Ovarian reserve evaluation: state of the art

Carvalho, Bruno Ramalho de; Silva, Ana Carolina Japur de Sá Rosa e; Silva, Júlio César Rosa e; Reis, Rosana Maria dos; Ferriani, Rui Alberto; Sá, Marcos Felipe Silva de

doi:10.1007/s10815-008-9241-2

Cited by 52 publications

(44 citation statements)

References 93 publications

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“…Serum and ultrasonographic markers have been tested to infer the gonadal reserve of infertile women, but none has been proven to reflect the complex follicular dynamics or be strongly correlated with the size and/or quality of the primordial follicles remaining in the gonads. Thus, these tests do not ideally reflect the pool of unrecruited follicles, which may be responsible for ovulatory cycles and the long-term reproductive potential [25][26][27][28]. Age, menstrual cycle length, basal serum FSH, basal estradiol, clomiphene citrate challenge test, AFC, ovarian volume, and ovarian blood flow had been reported to evaluate ovarian reserve, but we need more markers to make the cycle cheaper and more likely to be successful [29][30][31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Basal serum testosterone levels correlate with ovarian response but do not predict pregnancy outcome in non-PCOS women undergoing IVF

Sun

Wang

Sun

et al. 2014

J Assist Reprod Genet

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Purpose To evaluate basal testosterone (T) levels in women undergoing in vitro fertilization (IVF) cycles and examine the association between basal T levels and ovarian response or IVF pregnancy outcome. Methods We retrospectively analyzed 1413 infertile Chinese women undergoing their first IVF treatment at our institution's reproductive center from March 2011 to May 2013. The basal testosterone (T) levels in women undergoing in vitro fertilization (IVF) and the relationship between basal T levels and ovarian response or IVF pregnancy outcome were determined. These patients did not have polycystic ovary syndrome (PCOS) or endometriosis, and were treated with a long luteal down-regulation protocol. Subjects were divided into 2 groups according to basal testosterone (T) levels: Group 1, basal T values <20 ng/dl (n=473), and Group 2, basal T values >20 ng/dl (n=940). We evaluated the association of basal T levels with ovarian response and IVF outcome in the two groups. Results In this study, BMI, basal follicle-stimulating hormone (FSH) levels, basal luteinizing hormone (LH) levels, antral follicle count (AFC), days of stimulation, total gonadotrophin dose, basal FSH/LH ratio, and the number of follicles >14 mm were significantly different (P<0.05) between the two groups. Basal T level positively correlated with ovarian reserve function, number of follicles >14 mm on human chorionic gonadotrophin (HCG) day, and total gonadotropin dose. However, basal T levels play no role in predicting IVF pregnancy outcome. Conclusion Basal T level can be used as a good predictor for ovarian response and the number of large follicles on HCG day. Additionally, we may use basal T level as a marker to predict FSH dosage. In general women, lower level of T might relate with potential poor ovarian response. However, based on our data, basal T levels do not predict pregnancy outcome.

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Section: Discussionmentioning

confidence: 99%

Basal serum testosterone levels correlate with ovarian response but do not predict pregnancy outcome in non-PCOS women undergoing IVF

Sun

Wang

Sun

et al. 2014

J Assist Reprod Genet

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“…The ideal marker would show a significant change in levels from adolescence to the late reproductive period and should enable age-independent prediction of an individual's reproductive life span and spontaneous pregnancy in the general population. Ovarian reserve tests include a variety of biochemical and ultrasound parameters (1)(2)(3)(4). Currently available ultrasound tests of ovarian reserve include antral follicular count (AFC), ovarian volume, and Doppler assessment of ovarian blood flow (5)(6)(7)(8)(9).…”

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Age-specific nomogram for the decline in antral follicle count throughout the reproductive period

Marca

Spada

Sighinolfi

et al. 2011

Fertility and Sterility

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“…Elle pourrait constituer un marqueur plus précoce de l'appauvrissement ovarien [37]. Cependant, la technique de dosage de cette hormone reste actuellement difficile à maîtriser et empêche donc une définition précise des normes ;…”

Section: éValuation De La Réserve Ovarienneunclassified

Management of infertility in ejaculatory disorders: joint opinion of the andrologist, the biologist and the gynecologist

Marcelli

Leroy

Robin

et al. 2009

Basic Clin. Androl.

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Résumé Quatre-vingts pour cent des hommes qui présentent des troubles de l’éjaculation sont en âge de procréer, mais seul 5 à 10 % en sont spontanément capables. Du sperme antérograde et/ou rétrograde peut être recueilli par éjaculation assistée en association à des traitements pharmacologiques (chlorhydrate de minodrine-vibroéjaculation). En cas d’échecs de recueil de sperme et d’azoospermie, l’extraction chirurgicale des spermatozoïdes épididymaires ou testiculaires permet d’obtenir des spermatozoïdes, en quantité généralement moins importante que les techniques d’éjaculation assistée, mais non infectés et dépourvus de plasma séminal (souvent délétère dans les troubles de l’éjaculation). Même en cas d’éjaculation antérograde, il est impératif de recueillir les urines systématiquement à la recherche d’une éjaculation rétrograde, fréquente dans les troubles de l’éjaculation. Au laboratoire, l’analyse du sperme et de l’urine s’effectue par les méthodes de routine standardisées. La plupart des hommes présentant des troubles de l’éjaculation ont un sperme de mauvaise qualité (asthénospermie, nécrospermie, leucospermie). Les étiologies de la dégradation des paramètres du sperme sont multifactorielles, d’origine centrale et périphérique (testiculaire et extratesticulaire). Optimiser la qualité du sperme et des spermatozoïdes reste un challenge d’actualité dans les troubles de l’éjaculation. Si la cryopréservation doit être systématique, l’utilisation du sperme frais optimisé a généralement la préférence. Réussir à obtenir du sperme offre au couple une chance de grossesse naturelle (rarement) grâce à une éjaculation coïtale, par auto-insémination, par insémination intra-utérine, par fécondation in vitro conventionnelle (FIVc) ou injection intracytoplasmique de spermatozoïdes (ICSI) dans l’ovocyte. Dans les troubles de l’éjaculation, la prise en charge de la fécondité de l’homme doit être la plus rapide possible. Elle s’effectue conjointement à celle de la femme par une équipe coordonnant l’andrologue, le biologiste et le gynécologue.

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Ovarian reserve evaluation: state of the art

Cited by 52 publications

References 93 publications

Basal serum testosterone levels correlate with ovarian response but do not predict pregnancy outcome in non-PCOS women undergoing IVF

Basal serum testosterone levels correlate with ovarian response but do not predict pregnancy outcome in non-PCOS women undergoing IVF

Age-specific nomogram for the decline in antral follicle count throughout the reproductive period

Management of infertility in ejaculatory disorders: joint opinion of the andrologist, the biologist and the gynecologist

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