Ovarian Malignancies With Cytologically Negative Pleural and Peritoneal Effusions: Demons’ or Meigs’ Pseudo-syndromes?

Peparini, Nadia; Chirletti, Piero

doi:10.1177/1066896909336441

Cited by 18 publications

(21 citation statements)

References 10 publications

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“…By definition, lack of evidence for peritoneal or pleural spread of the tumor must have been documented (negative pleural and peritoneal fluid cytology and/or no malignant involvement in biopsy samples) and both ascites and hydrothorax should have resolved after tumor removal. 15,23,24 …”

Section: Methodsmentioning

confidence: 99%

Pleural Effusion in Meigs’ Syndrome—Transudate or Exudate?

et al. 2015

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Although Meigs’ syndrome is regarded as a well-defined entity, contradictory data on pleural fluid characteristics have been presented, with some papers classifying it as a transudate, whereas others stating that it is an exudate.The aims of the study were: (1) to evaluate pleural fluid characteristics in patients with Meigs’ syndrome and (2) to analyze the prevalence of transudative and exudative pleural effusion in relation to the applied definition of the syndrome.We performed a search through medical databases (MEDLINE, EMBASE, SCOPUS, and GOOGLE SCHOLAR) to identify papers on Meigs’ syndrome published between 1940 and 2013. Two authors independently reviewed each paper searching for prespecified data: (1) signs and symptoms, (2) tumor characteristics, (3) clinical and laboratory data on ascites, (4) clinical, radiological, and laboratory data on pleural fluid, (5) clinical course after tumor removal. All case reports were reclassified according to a new unequivocal classification of Meigs’ syndrome-related entities.A total of 653 papers were initially identified, and 454 articles reporting 541 patients were included in the final analysis. After reclassification according to our case definitions, there were 196, 113, and 108 patients defined as classic Meigs’ syndrome, nonclassic Meigs’ syndrome, and pseudo-Meigs’ syndrome, respectively. Significantly more patients presented with right-sided than left-sided and bilateral pleural effusions (P < 0.001). Median volume of withdrawn pleural fluid was 2950 (1500–6000) mL. The classification of pleural effusion with the use of Light's criteria was possible in only 7 patients. In 6 of these patients pleural effusion met the criteria for an exudate. When the protein concentration > 3.0 g/dL was applied as a criterion of pleural exudate, 88.8% (80/90) of effusions were classified as exudates. Increasing the cut-off level to 3.5 g/dL resulted in only a modest decrease in the percentage of exudative effusions (81%, 73/90).Surprisingly few reports on Meigs’ syndrome present data reliably defining the character of pleural effusion. The available data indicate, however, that the majority of pleural effusions in patients with this entity are exudates. This finding may be a prerequisite for the verification of some earlier presented concepts.

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Section: Methodsmentioning

confidence: 99%

Pleural Effusion in Meigs’ Syndrome—Transudate or Exudate?

et al. 2015

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“…Other benign cysts of the ovary (such as struma ovarii, mucinous cystadenoma and teratomas), leiomyoma of the uterus, and secondary metastatic tumours to ovary if associated with hydro thorax are referred to as ‘Pseudo‐Meigs” syndrome 6 …”

Section: Introductionmentioning

confidence: 99%

Meigs' and Pseudo‐Meigs' syndrome

Saha

Robertson

2012

Australas J Ultrason Med

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“…Meigs' syndrome stands in contrast to pseudo-Meigs, which presents with ascites and pleural effusion in association with benign tumors of the ovary (other than fibromas) and malignant tumors. Benign tumors in this category include mucinous cystadenomas, teratomas, struma ovarii, and leiomyomas [3]. Although it is difficult to determine the incidence of Meigs' syndrome, it has been reported that 0.20 per 100,000 women are diagnosed with ovarian sex cord stromal tumors (SCST) [4].…”

Section: Introductionmentioning

confidence: 99%

Meigs’ Versus Pseudo-Meigs’ Syndrome: A Case of Pleural Effusion, Ascites, and Ovarian Mass

Nguyen¹,

Yazdanpanah²,

Schumaker³

2020

Cureus

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Meigs' syndrome is classically characterized as the triad of ascites, pleural effusion, and ovarian fibroma. The incidence is not easily determined but has been described in medical literature. We report a case of a patient who presented for shortness of breath and was found to have pleural effusion, ascites, and an ovarian mass. Investigative measures were consistent with Meigs' syndrome; however, definitive diagnosis was not able to be determined as our patient opted for symptomatic treatment rather than pursue surgical options. We discuss the pathophysiology of pleural effusion, ascites, and management of Meigs' and pseudo-Meigs' syndrome. Ultimately, we discuss palliative options for patients who are not ideal candidates for surgery.

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Ovarian Malignancies With Cytologically Negative Pleural and Peritoneal Effusions: Demons’ or Meigs’ Pseudo-syndromes?

Cited by 18 publications

References 10 publications

Pleural Effusion in Meigs’ Syndrome—Transudate or Exudate?

Pleural Effusion in Meigs’ Syndrome—Transudate or Exudate?

Meigs' and Pseudo‐Meigs' syndrome

Meigs’ Versus Pseudo-Meigs’ Syndrome: A Case of Pleural Effusion, Ascites, and Ovarian Mass

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