Ovarian reserve in women with primary antiphospholipid syndrome

Yamakami, Lucas Yugo Shiguehara; Serafini, P.; Araújo, Daniel Brito de; Bonfá, Eloísa; Leon, Elaine Pires; Baracat, Edmund C.; Silva, C A

doi:10.1177/0961203314529468

Cited by 38 publications

(33 citation statements)

References 30 publications

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“…Both methods may be used in the ovarian reserve assessment [24]. The comparable results obtained herein and in accordance to other studies in autoimmune rheumatic diseases with high positive correlation between the two AMH assays [6,23,25,26] minimized the instability in terms of AMH Gen II ELISA values reported previously [27].…”

Section: Discussionsupporting

confidence: 93%

Reduced ovarian reserve in patients with adult polymyositis

et al. 2015

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Polymyositis (PM) affects female gender during reproductive age; however, there is no study assessing ovarian reserve in these patients to evaluate ovarian reserve markers in PM. Eight female patients with PM (Bohan and Peter criteria, 1975) with aged 18-40 years, followed at our tertiary centre from March 2011 to May 2014, were invited to participate. They were age-matched with 16 healthy individuals (control group). All were evaluated at early follicular phase of menstrual cycle. Follicle stimulating hormone (FSH), estradiol, inhibin B, anti-Müllerian hormone (AMH) serum levels (ELISA) and sonographic antral follicle count (AFC) were determined. PM patients and controls had comparable mean age (31.4 ± 6.5 vs. 30.7 ± 6.2 years, P = 0.946), ethnicity and socioeconomic class (P > 0.05). PM mean age of onset was 27.3 ± 6.5 years and disease duration of 6.5 ± 4.1 years. Menstrual cycles were alike in both groups with a similar frequency of age at menarche, gynaecological age, duration and length of menstrual cycle (P > 0.05). The median serum level of AMH was significantly lower in PM compared to controls [0.7(0.3-3.4) vs. 3.1(1.4-4.0), P = 0.021]. AMH levels ≤1 ng/mL (50 vs. 6.3 %, P = 0.024) and very low AFC (37.5 vs. 6.3 %, P = 0.037) were significantly in PM patients versus controls. The other hormones (FSH, inhibin B and estradiol levels) were similar between both groups (P > 0.05). The present study was the first to identify subclinical ovarian dysfunction in PM patients during reproductive ages. Further study is necessary to assess the possible role of PM-related factors that may influence the ovarian function of these patients.

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Section: Discussionsupporting

confidence: 93%

Reduced ovarian reserve in patients with adult polymyositis

et al. 2015

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“…In previous studies, it was reported that AMH levels were more sensitive in indicating ovarian reserves, and, as the number of follicles decreased with increasing age, AMH levels also decreased [ 4 ]. In recent years, AMH has again been identified as a helper marker in the follow-up of ovarian reserves in women with rheumatic diseases [ 5 – 7 ]. However, we did not come across any study in the literature evaluating ovarian reserves in female FMF patients with AMH levels.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Ovarian Reserve with Anti-Müllerian Hormone in Familial Mediterranean Fever

Şahin

Karakuş

Durmaz

et al. 2015

International Journal of Rheumatology

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Objective. To investigate ovarian reserves in attack-free familial Mediterranean fever (AF-FMF) patients at the reproductive age by anti-Müllerian hormone (AMH), antral follicle count (AFC), ovarian volume, and hormonal parameters. Methods. Thirty-three AF-FMF patients aging 18–45 years and 34 healthy women were enrolled and FSH, LH, E2, PRL, and AMH levels were measured in the morning blood samples at 2nd–4th days of menstruation by ELISA. Concomitant pelvic ultrasonography was performed to calculate AFC and ovarian volumes. Results. In FMF patient group, median AMH levels were statistically significantly lower in the M69V mutation positive group than in the negative ones (P = 0.018). There was no statistically significant difference in median AMH levels between E148Q mutation positive patients and the negative ones (P = 0.920). There was also no statistically significant difference in median AMH levels between M680I mutation positive patients and the negative ones (P = 0.868). No statistically significant difference was observed in median AMH levels between patients who had at least one mutation and those with no mutations (P = 0.868). We realized that there was no difference in comparisons between ovarian volumes, number of follicles, and AMH levels ovarian reserves when compared with FMF patients and healthy individuals. Conclusions. Ovarian reserves of FMF pateints were similar to those of healthy subjects according to AMH. However, AMH levels were lower in FMF patients with M694V mutation.

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“…The confirmation of this association in future studies, therefore, could lead to the early diagnosis of this condition in many women. 29,31 Antiphospholipid antibody syndrome and obstetrics morbidity…”

Section: Antiphospholipid Antibody Syndrome and Primary Infertilitymentioning

confidence: 99%

Antiphospholipid Antibody Syndrome and Infertility

Rodrigues

Soligo

Pannain

2019

Rev Bras Ginecol Obstet

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Antiphospholipid antibody syndrome (APS) is a systemic, autoimmune, prothrombotic disease characterized by persistent antiphospholipid antibodies (aPLs), thrombosis, recurrent abortion, complications during pregnancy, and occasionally thrombocytopenia. The objective of the present study was to review the pathophysiology of APS and its association with female infertility. A bibliographic review of articles of the past 20 years was performed at the PubMed, Scielo, and Bireme databases. Antiphospholipid antibody syndrome may be associated with primary infertility, interfering with endometrial decidualization and with decreased ovarian reserve. Antiphospholipid antibodies also have direct negative effects on placentation, when they bind to the trophoblast, reducing their capacity for invasion, and proinflammatory effects, such as complement activation and neutrophil recruitment, contributing to placental insufficiency, restricted intrauterine growth, and fetal loss. In relation to thrombosis, APS results in a diffuse thrombotic diathesis, with global and diffuse dysregulation of the homeostatic balance. Knowing the pathophysiology of APS, which is closely linked to female infertility, is essential for new therapeutic approaches, specialized in immunomodulation and inflammatory signaling pathways, to provide important advances in its treatment.

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Ovarian reserve in women with primary antiphospholipid syndrome

Abstract: Women suffering from PAPS possessed reduced ovarian reserve, with prevalence greater than 50%.

Cited by 38 publications

References 30 publications

Reduced ovarian reserve in patients with adult polymyositis

Reduced ovarian reserve in patients with adult polymyositis

Evaluation of Ovarian Reserve with Anti-Müllerian Hormone in Familial Mediterranean Fever

Antiphospholipid Antibody Syndrome and Infertility

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