Ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas

Дубинина, В. Г.; Носенко, О. М.; Chuzhyk, Olena; S., Grytsenko, G.

doi:10.15574/hw.2016.112.165

Cited by 2 publications

(5 citation statements)

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“…The assessment of risk factors determining OR in women of the examined groups made it possible to establish probable reasons for its decrease. Taking into account the data of literary sources published in recent years regarding the sharp reduction of the pool of primordial follicles after 36 years (up to 25,000) [3,5,6], we also established a greater proportion of older patients with OEC in group I (33.8±2.9 years compared to 30.2±3.7 years in group II, respectively). According to generally accepted statistics, women aged 20-30 are able to perform their reproductive function, but by the age of 40, only 50% of fertility reserves are preserved, and after 43, even in the absence of menopause, the physiological limitations of OR lead to its loss [3,5,6].…”

Section: Figure 2 Peculiarities Of Clinical Symptoms Of Pid In Patien...mentioning

confidence: 64%

“…Discussion. More and more scientific researchers prove the negative impact of OEC on the functional state of the ovaries and the quality of oocytes; they confirm their point of view in domestic and foreign research works [1][2][3][4][5]. Their conclusions are based on echographic, histological, as well as biochemical criteria: a decrease in the number of follicles in women with OEC, a greater number of atretic follicles, changes in the intrafollicular environment and granulosa cells, an increase in the level of intracellular free radicals, etc.…”

Section: Figure 2 Peculiarities Of Clinical Symptoms Of Pid In Patien...mentioning

confidence: 81%

“…[17,18]. The authors demonstrate that the change in the status of oxidative stress partially explains the decrease in the number of follicles and oocytes developing in IVF cycles in women with bilateral endometriomas, the decrease in the rate of spontaneous ovulation in the ovaries containing OEC [5,8,11]. At present, according to the results of the studied literary sources, it should be noted that endometriomas lead to damage of the surrounding tissues of the ovary, regardless of the size of the cyst [15,18].…”

Section: Figure 2 Peculiarities Of Clinical Symptoms Of Pid In Patien...mentioning

confidence: 99%

“…Of special interest is the question of the genesis of infertility, first of all, a decrease in the ovarian reserve, which can be caused by the spectrum of a number of pathophysiological processes caused by endometrioma in the ovarian tissue, and are confirmed by a decrease in serum anti-Mullerian hormone, the number of antral follicles, a decrease in the response to controlled stimulation of the ovaries and the need for more high doses of gonadotropins used in programs of assisted reproductive technologies [5,6,8,15].…”

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confidence: 99%

“…The causes of infertility in women with endometriosis are multifactorial, as the cysts themselves, and a decrease in the ovarian reserve after surgery can become the initiator in the mechanisms of infertility. The existing possibilities of surgical and medical treatment of endometriosis help to get pregnant only in 15-25% of cases, and after surgical treatment the chances of getting a spontaneous pregnancy are reduced by 4% annually [5,6,8,11,15]. Ambiguous and debatable scientific statements regarding the negative impact of endometrioma on OR remain relevant and not fully structured.…”

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confidence: 99%

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Assessment of ovarian reserve and role of its determining factors in patients with endometriomas combined with pelvic inflammatory disease

Bihun

Henyk

2022

J Educ Health Sport

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Resume. Endometriosis affects from 10% to 50% of women of reproductive age and is one of the most common diseases in gynecology. One of its most common kinds – ovarian endometrial cysts – accounts from 17% to 44% of all patients. The aim of the study was to evaluate the parameters of the ovarian reserve in patients with endometriomas combined with pelvic inflammatory disease. Research materials and methods. Two groups of patients were formed: group I included 45 women with endometriomas combined with pelvic inflammatory disease; group II consisted of 45 patients with isolated endometriomas. Generally accepted criteria were used to assess the ovarian reserve: FSH level, AMH > 1.0 n/ml, number of follicles D, volume of both ovaries. Statistical calculations included the method of calculating the odds ratio (OR) and its 95% confidental interval (95% CI). Research results and their discussion. The frequency of the decrease in main parameters of the ovarian reserve showed a deviation in two-thirds of cases in women of group I (68.9%), which is 2.2 times more common (p<0.05). AMH parameters showed a deviation by 3.6 times compared to the control group, and by 1.7 times compared to the parameters of group II (p<0.05). The average level of FSH in blood serum of women in group I was 2.0 times higher than the control indicators, and 1.5 times higher than the indicators of patients in group II. The number of antral follicles < 5 in group II was in 22.2% of observations; and in group 1 – in 91.1% (p<0.05). The endometrioma itself demonstrated a significant influence on the parameters of the ovarian reserve: in the case of a significant share of multiple bilateral endometrial cysts (OR=5.65; 95% CI: (1.71-18.67); p<0.05), their large sizes (OR=7.94; 95% CI: (3.0-21.0); p<0.05), combination with pelvic inflammatory disease, (OR=29.42; 95% CI: (6.33 -146.72); p<0.05) and tubo-ovarian tumours (OR=6.96; 95% CI: (1.44-33.51); p<0.05), as well as aggressive consequences during surgical intervention on both ovaries (OR=8.26; 95% CI: (2.65-25.79); p<0.05). Conclusions. About half of the patients with endometriomas combined with pelvic inflammatory disease note a decrease in the ovarian reserve. Statistically reliable factors are multiple and large ovarian endometrial cysts, a combination with recurrent pelvic inflammatory disease, tubo-ovarian tumours and surgical interventions on the ovaries.

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Section: Figure 2 Peculiarities Of Clinical Symptoms Of Pid In Patien...mentioning

confidence: 64%

Section: Figure 2 Peculiarities Of Clinical Symptoms Of Pid In Patien...mentioning

confidence: 81%

Section: Figure 2 Peculiarities Of Clinical Symptoms Of Pid In Patien...mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Assessment of ovarian reserve and role of its determining factors in patients with endometriomas combined with pelvic inflammatory disease

Bihun

Henyk

2022

J Educ Health Sport

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Ovarian Reserve Condition in Women with Menstrual Dysfunction in the Puberty

Kovalishin

2020

FMEP

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The concept of «ovarian reserve» in recent years has been widely discussed in the literature. This is a functional reserve of the ovaries, reflecting the size of the follicular pool of the ovaries and the quality of the oocytes in them, that is, it characterizes the ability of the ovaries to develop a healthy follicle with a full egg. Determination of ovarian reserve allows you to more accurately assess the reproductive potential of women and prevent pathological conditions and diseases that reduce fertility.The objective: аccording to laboratory and instrumental methods of research, to give a comprehensive assessment of the condition of the ovarian reserve in women with menstrual dysfunction in the puberty.Materials and methods. The main group of women (n=90) with a pathology of menstrual function in the puberty, according to the nature of the violations, was divided into 3 subgroups (n=30): the first – women with primary oligomenorrhea in the anamnesis, the second – with late age menarche, the third – with puberty bleeding. The control group consisted of women (n=30) with the correct rhythm of menstruation in puberty. The age range of the subjects is from 19 to 32 years. The biochemical and echographic markers of the ovarian reserve were studied.Results. In a clinical study, it was found that in women with menstrual dysfunction in the puberty, the concentration of antimuller hormone (AMH) in the blood serum and the size of the ovaries (total volume) are greater due to the greater number of small follicles compared to women in the control group. A direct correlation between the parameters of AMH and the number of follicles and the inverse between AMH and the diameter of the follicles indicate normal ovarian reserve. This pattern was observed in women with a primary history of oligomenorrhea and late menarche. In women with pubertal hemorrhages, the concentration of AMH in the blood did not significantly differ from the control group, the total volume of both ovaries was greater than in women with a normal rhythm of menstruation (p<0,05), but the total number of follicles did not differ significantly. The correlation between the total volume of both ovaries and the total number of follicles was lost, which may indicate an increase in ovarian volume due to the stromal component.Conclusion. A comprehensive analysis of the level of AMH in serum, the total volume of the ovaries and the number of follicles in the preovulatory period allows us to estimate the ovulatory reserve in women with menstrual dysfunction in the pubertal period. And although the indicated parameters in the examined women are significantly higher than in women with the correct rhythm of menstruation (p<0,05), they remain within the reference values, which indicates the preservation of their ovarian reserve. Today, for screening the ovarian reserve, determining the concentration of AMH in the blood serum has several significant advantages over other methods, because this hormone is a marker that begins to change with age before other indicators, which is of great prognostic value in the treatment of various disorders of the reproductive system, premature extinction its function and infertility.

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Ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas

Cited by 2 publications

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Assessment of ovarian reserve and role of its determining factors in patients with endometriomas combined with pelvic inflammatory disease

Assessment of ovarian reserve and role of its determining factors in patients with endometriomas combined with pelvic inflammatory disease

Ovarian Reserve Condition in Women with Menstrual Dysfunction in the Puberty

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