Ovarian mucinous tumors arising from mature cystic teratomas—a molecular genetic approach for understanding the cellular origin

Fujii, Kaho; Yamashita, Yoshihisa; Yamamoto, Toshimichi; Takahashi, Koji; Hashimoto, Kimiko; Miyata, Tomoko; Kawai, Kumi; Kikkawa, Fumitaka; Toyokuni, Shinya; Nagasaka, Tetsuro

doi:10.1016/j.humpath.2013.10.031

Cited by 41 publications

(38 citation statements)

References 34 publications

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“…Theories of some ovarian mucinous tumours arising from Walthards rests or Brenner tumours has also been entertained . Recently, a handful of molecular studies have provided evidence that a subset of ovarian mucinous tumours, including benign mucinous cystadenoma, borderline mucinous tumour and mucinous carcinoma, may arise from the coexisting teratoma . Using STR genotyping technology, Kerr et al .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, DNA genotyping through STR analysis can be used to assess the homozygosity of ovarian teratomas and coexisting mucinous tumours to determine the clonal relationship between the two. To date, there are only a handful of small series of genotyping studies of ovarian mucinous tumours with coexisting mature teratomas . Additional case studies are necessary to strengthen this theory.…”

Section: Introductionmentioning

confidence: 99%

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Mucinous epithelial tumours arising from ovarian mature teratomas: a tissue genotyping study

2016

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mucinous epithelial tumours arising from ovarian mature teratomas: a tissue genotyping study

2016

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“…Interestingly, recent studies on analysis of microsatellite polymorphism in mucinous ovarian carcinomas and associated teratomas showed a clonal match between the samples, suggesting that a subset of mucinous ovarian carcinoma actually arise from mature teratomas [27]. Fujii K et al also demonstrated that the origin of the intestinal-type mucinous tumors might arise from mature cystic teratomas by microdissection and analysis of microsatellite markers [28]. Related studies gave us a clue to isolate different teratoma components and explore molecular genetic analysis.…”

Section: Discussionmentioning

confidence: 99%

KRAS mutation in adenocarcinoma of the gastrointestinal type arising from a mature cystic teratoma of the ovary

Zhang

Pan

et al. 2014

J Ovarian Res

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Mature cystic teratomas (MCT) in the ovary rarely undergo malignant transformation. Moreover, adenocarcinoma of the gastrointestinal type is much rarer. We present two cases of perimenopausal female pateints with mature cystic teratoma of single ovary, while local adenocarcinoma arising in the MCT. The malignancies showed immunohistochemical features of intestinal differentiation, such as strong positivity for CDX-2, villin and CK-20, and negativity for CK-7. Furthermore, the mutation analysis of molecular alteration revealed a KRAS gene mutation in the intestinal adenocarcinoma part, extending into benign intestinal-type epithelium linings. Yet the mutation was not present in the epidermal component of the teratoma. We present these as two unique cases of mucinous adenocarcinoma of the intestinal type arising from mature cystic teratoma. Moreover, we also submit that this KRAS mutation might contribute to identify malignant transformation of a MCT and suggest possible effect on targeted treatment decisions for anti-epidermal growth factor receptor (EGFR) therapy in metastasized patients.

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“…96 The presence of rather scant clusters of bland epithelial cells in a background of mucin favors disseminated peritoneal adenomucinosis, while cellular fluids with numerous epithelial cell clusters demonstrating moderate to severe atypia typically correspond to peritoneal mucinous carcinomatosis (Fig. [101][102][103][104] Ovarian Seromucinous Neoplasms Ovarian seromucinous neoplasms contain two or more M€ ullerian cell types, including at least a serous and a mucinous component. 97 Metastatic mucinous neoplasms that may be encountered in the ovary include metastatic endocervical adenocarcinoma, colorectal adenocarcinoma, low-grade appendiceal mucinous neoplasms, and pancreatobiliary carcinoma.…”

Section: Ovarian Mucinous Neoplasmsmentioning

confidence: 99%

Abdominopelvic washings in gynecologic pathology: A comprehensive review

Schulte

Lastra

2016

Diagnostic Cytopathology

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Abdominopelvic washings (APW) performed during gynecologic surgeries have become a common specimen evaluated by cytopathologists. Their role in staging of female genital tract tumors has changed significantly since they were first described, and continue to evolve. The ability of these washings to detect microscopic disease, even in the absence of gross disease, warrants the critical role that these washings play in the staging of certain female gynecologic tract tumors, allowing for optimal staging and subsequent treatment of the patient. Irrespective of the underlying pathology, the gamut of cytomorphologic findings that may be observed in APW is extensive, and ranges from benign lesions that may act as mimickers of malignancy, to both common and rare malignancies. This review discusses the changing role of APW in the staging of gynecologic tumors, and highlights the salient cytomorphologic features of these lesions, with emphasis in their correct identification, including cautionary notes to avoid over or misinterpretation. Diagn. Cytopathol. 2016;44:1039-1057. © 2016 Wiley Periodicals, Inc.

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Ovarian mucinous tumors arising from mature cystic teratomas—a molecular genetic approach for understanding the cellular origin

Cited by 41 publications

References 34 publications

Mucinous epithelial tumours arising from ovarian mature teratomas: a tissue genotyping study

Mucinous epithelial tumours arising from ovarian mature teratomas: a tissue genotyping study

KRAS mutation in adenocarcinoma of the gastrointestinal type arising from a mature cystic teratoma of the ovary

Abdominopelvic washings in gynecologic pathology: A comprehensive review

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