Ovarian-independent fluctuations of estradiol receptor levels in mammalian tissues

Hughes, Alun; Jacobson, Herbert I.; Wagner, R. K.; Jungblut, P. W.

doi:10.1016/0303-7207(76)90020-4

Cited by 63 publications

(13 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to this cyclical variance in menstrual hormones, breast cancer ER and PgR expression has been demonstrated to exhibit circannual rhythmicity [31]. ER and PgR expression reaches a nadir during the spring season [32–36], which explains the localized restriction of tumor growth seen during spring in a previous study [30]. Because 50%–80% of invasive breast cancers are hormone-responsive [37], the complex interactions between rhythmic hormone and hormone receptor levels may have concealed any seasonal survival patterns caused by vitamin D 3 production.…”

Section: Discussionmentioning

confidence: 99%

Seasonality pattern of breast, colorectal, and prostate cancer is dependent on latitude

Gabriel

Bhatnagar

et al. 2014

Med Sci Monit

View full text Add to dashboard Cite

BackgroundThe season of diagnosis of several forms of cancer has been observed to impact survival, supporting the hypothesis that vitamin D3 has a protective role in cancer survival. All previous studies demonstrating this seasonality were performed in European populations residing at latitudes upwards of 50°N. This study investigated whether seasonality of prognosis persists in populations residing in the lower latitudes of the contiguous United States (Latitude 21°N to 48°N).Material/MethodsThe 5-year survival data of 19 204 female breast cancer, 6740 colorectal cancer, and 1644 prostate cancer cases was analyzed.ResultsFemale breast cancer patients exhibited improved survival when diagnosed in the summer as compared to the winter at all latitudes (Hazard Ratio [HR]: 0.940, 95%; Confidence Interval [CI]: 0.938 to 0.941, P=0.002). Colorectal cancer and prostate cancer also exhibited a similar seasonal pattern (HR: 0.978, 95% CI: 0.975 to 0.980, P=0.008 and HR: 0.935, 95%, CI 0.929 to 0.943, P=0.006), respectively, when the analysis was restricted to northern regions.ConclusionsThese observations contribute to the mounting evidence that vitamin D3 may affect the progression of cancer. Data also suggest that vitamin D3 status at the onset of treatment may synergistically improve the prognosis of several cancer types.

show abstract

Section: Discussionmentioning

confidence: 99%

Seasonality pattern of breast, colorectal, and prostate cancer is dependent on latitude

Gabriel

Bhatnagar

et al. 2014

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…By comparison, benign breast disease has not been shown to have a seasonal variation [6]. Other effects of season on breast cancer have also been reported [4,5,[7][8][9][10].…”

Section: Introductionmentioning

confidence: 93%

Association between season of first detection of breast cancer and disease progression

Mason¹,

Holdaway²,

Skinner³

et al. 1987

Breast Cancer Res Tr

View full text Add to dashboard Cite

The season of recurrence of tumour was investigated by follow-up of 1324 patients with breast cancer and compared with the season of initial tumour detection. Unlike primary tumours, where an increased incidence of detection has previously been observed in late spring and early summer, there was no significant seasonal variation in the time of recurrence. However, women with oestrogen receptor positive or progesterone receptor negative primary tumours recurred significantly more frequently in the same season that their primary cancer was initially detected. Overall there was an increased frequency of recurrence one year from diagnosis. Women less than age 50 who initially found their tumour in winter or autumn had a significantly shorter disease-free interval before recurrence than those first detecting their tumour in summer or spring. This relationship was independent of nodal status and tumour size. Tumours initially detected in winter or autumn thus appeared to follow a more aggressive growth profile. This study indicates that the season of first detection of a breast cancer relates significantly to aspects of the future biologic behaviour of the tumour.

show abstract

“…This can possibly be explained by the fact that these experiments were performed during different seasons. Hughes, Jacobson, Wagner & Jungblut (1976) observed such circannual variations of uterine oestrogen receptors.…”

Section: Resultsmentioning

confidence: 93%

Effects of Endocrine Manipulations on Oestrogen Binding in Cytosols From Rat Skeletal and Perineal Muscles

Dionne¹,

Dubé²,

Frenette³

et al. 1980

Journal of Endocrinology

View full text Add to dashboard Cite

Hormonal regulation of cytosolic oestradiol-binding sites in the levator ani bulbocavernosus (LA/BC) muscles of male rats and in thigh muscles from male and female rats was investigated. Twenty-four hours after gonadectomy and/or adrenalectomy, the number of unoccupied oestradiol-binding sites was significantly increased in cytosols prepared from LA/BC muscles while these treatments had no effect on thigh muscles from male rats. Only a combination of both treatments led to a significant increase of oestradiol-binding sites in cytosols prepared from the thigh muscles of female rats when compared with those of intact rats at dioestrus. The number of oestradiol-binding sites in the thigh muscles of female rats was found to vary during the oestrous cycle with values significantly lower at pro-oestrus than at dioestrus. The increase in oestradiol-binding sites observed in cytosols prepared from muscles of adrenalectomized or gonadectomized plus adrenalectomized rats was prevented by an injection of corticosterone (3 mg, s.c.) at the time of surgery. Twenty-one days after gonad and/or adrenal ablation, the mean concentration of oestradiol-binding sites in the three tissues under study was higher than in these tissues from intact rats, and in some groups the levels of oestradiol-binding sites were significantly higher than they had been 24 h after the same surgical treatments. Muscles from male rats hypophysectomized for 28 days possessed levels of oestradiol-binding sites equivalent to male rats deprived of steroid hormones for 21 days. Dexamethasone treatment ofmale rats (100 \g=m\g/day for 14 days) led to a progressive decrease of oestradiol-binding sites of LA/BC and thigh muscles. This study has shown that adrenal and gonadal hormones exert both short-and long-acting repressive effects on the oestradiol-binding capacity of rat muscles.

show abstract

Ovarian-independent fluctuations of estradiol receptor levels in mammalian tissues

Cited by 63 publications

References 4 publications

Seasonality pattern of breast, colorectal, and prostate cancer is dependent on latitude

Seasonality pattern of breast, colorectal, and prostate cancer is dependent on latitude

Association between season of first detection of breast cancer and disease progression

Effects of Endocrine Manipulations on Oestrogen Binding in Cytosols From Rat Skeletal and Perineal Muscles

Contact Info

Product

Resources

About