Ovarian Pathology in Chronic Pelvic Inflammatory Disease

Bychkov, Vladimir

doi:10.1159/000293209

Cited by 5 publications

(5 citation statements)

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“…**P ≤ 0.05; *P ≤ 0.08 compared with untreated controls; analysis by nonparametric Mann-Whitney U test. ovarian follicle and that patients suffering PID show ovarian pathologies (Bychkov 1990, Pelzer et al 2011, Pelzer et al 2013. The data presented here suggest that GLCs can initiate an innate immune response to pathogen-associated molecules, potentially altering the microenvironment of the follicle.…”

Section: Discussionmentioning

confidence: 74%

“…Although PID is a cause of pelvic pain and infertility, little is known about the effects on the ovary and female gametes. However, it has been shown that patients with PID have reduced follicle numbers and increased cystic follicles and corpora lutea after the resolution of the initial infection (Weiner & Wallach 1974, Bychkov 1990. Retrospective analysis of patients undergoing fertility treatment suggest that increased endometrial LPS reduces IVF success (Kamiyama et al 2004).…”

Section: Introductionmentioning

confidence: 99%

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Human granulosa–luteal cells initiate an innate immune response to pathogen-associated molecules

et al. 2016

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The microenvironment of the ovarian follicle is key to the developmental success of the oocyte. Minor changes within the follicular microenvironment can significantly disrupt oocyte development, compromising the formation of competent embryos and reducing fertility. Previously described as a sterile environment, the ovarian follicle of women has been shown to contain colonizing bacterial strains, whereas in domestic species, pathogen-associated molecules are concentrated in the follicular fluid of animals with uterine infection. The aim of this study is to determine whether human granulosa-luteal cells mount an innate immune response to pathogenassociated molecules, potentially disrupting the microenvironment of the ovarian follicle. Human granulosa-luteal cells were collected from patients undergoing assisted reproduction. Cells were cultured in the presence of pathogen-associated molecules (LPS, FSL-1 and Pam3CSK4) for 24 h. Supernatants and total RNA were collected for assessment by PCR and ELISA. Granulosa-luteal cells were shown to express the molecular machinery required to respond to a range of pathogen-associated molecules. Expression of TLR4 varied up to 15-fold between individual patients. Granulosa-luteal cells increased the expression of the inflammatory mediators IL1B, IL6 and CXCL8 in the presence of the TLR4 agonist E. coli LPS. Similarly, the TLR2/6 ligand, FSL-1, increased the expression of IL6 and CXCL8. Although no detectable changes in CYP19A1 or STAR expression were observed in granulosa-luteal cells following challenge, a significant reduction in progesterone secretion was measured after treatment with FSL-1. These findings demonstrate the ability of human granulosa-luteal cells to respond to pathogen-associated molecules and generate an innate immune response.Reproduction (2016) 152 261-270

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Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Human granulosa–luteal cells initiate an innate immune response to pathogen-associated molecules

et al. 2016

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“…Pelvic inflammatory disease causes pain and infertility, and is the leading cause of gynecological hospitalization of women in the developed world (Ross, 2002). Studies in women suggest that PID causes ovarian changes similar to those seen in the dairy cow following uterine infection (Weiner and Wallach, 1974;Margolis, 1976;Bychkov, 1990). In addition, studies of infection and immunity using primary cells from the bovine uterus and ovary are similar to studies using human endometrial and ovarian cells (Sanchotello et al, 1992;Allhorn et al, 2008;Price et al, 2012).…”

Section: Animal Models Of Uterine Infection and Their Implicationsmentioning

confidence: 99%

PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Uterine infection: Linking infection and innate immunity with infertility in the high-producing dairy cow1,2

Bromfield

Santos

Block

et al. 2015

Journal of Animal Science

102

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Uterine contamination with bacteria is ubiquitous in the postpartum dairy cow. Nearly one-half of all postpartum dairy cows develop clinical disease resulting in metritis and endometritis, which cause depressed milk production and infertility. The causative links between uterine infection and infertility include a hostile uterine environment, disrupted endocrine signaling, and perturbations in ovarian function and oocyte development. In this review we consider the various mechanisms linking uterine infection with infertility in the dairy cow, specifically 1) innate immune signaling in the endometrium, 2) alteration in endocrine signaling in response to infectious agents, and 3) impacts of infection on ovarian function, oocyte development, and follicular development. Normal ovarian follicular and oocyte development requires a series of temporally and spatially orchestrated events; however, several of the cellular pathways required for ovarian function are also used during the innate immune response to bacterial pathogens. We propose that activation of cellular pathways during this immune response has a negative impact on ovarian physiology, which is manifest as infertility detected after the clearance of the bacteria. This review highlights how new insights into infection and immunity in cattle are linked to infertility.

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“…Its clinical features vary according to the patient's immune and health status. Typically, there are no obvious symptoms and signs of PID until chronic inflammation develops in the pelvic cavity, which can lead to serious consequences, such as preterm labor [2], infertility [3], ectopic pregnancy [4], and pelvic Open Access *Correspondence: akamarucoh1116@gmail.com; d0562@mail.cmuh.org.tw 1 Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan Full list of author information is available at the end of the article organ adhesions [5]. Research has shown that infection and chronic inflammation play an important role in carcinogenesis [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Association of pelvic inflammatory disease (PID) with ovarian cancer: a nationwide population-based retrospective cohort study from Taiwan

et al. 2021

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Background Pelvic inflammatory disease (PID) is an important health issue for women. Infection and inflammation play an important role in carcinogenesis and PID has been reported to be associated with ovarian cancer in some small scale studies. Aim We sought to determine whether PID is associated with an elevated risk of ovarian cancer in Asian women. Methods Using data from Taiwan’s National Health Insurance Research Database (NHIRD), our retrospective cohort study included women diagnosed with PID (cases) between the years of 2000 till 2012. Each case was matched with two women without PID (controls) by age and the year of first entry into the database. Both study cohorts were followed-up until the first event of ovarian cancer, withdrawal from the NHI program, death, or the end of the study period (December 31, 2012). Cox proportional hazards regression models were used to estimate crude and adjusted hazard ratios (HRs and aHRs) with their corresponding 95% confidence intervals (95% CIs) for the association of PID and ovarian cancer risk, with and without adjusting for potential confounders. Results During an approximate 10 years of follow-up, cases were significantly more likely than controls to develop ovarian cancer (incidence rates of 0.27 and 0.16 per 1,000 person-years, respectively; P < 0.001). Women with a history of PID had a 1.49-fold elevated risk for ovarian cancer (aHR, 1.49; 95% CI, 1.21–1.84; P < 0.001). Conclusion Our study evidence supports the contention that PID increases the risk of developing ovarian cancer among Taiwanese women. Gynecologists should undertake careful assessments and closely follow patients with PID, who are at long-term risk of developing ovarian cancer. Our findings need further verification in other international cohorts.

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Ovarian Pathology in Chronic Pelvic Inflammatory Disease

Cited by 5 publications

References 3 publications

Human granulosa–luteal cells initiate an innate immune response to pathogen-associated molecules

Human granulosa–luteal cells initiate an innate immune response to pathogen-associated molecules

PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Uterine infection: Linking infection and innate immunity with infertility in the high-producing dairy cow1,2

Association of pelvic inflammatory disease (PID) with ovarian cancer: a nationwide population-based retrospective cohort study from Taiwan

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