Ovarian metastasis of renal cell carcinoma: Clinical and pathological presentation of a case

Abstract

A 82-year-old woman was referred to our hospital with complaints of weight loss, loss of appetite, abdominal pain and a palpable pelvic mass. Abdominal imaging revealed a tumour at the upper pole of the right kidney with a maximum diameter of 8 cm and a second tumour in the pelvis, mostly solid, with a maximum diameter of 16 cm, that seemed to originate from the left ovary. As she was initially considered to have two distinct tumours, through a single transabdominal incision, she simultaneously underwent right radical nephrectomy and also bilateral salpingo-oophorectomy for the tumour that originated from the left ovary. Histopathological examination showed that the tumour in the right kidney was a clear-cell renal cell carcinoma (RCC) (stage pT3a, Fuhrman grade 2). The ovarian tumour proved to be an ovarian fibroma that included a circumscribed focus with a diameter of 0.7 cm which was a metastasis from the kidney tumour. Immunohistochemistry contributed significantly to the diagnosis, as the focus showed strong and diffuse expression of CD10 and RCC antigen, which are reliable markers of RCC. With less than 30 reported cases in the literature, it is very important to differentiate ovarian metastasis of RCC from primary ovarian tumour due to different treatment alternatives and prognosis.

A population-based study to predict distant metastasis in patients with renal cell carcinoma

“…Our nomogram highlighted the fact that the rate of distant metastasis increased with the RCC differentiation (from well to poorly differentiated). Other reports similarly showed that poor pathological differentiation of RCC was correlated with inferior prognosis (45)(46)(47). This is not surprising, as the pathological differentiation grade reflects the tumor biological behavior and represents an independent predictor for distant RCC metastasis.…”

Bilateral ovarian metastasis of clear-cell renal cell carcinoma: A case report

“…However, a recent literature review of 41 cases by Koufopoulos et al [6] revealed nearly equal occurrence in the left (49%) versus right (51%) renal origins of ovarian metastasis. In the setting of bilateral ovarian masses and a renal mass, renal metastasis from a primary ovarian cancer can also be considered although this is considerably less common [14].…”

Scutellaria barbata: A Review on Chemical Constituents, Pharmacological Activities and Clinical Applications

“…Metastasis is the major cause of cancer-related deaths and targeting this process has been proposed as a strategy to fight cancer [45]. Dai et al investigated the antimetastatic effect of total flavonoids of S. barbata (TF-SB).…”