Ovarian Metastasis from Lung Cancer: A Rare Entity

Abstract

This paper describes a case of ovarian metastasis from lung carcinoma along with its diagnostic challenges, clinical management, and review of the literature. A 49-year-old woman was admitted to our emergency department with complaints of abdominal pain and vomiting. A laparoscopic appendectomy was performed due to acute appendicitis, and a unilateral oophorectomy (left side) via laparoscopy was performed due to the detection of an ovarian mass. Immunohistochemical staining of the ovarian mass revealed that it was reactive to cytokeratin-7 (CK-7) but negative for CK-20. The immunohistochemical and pathological features of the tumor indicated an ovarian metastasis of non-small-cell lung cancer. The patient underwent chemotherapy and was followed up by the oncology department. Her postoperative regular followup of 6 months showed that her condition was stable with no recurrence. The management of female patients with acute abdominal pain and pelvic masses should consist of a multidisciplinary approach to include the diagnosis of any distant organ metastasis.

Ovary metastasis from lung cancer mimicking primary ovarian cancer: A rare case report

“…In contrast, primary lung tumors frequently appearing as solitary nodules which may appear solid, round or lobulated and have irregular and spiculated margins. However, imaging tests cannot confirm the differential diagnosis [ 10 , 21 ].…”

“…Patients often presented to the hospital with bowel obstruction due to ovarian metastases. At this point, surgery plays a role in resolving symptoms and making the diagnosis [ [21] , [22] , [23] ]. In our case, surgery not only helped to confirm the diagnosis of the disease but also to resolve abdominal pain symptoms and reduce the tumor burden.…”

Case report of 18F–fluorodeoxyglucose positron emission tomography‐computed tomography imaging of a patient with multiple endocrine gland metastases from small cell lung cancer

“…Ovarian malignant lesions are generally primary carcinomas and less frequently metastases from extra‐gynecological tumors . Ovarian metastasis from lung cancer represents only 2–4% of all ovarian metastatic lesions .…”

“…6 Ovarian metastasis from lung cancer represents only 2-4% of all ovarian metastatic lesions. 6 Because of completely different treatment methods and prognosis, distinguishing between a primary and metastatic ovarian neoplasm is critical to administer the correct therapeutic strategy. Primary ovarian neoplasms often present as large complex masses accompanied by increased CA125 levels and metastatic signs to the greater omentum and peritoneum.…”

“…Ovarian malignant lesions are generally primary carcinomas and less frequently metastases from extra‐gynecological tumors . Ovarian metastasis from lung cancer represents only 2–4% of all ovarian metastatic lesions . Because of completely different treatment methods and prognosis, distinguishing between a primary and metastatic ovarian neoplasm is critical to administer the correct therapeutic strategy.…”