, Lisa W.; Laframboise, Stéphane; Mackay, Helen

doi:10.1016/j.ygyno.2011.06.037

Cited by 37 publications

(42 citation statements)

References 18 publications

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“…Although there are several case series on immature teratomas, our case series includes a focus on successfully treated recurrences as well. In this study, the mean age of occurrence was 21 years which is similar to other studies [2,5,6]. Pain was the commonest presenting symptom and abdominal mass was present in 56%.…”

Section: Commentssupporting

confidence: 89%

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Immature teratoma of ovary – outcome following primary and secondary surgery: study of a single institution cohort

Reddihalli

Subbian

Umadevi

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Commentssupporting

confidence: 89%

“…In our study, 20.8% (n = 5) of patients had advanced stage III disease compared to only 5% (2 out of 34) in a Canadian trial [5] and 30% seen in an Indian trial by Deodhar et al [6]. Survival rate in this group was 80% after an average follow-up of 37 months (range 18-54 months).…”

Section: Commentscontrasting

confidence: 44%

Immature teratoma of ovary – outcome following primary and secondary surgery: study of a single institution cohort

Reddihalli

Subbian

Umadevi

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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“…However, the mainstay of treatment is surgery consisting of a complete tumor excision or radical hysterectomy with or without pelvic and para-aortic lymphadenectomy [2]. Also, the use of preoperative or postoperative chemotherapy can be extrapolated from ovarian malignant germ cells tumors guidelines [10]. In this case, three or four courses of BEP regimen are recommended [11].…”

Section: Discussionmentioning

confidence: 99%

Primary Immature Teratoma of the Uterus Relapsing as Malignant Neuroepithelioma: Case Report and Review of the Literature

Mohtaram

Kharmoum

Aaribi

et al. 2013

Case Reports in Oncological Medicine

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Background. Although some mature cases of teratomas have recently been described in the cervix, they are not commonly found in the uterus, especially in immature forms. An immature uterine teratoma relapsing after surgery as malignant neuroepithelioma has never been reported in the literature. Case Presentation. We describe a case of immature teratoma which occurred primarily in the uterus in a 56-year-old female. Treatment consisted of total simple hysterectomy. Three months after surgery, the patient relapsed with voluminous pelvic mass and was treated with bleomycin, etoposide, and cisplatin-containing chemotherapy regimen. Conclusion. In this report and according to the pertinent literature, clinical and pathological features and management of uterine immature teratomas are discussed. The mainstay of treatment is surgery. The prognosis of this unusual disease remains uncertain.

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“…However, the post-operative management of stage I grade 2-3 immature teratoma is still debated and a policy of surveillance only can be taken into consideration, with salvage chemotherapy reserved for cases of recurrence with excellent chances of therapeutic success [22,23]. Radiotherapy was the standard postoperative treatment for metastatic dysgerminoma for several decades [24].…”

Section: Introductionmentioning

confidence: 99%

Menstrual function and childbearing potential after fertility-sparing surgery and platinum-based chemotherapy for malignant ovarian germ cell tumours

Gadducci

Lanfredini

Tana

2014

Gynecological Endocrinology

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Malignant ovarian germ cell tumours (MOGCT) account for 5% of all ovarian malignancies. Their elevated chemosensitivity, the frequent unilaterality and the young age of patients have strongly supported the conservative surgery as the standard approach, often followed by adjuvant platinum-based chemotherapy. The risk for recurrence is not affected by the performance of conservative versus radical surgery. During chemotherapy 50% of patients become amenorrhoeic but more than 95% of them resume normal menses after treatment completion. Literature has reported several healthy babies born after fertility-sparing surgery with or without chemotherapy for MOGCT. The incidence of miscarriages is in the normal range, whereas malformation rate is slightly higher compared to general population, without any difference between chemotherapy-treated and -untreated patients. Therefore, young women with MOGCT must be reassured of their excellent chances of survival and fertility preservation following conservative surgery and adjuvant platinum-based chemotherapy.

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Ovarian immature teratoma: Treatment and outcome in a single institutional cohort

Cited by 37 publications

References 18 publications

Immature teratoma of ovary – outcome following primary and secondary surgery: study of a single institution cohort

Immature teratoma of ovary – outcome following primary and secondary surgery: study of a single institution cohort

Primary Immature Teratoma of the Uterus Relapsing as Malignant Neuroepithelioma: Case Report and Review of the Literature

Menstrual function and childbearing potential after fertility-sparing surgery and platinum-based chemotherapy for malignant ovarian germ cell tumours

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