Ovarian Mature Cystic Teratoma Exhibiting Well-Differentiated Cerebellum in a 14-Year-Old Female

Michel, Joseph; Ortíz-Hidalgo, Carlos

doi:10.1007/s10024-004-7083-1

Cited by 7 publications

(3 citation statements)

References 2 publications

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“…Recent data support the hypothesis that medulloblasto- mas arise from the disturbance of pathways involved in external granule cell development. 6,10,11,14,15 Authors of other studies have reported finding mature cerebellar tissue within teratomas located outside the central nervous system axis, 4,17 which suggests that some of the progenitor cell and molecular cues necessary for cerebellar differentiation were available. It is possible that the process of cerebellar differentiation in our patient was disrupted by the genetic makeup of the underlying germ cell substrate, creating the conditions that gave rise instead to a medulloblastoma.…”

Section: Discussionmentioning

confidence: 99%

Medulloblastoma arising from an immature teratoma of the posterior fossa

Das¹,

Muro²,

Goldman

et al. 2007

Journal of Neurosurgery: Pediatrics

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Teratomas, a group of nongerminomatous germ cell tumors, account for 3% of all childhood tumors. These unusual lesions reproduce the cellular and structural phenotypic traits associated with the three classic germ layers in inappropriate places in the body and often retain an embryonal character. These immature cells can differentiate into more malignant neoplasms. An intracranial location for this lesion type is rare. The authors describe the case of a 2-year-old boy with a teratoma of the posterior fossa that had partially differentiated into a medulloblastoma.

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Section: Discussionmentioning

confidence: 99%

Medulloblastoma arising from an immature teratoma of the posterior fossa

Das¹,

Muro²,

Goldman

et al. 2007

Journal of Neurosurgery: Pediatrics

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“…Well‐differentiated and highly organized cerebellar or cerebral tissue has, albeit rarely, been reported in ovarian and extragonadal teratomas. In some cases the external granule cell layer was found on the surface of the molecular layer, and in one case fetal cerebellar tissue was found in association with a primitive neuroepithelial tumor resembling a medulloblastoma .…”

Section: Discussionmentioning

confidence: 99%

Well‐formed cerebellum and brainstem‐like structures in a mature ovarian teratoma: Neuropathological observations

et al. 2017

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In the surgical case of a mature cystic teratoma of the ovary that arose in a 16-year-old girl, a large amount of well-differentiated and highly organized cerebellar tissue was found. Three layers of the cerebellar cortex were well formed, and synaptophysin-positive "glomeruli" were found in the granule cell layer. Some Purkinje cells exhibited focal expansion and a dysmorphic appearance of the dendrites. Adjacent to the cerebellar tissue, a large space lined by the ependymal layer and a club-shaped CNS tissue mass resembling the brainstem were found, and structures reminiscent of the midbrain tectum and pontine nuclei were distinguished within this mass. The CNS tissue was surrounded by the leptomeninges and a skull-like, bony shell. Structures consistent with the supra-tentorial CNS tissue were not found. This case represents an example of infra-tentorial CNS tissue that was well-differentiated and organized to an exceptionally high degree in an ovarian mature teratoma. Various degenerative changes have been documented in CNS tissue in ovarian teratomas, but the dendritic abnormalities of Purkinje cells seen in the present case are novel findings.

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“…Although teratoma tissue elements are typically arranged in relatively haphazard manner, well-developed and organized embryonic organ structures that have been reported include mature bowel, bronchial tree, and male genitourinary components (2)(3)(4). Cases of well-formed neuroectodermal structures like brainstem and cerebellum have been reported, though such cases are extremely rare in the literature and usually with limited histologic, clinical, or gross characterization (5)(6)(7)(8). Each case exhibits unique appearances with variable levels of histologic organization, developmental stage, and dysmorphia.…”

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confidence: 99%

Well-developed Cerebellum in an Ovarian Mature Teratoma From a Pregnant Female

Sauer

Coy²,

Quade³

et al. 2021

International Journal of Gynecological Pathology

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Teratomas are the most common neoplasm of the ovary, comprising over half of all diagnosed tumors in patients under 50. Most lesions are classified as benign mature teratomas and are histologically defined by the presence of mature tissues from one or more of the embryological germ layers: ectoderm, mesoderm, and endoderm. Neuroectodermal derivatives, including glia, neurons, ependymal cells, and meninges are present in a third to half of mature teratomas. Although teratomatous tissue elements are typically arranged in a haphazard fashion, well-developed and organized embryonic organ structures have been rarely reported and often with limited histologic, clinical, or gross characterization. In this report, we describe the case of an ovarian mature cystic teratoma identified in a pregnant female which exhibited remarkably well-developed posterior fossa structures including lobated and foliated cerebellum with appropriate anatomic organization and associated brainstem, ventricular, and meningeal structures.

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Ovarian Mature Cystic Teratoma Exhibiting Well-Differentiated Cerebellum in a 14-Year-Old Female

Cited by 7 publications

References 2 publications

Medulloblastoma arising from an immature teratoma of the posterior fossa

Medulloblastoma arising from an immature teratoma of the posterior fossa

Well‐formed cerebellum and brainstem‐like structures in a mature ovarian teratoma: Neuropathological observations

Well-developed Cerebellum in an Ovarian Mature Teratoma From a Pregnant Female

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