Ovarian interstitial cell tumour in a Mongolian gerbil (Meriones unguiculatus)

Kubiak, Marie; Jayson, Stephanie; Denk, Daniela

doi:10.1136/vetreccr-2015-000182

Cited by 5 publications

(8 citation statements)

References 24 publications

(44 reference statements)

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“…Dies gibt Anlass, auch die Kleinsten unter unseren Patienten motiviert zu versorgen, da die Alternativen nur das Versterben an der Erkrankung oder die Euthanasie sind. Die Palpation des Abdomens im Rahmen der klinischen Untersuchung lässt in den meisten Fällen eine Verdachtsdiagnose zu 4 , 5 , 6 . Diese muss durch Röntgen und Ultraschall abgesichert werden 4 , 6 .…”

Section: Abwägung Von Nutzen Und Risiken Der Operationunclassified

“…Den Hauptanteil der Neoplasien stellten damals Granulosazelltumore , gefolgt von Thekazelltumoren, Leiomyoma und Adenokarzinomen 1 , 2 , 3 . Aktuellere Studien und Fallberichte bestätigen diese Forschungen 4 , 5 , 6 , 7 , 8 .…”

Section: Introductionunclassified

“…Auch in der vorliegenden Fallserie bestätigte sich die Erkenntnis aus den vorangegangenen Studien, dass Ovarialtumore (wie z. B. Granulosazelltumoren) mit hoher Inzidenz auftreten 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 .…”

Section: Introductionunclassified

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Chirurgische Therapie von Ovarialtumoren bei Mongolischen Rennmäusen

Fischbach-Ulfik¹,

Meißner²,

Hungerkamp³

et al. 2022

kleintier konkret

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Section: Abwägung Von Nutzen Und Risiken Der Operationunclassified

Section: Introductionunclassified

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Chirurgische Therapie von Ovarialtumoren bei Mongolischen Rennmäusen

Fischbach-Ulfik¹,

Meißner²,

Hungerkamp³

et al. 2022

kleintier konkret

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“…Ovarian neoplasms in Mongolian gerbils include, in addition to those mentioned above, papillary cystadenoma (15) and ovarian interstitial cell tumor (11). However, many (14).…”

Section: Introductionmentioning

confidence: 99%

Ovarian papillary carcinoma in a Mongolian gerbil (Meriones unguiculatus)

Claro,

Silva,

Maia

et al. 2023

BJVP

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Neoplasms are among the most impacting disease diagnoses in veterinary medicine and have become increasingly common due to the greater longevity of animals as living conditions improved. The Mongolian gerbil is a small rodent species that has become popular recently. In these animals, the occurrence of neoplastic processes is relatively common, mainly tumors of the ventral gland in males and ovarian tumors in females. This work aims to report an ovarian tumor in a Mongolian gerbil Meriones unguiculatus Milne-Edwards 1867 (Rodentia, Muridae). At the initial presentation, the animal had dyspnea, prostration, and increased abdominal volume in the topography of the right ovary of approximately 2 cm. The animal was submitted to exploratory laparotomy because of the emergency nature of the case and the owners’ refusal of additional exams due to financial restrictions. Thus, an ovariohysterectomy was performed, followed by a histopathological examination. The histopathology revealed an ovarian papillary carcinoma affecting both ovaries and cystic endometrial hyperplasia. With surgical removal and drainage of the thoracic fluid, the animal showed good recovery, with general improvement and return to regular activity, with a life expectancy of two years. Currently, the demand for specialized veterinarians for unconventional pets is increasing. This condition allows owners to raise their animals more properly, favoring greater longevity. Knowledge about the prevalence and incidence of diseases in different species is of enormous relevance in establishing the appropriate therapy, improving life quality, and increasing life expectancy in animals’ lives.

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“…Differently from the female rat prostate development, the periductal smooth muscle is continuous and the epithelium derives from 1 to 2 two prostatic buds during the intrauterine life, which go through branching and acini development during the second postnatal week (Sanches et al, 2016). They also demonstrate a spontaneous ability to easily develop neoplastic lesions, especially in the reproductive system (Campos et al, 2008; Kubiak et al, 2015; Quintar et al, 2017; Salyards et al, 2013). Thus, as an experimental model, gerbils mimic the natural environment of an individual susceptible to cancer (Custodio et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17‐β estradiol

Leonel

Ruiz

Bedolo

et al. 2021

Cell Biology International

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The mammary gland (MG) and female prostate are plastic reproductive organs which are highly responsive to hormones. Thus, endocrine disruptors, such as bisphenol A (BPA) and exogenous estrogens, negatively affect glandular homeostasis. In addition to previously described alterations, changes in inflammatory markers expression also trigger the development of a microenvironment that contributes to tumor progression. The current work aimed to evaluate the inflammatory responses of the MG and prostate gland to BPA (50 µg/kg) and 17‐β estradiol (35 µg/kg) exposure during the perinatal window of susceptibility. The results showed that at 6 months of age there was an increase in the number of phospho‐STAT3 (P‐STAT3) positive cells in the female prostate from animals perinatally exposed to 50 µg/kg BPA daily. In addition, the number of macrophages increased in these animals in comparison with nonexposed animals, as shown by the F4/80 marker. Despite an increase in the incidence of lobuloalveolar and intraductal hyperplasia, the MG did not show any difference in the expression of the four inflammatory markers evaluated: tumor necrosis factor‐α, COX‐2, P‐STAT3, and F4/80. Analysis of both glands from the same animal led to the conclusion that exposure to endocrine disruptors during the perinatal window of susceptibility leads to different inflammatory responses in different reproductive organs. As the prostate is more susceptible to these inflammatory mechanisms, it is reasonable to affirm that possible neoplastic alterations in this organ are related to changes in the inflammatory pattern of the stroma, a characteristic that is not evident in the MG.

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Ovarian interstitial cell tumour in a Mongolian gerbil (Meriones unguiculatus)

Cited by 5 publications

References 24 publications

Chirurgische Therapie von Ovarialtumoren bei Mongolischen Rennmäusen

Chirurgische Therapie von Ovarialtumoren bei Mongolischen Rennmäusen

Ovarian papillary carcinoma in a Mongolian gerbil (Meriones unguiculatus)

Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17‐β estradiol

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